| Description | multiple isoforms; BH3 only protein (the BH3 domain is essential for proapoptotic function). |
| Expression | wide |
| Localisation | mitochondria |
| Function | BBC3 is transcriptionally induced upon diverse apoptotic stimuli to induce apoptosis via the mitochondrial apoptotic pathway. BBC3 is transcriptionally activated by p53; it is also upregulated after endoplasmic reticulum stress, independantly to P53 status. BBC3 is also transactvated by p73, a p53 related protein with, also, G1 cell cycle arrest and apoptosis functions. BBC3 induces BAX conformational change and multimerization. |
| Homology | Bcl2 family members:
The antiapoptotic members with BH 1 to 4 domains: BCL2 (18q21), (20q11), (14q11), BCL1L10/BCL-B/BOO/DIVA (15q21), BCL2A1/BFL1/A1 (15q24), BNIP1/EIB-19K (5q33), MCL1 (1q21) The proapoptotic members with BH 1 to 3 domains: BAK1/BCL2L7 (6p21), BAX (19q13), (22q11), (2q37) The only-BH3 apoptotic members: BAD/BCL2L8/BBC2 (11q13), BCL2L11/BIM/BOD (2q13), BID (22q11), BIK/NBK/BBC1 (22q13), BLK (8p23), BMF (15q14), BNIP3/NIP3 (10q26), BMIP3L/NIX (8p21), HRK/DP5/BID3 (12q24), PMAIP1/NOXA (18q21) |
| Control of proliferation by Bcl-2 family members. |
| Bonnefoy-Berard N, Aouacheria A, Verschelde C, Quemeneur L, Marçais A, Marvel J |
| Biochimica et biophysica acta. 2004 ; 1644 (2-3) : 159-168. |
| PMID 14996500 |
| |
| Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. |
| Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, Zhu L, Chittenden T |
| Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (20) : 11318-11323. |
| PMID 11572983 |
| |
| Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia. |
| Liu FT, Newland AC, Jia L |
| Biochemical and biophysical research communications. 2003 ; 310 (3) : 956-962. |
| PMID 14550297 |
| |
| p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. |
| Melino G, Bernassola F, Ranalli M, Yee K, Zong WX, Corazzari M, Knight RA, Green DR, Thompson C, Vousden KH |
| The Journal of biological chemistry. 2004 ; 279 (9) : 8076-8083. |
| PMID 14634023 |
| |
| PUMA, a novel proapoptotic gene, is induced by p53. |
| Nakano K, Vousden KH |
| Molecular cell. 2001 ; 7 (3) : 683-694. |
| PMID 11463392 |
| |
| Structural biology of the Bcl-2 family of proteins. |
| Petros AM, Olejniczak ET, Fesik SW |
| Biochimica et biophysica acta. 2004 ; 1644 (2-3) : 83-94. |
| PMID 14996493 |
| |
| Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. |
| Reimertz C, Kögel D, Rami A, Chittenden T, Prehn JH |
| The Journal of cell biology. 2003 ; 162 (4) : 587-597. |
| PMID 12913114 |
| |
| Bcl-2 family members: integrators of survival and death signals in physiology and pathology [corrected]. |
| Schinzel A, Kaufmann T, Borner C |
| Biochimica et biophysica acta. 2004 ; 1644 (2-3) : 95-105. |
| PMID 14996494 |
| |
| Bcl-2 family members and disease. |
| Sorenson CM |
| Biochimica et biophysica acta. 2004 ; 1644 (2-3) : 169-177. |
| PMID 14996501 |
| |
| The voltage-dependent anion channel: an essential player in apoptosis. |
| Tsujimoto Y, Shimizu S |
| Biochimie. 2002 ; 84 (2-3) : 187-193. |
| PMID 12022949 |
| |
| PUMA mediates the apoptotic response to p53 in colorectal cancer cells. |
| Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L |
| Proceedings of the National Academy of Sciences of the United States of America. 2003 ; 100 (4) : 1931-1936. |
| PMID 12574499 |
| |
| PUMA induces the rapid apoptosis of colorectal cancer cells. |
| Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B |
| Molecular cell. 2001 ; 7 (3) : 673-682. |
| PMID 11463391 |
| |
