Atlas of Genetics and Cytogenetics in Oncology and Haematology
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
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BBC3 (BCL2 binding component 3)
| Identity |
| Other names | PUMA (p53-upregulated modulator of apoptosis) |
| JFY1 | |
| HGNC (Hugo) | BBC3 |
| LocusID (NCBI) | 27113 |
| Location | 19q13.32 |
| Location_base_pair | Starts at 47724079 and ends at 47736023 bp from pter ( according to hg19-Feb_2009) [Mapping] |
| DNA/RNA |
| Description | The gene spans 12kb on the reverse strand; 8 exons |
| Transcription | numerous transcripts |
| Protein |
| Description | multiple isoforms; BH3 only protein (the BH3 domain is essential for proapoptotic function). |
| Expression | wide |
| Localisation | mitochondria |
| Function | BBC3 is transcriptionally induced upon diverse apoptotic stimuli to induce apoptosis via the mitochondrial apoptotic pathway. BBC3 is transcriptionally activated by p53; it is also upregulated after endoplasmic reticulum stress, independantly to P53 status. BBC3 is also transactvated by p73, a p53 related protein with, also, G1 cell cycle arrest and apoptosis functions. BBC3 induces BAX conformational change and multimerization. |
| Homology | Bcl2 family members: |
| Implicated in |
| Note | BBC3 mediates apoptosis in various cancer cells. |
| External links |
| Bibliography |
| PUMA, a novel proapoptotic gene, is induced by p53. |
| Nakano K, Vousden KH |
| Molecular cell. 2001 ; 7 (3) : 683-694. |
| PMID 11463392 |
| PUMA induces the rapid apoptosis of colorectal cancer cells. |
| Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B |
| Molecular cell. 2001 ; 7 (3) : 673-682. |
| PMID 11463391 |
| Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. |
| Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, Zhu L, Chittenden T |
| Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (20) : 11318-11323. |
| PMID 11572983 |
| The voltage-dependent anion channel: an essential player in apoptosis. |
| Tsujimoto Y, Shimizu S |
| Biochimie. 2002 ; 84 (2-3) : 187-193. |
| PMID 12022949 |
| PUMA mediates the apoptotic response to p53 in colorectal cancer cells. |
| Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L |
| Proceedings of the National Academy of Sciences of the United States of America. 2003 ; 100 (4) : 1931-1936. |
| PMID 12574499 |
| Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia. |
| Liu FT, Newland AC, Jia L |
| Biochemical and biophysical research communications. 2003 ; 310 (3) : 956-962. |
| PMID 14550297 |
| Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. |
| Reimertz C, Kgel D, Rami A, Chittenden T, Prehn JH |
| The Journal of cell biology. 2003 ; 162 (4) : 587-597. |
| PMID 12913114 |
| p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. |
| Melino G, Bernassola F, Ranalli M, Yee K, Zong WX, Corazzari M, Knight RA, Green DR, Thompson C, Vousden KH |
| The Journal of biological chemistry. 2004 ; 279 (9) : 8076-8083. |
| PMID 14634023 |
| Structural biology of the Bcl-2 family of proteins. |
| Petros AM, Olejniczak ET, Fesik SW |
| Biochimica et biophysica acta. 2004 ; 1644 (2-3) : 83-94. |
| PMID 14996493 |
| Bcl-2 family members: integrators of survival and death signals in physiology and pathology [corrected]. |
| Schinzel A, Kaufmann T, Borner C |
| Biochimica et biophysica acta. 2004 ; 1644 (2-3) : 95-105. |
| PMID 14996494 |
| Control of proliferation by Bcl-2 family members. |
| Bonnefoy-Berard N, Aouacheria A, Verschelde C, Quemeneur L, Marais A, Marvel J |
| Biochimica et biophysica acta. 2004 ; 1644 (2-3) : 159-168. |
| PMID 14996500 |
| Bcl-2 family members and disease. |
| Sorenson CM |
| Biochimica et biophysica acta. 2004 ; 1644 (2-3) : 169-177. |
| PMID 14996501 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 08-2004 | Jean-Loup Huret, Sylvie Senon |
| Citation |
| This paper should be referenced as such : |
| Huret, JL ; Senon, S |
| BBC3 (BCL2 binding component 3) |
| Atlas Genet Cytogenet Oncol Haematol. 2004;8(4):278-279. |
| Free journal version : [ pdf ] [ DOI ] |
| URL : http://AtlasGeneticsOncology.org/Genes/BBC3ID759ch19q13.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Tue Feb 17 20:30:40 CET 2015 |
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