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BBC3 (BCL2 binding component 3)

Identity

Other namesPUMA (p53-upregulated modulator of apoptosis)
JFY1
HGNC (Hugo) BBC3
LocusID (NCBI) 27113
Location 19q13.32
Location_base_pair Starts at 47724079 and ends at 47736023 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Description The gene spans 12kb on the reverse strand; 8 exons
Transcription numerous transcripts

Protein

Description multiple isoforms; BH3 only protein (the BH3 domain is essential for proapoptotic function).
Expression wide
Localisation mitochondria
Function BBC3 is transcriptionally induced upon diverse apoptotic stimuli to induce apoptosis via the mitochondrial apoptotic pathway. BBC3 is transcriptionally activated by p53; it is also upregulated after endoplasmic reticulum stress, independantly to P53 status. BBC3 is also transactvated by p73, a p53 related protein with, also, G1 cell cycle arrest and apoptosis functions. BBC3 induces BAX conformational change and multimerization.
Homology Bcl2 family members:
  • The antiapoptotic members with BH 1 to 4 domains: BCL2 (18q21), BCL1L1/BCLX-L ID: n129> (20q11), BCL2L2/BCL-W (14q11), BCL1L10/BCL-B/BOO/DIVA (15q21), BCL2A1/BFL1/A1 (15q24), BNIP1/EIB-19K (5q33), MCL1 (1q21) HOMOLOGY
  • The proapoptotic members with BH 1 to 3 domains: BAK1/BCL2L7 (6p21), BAX (19q13), (22q11), (2q37)
  • The only-BH3 apoptotic members: BAD/BCL2L8/BBC2 (11q13), BCL2L11/BIM/BOD (2q13), BID (22q11), BIK/NBK/BBC1 (22q13), BLK (8p23), BMF (15q14), BNIP3/NIP3 (10q26), BMIP3L/NIX (8p21), HRK/DP5/BID3 (12q24), PMAIP1/NOXA (18q21)

    • Implicated in

    Note BBC3 mediates apoptosis in various cancer cells.
      

    External links

    Nomenclature
    HGNC (Hugo)BBC3   17868
    Entrez_Gene (NCBI)BBC3  27113  BCL2 binding component 3
    Cards
    AtlasBBC3ID759ch19q13
    GeneCards (Weizmann)BBC3
    Ensembl (Hinxton)ENSG00000105327 [Gene_View]  chr19:47724079-47736023 [Contig_View]  BBC3 [Vega]
    AceView (NCBI)BBC3
    Genatlas (Paris)BBC3
    SOURCE (Stanford)NM_001127240 NM_001127241 NM_001127242 NM_014417
    Genomic and cartography
    GoldenPath (UCSC)BBC3  -  19q13.32   chr19:47724079-47736023 -  19q13.3-q13.4   [Description]    (hg19-Feb_2009)
    EnsemblBBC3 - 19q13.3-q13.4 [CytoView]
    Mapping of homologs : NCBIBBC3 [Mapview]
    OMIM605854   
    Gene and transcription
    Genbank (Entrez)AA887822 AF332558 AF354654 AF354655 AF354656
    RefSeq transcript (SRS)NM_001127240 NM_001127241 NM_001127242 NM_014417
    RefSeq transcript (Entrez)NM_001127240 NM_001127241 NM_001127242 NM_014417
    RefSeq genomic (SRS)AC_000151 NC_000019 NC_018930 NG_031991 NT_011109 NW_001838496 NW_004078099
    RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_031991 NT_011109 NW_001838496 NW_004078099
    Consensus coding sequences : CCDS (NCBI)BBC3
    Cluster EST : UnigeneHs.467020 [ SRS ] Hs.467020 [ NCBI ]
    CGAP (NCI)Hs.467020
    Alternative Splicing : Fast-db (Paris)GSHG0015949
    Alternative Splicing GalleryENSG00000105327
    Gene ExpressionBBC3 [ NCBI-GEO ]   BBC3 [ EBI - ARRAY_EXPRESS ]
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtQ9BXH1 (SRS) Q9BXH1 (Uniprot)
    NextProtQ9BXH1
    With graphics : InterProQ9BXH1
    Splice isoforms : SwissVarQ9BXH1(Swissvar)
    Domaine pattern : Prosite (SRS)BH3 (PS01259)   
    Domaine pattern : Prosite (Expaxy)BH3 (PS01259)   
    Related proteins : CluSTrQ9BXH1
    Domain families : Pfam (SRS)
    Domain families : Pfam (Sanger)
    Domain families : Pfam (NCBI)
    DMDM27113
    Blocks (Seattle)Q9BXH1
    Human Protein AtlasENSG00000105327
    HPRD16165
    IPIIPI00186516   IPI00004338   IPI00895857   IPI00044436   IPI00982382   
    Protein Interaction databases
    DIP (DOE-UCLA)Q9BXH1
    IntAct (EBI)Q9BXH1
    FunCoupENSG00000105327
    REACTOMEBBC3
    Protein Interaction Database27113
    BioGRIDBBC3
    InParanoidQ9BXH1
    Interologous Interaction database Q9BXH1
    IntegromeDBBBC3
    Polymorphism : SNP, mutations, diseases
    SNP Single Nucleotide Polymorphism (NCBI)BBC3
    SNP (GeneSNP Utah)BBC3
    SNP : HGBaseBBC3
    Genetic variants : HAPMAPBBC3
    Somatic Mutations in Cancer : COSMICBBC3 
    CONAN: Copy Number AnalysisBBC3 
    Mutations and Diseases : HGMDBBC3
    OMIM605854   
    GENETests605854   
    Disease Genetic AssociationBBC3
    Huge Navigator BBC3 [HugePedia]  BBC3 [HugeCancerGEM]
    Genomic VariantsBBC3  BBC3 [DGVbeta]
    snp3D : Map Gene to Disease27113
    General knowledge
    Homologs : HomoloGeneBBC3
    Homology/Alignments : Family Browser (UCSC)BBC3
    Phylogenetic Trees/Animal Genes : TreeFamBBC3
    Chemical/Protein Interactions : CTD27113
    Chemical/Pharm GKB GenePA38471
    Clinical trialBBC3
    Cancer Resource (Charite)ENSG00000105327
    Ontology : AmiGOrelease of cytochrome c from mitochondria  protein binding  mitochondrion  mitochondrion  mitochondrial outer membrane  cytosol  apoptotic process  apoptotic process  apoptotic process  induction of apoptosis  activation of cysteine-type endopeptidase activity involved in apoptotic process  determination of adult lifespan  positive regulation of protein homooligomerization  reduction of endoplasmic reticulum calcium ion concentration  response to endoplasmic reticulum stress  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  positive regulation of neuron apoptotic process  negative regulation of growth  release of sequestered calcium ion into cytosol  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  positive regulation of thymocyte apoptotic process  cellular response to hypoxia  positive regulation of release of cytochrome c from mitochondria  positive regulation of release of cytochrome c from mitochondria  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  positive regulation of cysteine-type endopeptidase activity  positive regulation of intrinsic apoptotic signaling pathway  
    Ontology : EGO-EBIrelease of cytochrome c from mitochondria  protein binding  mitochondrion  mitochondrion  mitochondrial outer membrane  cytosol  apoptotic process  apoptotic process  apoptotic process  induction of apoptosis  activation of cysteine-type endopeptidase activity involved in apoptotic process  determination of adult lifespan  positive regulation of protein homooligomerization  reduction of endoplasmic reticulum calcium ion concentration  response to endoplasmic reticulum stress  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  positive regulation of neuron apoptotic process  negative regulation of growth  release of sequestered calcium ion into cytosol  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  positive regulation of thymocyte apoptotic process  cellular response to hypoxia  positive regulation of release of cytochrome c from mitochondria  positive regulation of release of cytochrome c from mitochondria  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  positive regulation of cysteine-type endopeptidase activity  positive regulation of intrinsic apoptotic signaling pathway  
    Other databases
    Probes
    Litterature
    PubMed105 Pubmed reference(s) in Entrez
    PubGeneBBC3
    iHOPBBC3

    Bibliography

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    Molecular cell. 2001 ; 7 (3) : 683-694.
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    PUMA induces the rapid apoptosis of colorectal cancer cells.
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    PMID 11463391
     
    Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals.
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    Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (20) : 11318-11323.
    PMID 11572983
     
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    PMID 12022949
     
    PUMA mediates the apoptotic response to p53 in colorectal cancer cells.
    Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L
    Proceedings of the National Academy of Sciences of the United States of America. 2003 ; 100 (4) : 1931-1936.
    PMID 12574499
     
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    PMID 14550297
     
    Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway.
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    PMID 12913114
     
    p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation.
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    Bcl-2 family members: integrators of survival and death signals in physiology and pathology [corrected].
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    Biochimica et biophysica acta. 2004 ; 1644 (2-3) : 95-105.
    PMID 14996494
     
    Control of proliferation by Bcl-2 family members.
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    PMID 14996501
     
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

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    Contributor(s)

    Written08-2004Jean-Loup Huret, Sylvie Senon

    Citation

    This paper should be referenced as such :
    Huret JL, Senon S . BBC3 (BCL2 binding component 3). Atlas Genet Cytogenet Oncol Haematol. August 2004 .
    URL : http://AtlasGeneticsOncology.org/Genes/BBC3ID759ch19q13.html

    This paper is referenced by INIST as such :
    http://documents.irevues.inist.fr/bitstream/2042/38120/1/08-2004-BBC3ID759ch19q13.pdf   [ Bibliographic record ]

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    indexed on : Wed May 1 13:04:41 CEST 2013
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