Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis. |
Bennett HL, Brummer T, Jeanes A, Yap AS, Daly RJ. |
Oncogene. 2008 Apr 24;27(19):2693-704. Epub 2007 Nov 12. |
PMID 17998934 |
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A role for the scaffolding adapter GAB2 in breast cancer. |
Bentires-Alj M, Gil SG, Chan R, Wang ZC, Wang Y, Imanaka N, Harris LN, Richardson A, Neel BG, Gu H. |
Nat Med. 2006 Jan;12(1):114-21. Epub 2005 Dec 20. |
PMID 16369543 |
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Genome-wide association studies in Alzheimer's disease. |
Bertram L, Tanzi RE. |
Hum Mol Genet. 2009 Oct 15;18(R2):R137-45. (REVIEW) |
PMID 19808789 |
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Focal amplification and oncogene dependency of GAB2 in breast cancer. |
Bocanegra M, Bergamaschi A, Kim YH, Miller MA, Rajput AB, Kao J, Langerod A, Han W, Noh DY, Jeffrey SS, Huntsman DG, Borresen-Dale AL, Pollack JR. |
Oncogene. 2010 Feb 4;29(5):774-9. Epub 2009 Nov 2. |
PMID 19881546 |
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Amplification of 11q13 in ovarian carcinoma. |
Brown LA, Kalloger SE, Miller MA, Shih IeM, McKinney SE, Santos JL, Swenerton K, Spellman PT, Gray J, Gilks CB, Huntsman DG. |
Genes Chromosomes Cancer. 2008 Jun;47(6):481-9. |
PMID 18314909 |
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Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. |
Brummer T, Larance M, Herrera Abreu MT, Lyons RJ, Timpson P, Emmerich CH, Fleuren ED, Lehrbach GM, Schramek D, Guilhaus M, James DE, Daly RJ. |
EMBO J. 2008 Sep 3;27(17):2305-16. |
PMID 19172738 |
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Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. |
Brummer T, Schramek D, Hayes VM, Bennett HL, Caldon CE, Musgrove EA, Daly RJ. |
J Biol Chem. 2006 Jan 6;281(1):626-37. Epub 2005 Oct 27. |
PMID 16253990 |
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THOC5 couples M-CSF receptor signaling to transcription factor expression. |
Carney L, Pierce A, Rijnen M, Gonzalez Sanchez MB, Hamzah HG, Zhang L, Tamura T, Whetton AD. |
Cell Signal. 2009 Feb;21(2):309-16. Epub 2008 Nov 5. |
PMID 19015024 |
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Association study of the GAB2 gene with the risk of developing Alzheimer's disease. |
Chapuis J, Hannequin D, Pasquier F, Bentham P, Brice A, Leber I, Frebourg T, Deleuze JF, Cousin E, Thaker U, Amouyel P, Mann D, Lendon C, Campion D, Lambert JC. |
Neurobiol Dis. 2008 Apr;30(1):103-6. Epub 2008 Jan 5. |
PMID 18272374 |
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Transcriptional regulation of AKT activation by E2F. |
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Mol Cell. 2004 Dec 3;16(5):831-7. |
PMID 15574337 |
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GAB2 amplifications refine molecular classification of melanoma. |
Chernoff KA, Bordone L, Horst B, Simon K, Twadell W, Lee K, Cohen JA, Wang S, Silvers DN, Brunner G, Celebi JT. |
Clin Cancer Res. 2009 Jul 1;15(13):4288-91. Epub 2009 Jun 9. |
PMID 19509136 |
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The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer. |
Daly RJ, Gu H, Parmar J, Malaney S, Lyons RJ, Kairouz R, Head DR, Henshall SM, Neel BG, Sutherland RL. |
Oncogene. 2002 Aug 1;21(33):5175-81. |
PMID 12140767 |
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Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2. |
Dorsey JF, Cunnick JM, Mane SM, Wu J. |
Blood. 2002 Feb 15;99(4):1388-97. |
PMID 11830491 |
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Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development. |
Fleuren ED, O'Toole S, Millar EK, McNeil C, Lopez-Knowles E, Boulghourjian A, Croucher DR, Schramek D, Brummer T, Penninger JM, Sutherland RL, Daly RJ. |
Int J Cancer. 2010 Jan 19. [Epub ahead of print] |
PMID 20087860 |
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Gab2 requires membrane targeting and the Met binding motif to promote lamellipodia, cell scatter, and epithelial morphogenesis downstream from the Met receptor. |
Frigault MM, Naujokas MA, Park M. |
J Cell Physiol. 2008 Mar;214(3):694-705. |
PMID 17894413 |
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Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. |
Gu H, Pratt JC, Burakoff SJ, Neel BG. |
Mol Cell. 1998 Dec;2(6):729-40. |
PMID 9885561 |
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Essential role for Gab2 in the allergic response. |
Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG. |
Nature. 2001 Jul 12;412(6843):186-90. |
PMID 11449275 |
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Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. |
Harkiolaki M, Tsirka T, Lewitzky M, Simister PC, Joshi D, Bird LE, Jones EY, O'Reilly N, Feller SM. |
Structure. 2009 Jun 10;17(6):809-22. |
PMID 19523899 |
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Gab2-mediated signaling promotes melanoma metastasis. |
Horst B, Gruvberger-Saal SK, Hopkins BD, Bordone L, Yang Y, Chernoff KA, Uzoma I, Schwipper V, Liebau J, Nowak NJ, Brunner G, Owens D, Rimm DL, Parsons R, Celebi JT. |
Am J Pathol. 2009 Apr;174(4):1524-33. |
PMID 19342374 |
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The GAB2 gene and the risk of Alzheimer's disease: replication and meta-analysis. |
Ikram MA, Liu F, Oostra BA, Hofman A, van Duijn CM, Breteler MM. |
Biol Psychiatry. 2009 Jun 1;65(11):995-9. Epub 2008 Dec 31. |
PMID 19118819 |
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Role of Gab2 in mammary tumorigenesis and metastasis. |
Ke Y, Wu D, Princen F, Nguyen T, Pang Y, Lesperance J, Muller WJ, Oshima RG, Feng GS. |
Oncogene. 2007 Jul 26;26(34):4951-60. Epub 2007 Feb 19. |
PMID 17310989 |
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The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo. |
Kim HJ, Zhang K, Zhang L, Ross FP, Teitelbaum SL, Faccio R. |
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2325-30. Epub 2009 Jan 26. |
PMID 19171907 |
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Increased expression of Gab2, a scaffolding adaptor of the tyrosine kinase signalling, in gastric carcinomas. |
Lee SH, Jeong EG, Nam SW, Lee JY, Yoo NJ, Lee SH. |
Pathology. 2007 Jun;39(3):326-9. |
PMID 17558859 |
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GAB2 is not associated with late-onset Alzheimer's disease in Chinese Han. |
Lin K, Tang M, Han H, Guo Y, Lin Y, Ma C. |
Neurol Sci. 2009 Nov 19. [Epub ahead of print] |
PMID 19924507 |
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PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. |
Lynch DK, Daly RJ. |
EMBO J. 2002 Jan 15;21(1-2):72-82. |
PMID 11782427 |
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PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. |
Mao D, Epple H, Uthgenannt B, Novack DV, Faccio R. |
J Clin Invest. 2006 Nov;116(11):2869-79. Epub 2006 Oct 19. |
PMID 17053833 |
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Grb2 associated binder 2 couples B-cell receptor to cell survival. |
Maus M, Medgyesi D, Kovesdi D, Csuka D, Koncz G, Sarmay G. |
Cell Signal. 2009 Feb;21(2):220-7. Epub 2008 Oct 12. |
PMID 18950707 |
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A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase. |
Million RP, Harakawa N, Roumiantsev S, Varticovski L, Van Etten RA. |
Mol Cell Biol. 2004 Jun;24(11):4685-95. |
PMID 15143164 |
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The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer. |
Mira A, Isella C, Renzulli T, Cantarella D, Martelli ML, Medico E. |
Oncogene. 2009 Dec 17;28(50):4444-55. Epub 2009 Oct 19. |
PMID 19838208 |
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GAB2 is not associated with late-onset Alzheimer's disease in Japanese. |
Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R. |
Eur J Hum Genet. 2009 May;17(5):682-6. Epub 2008 Oct 15. |
PMID 18854865 |
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Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. |
Mohi MG, Williams IR, Dearolf CR, Chan G, Kutok JL, Cohen S, Morgan K, Boulton C, Shigematsu H, Keilhack H, Akashi K, Gilliland DG, Neel BG. |
Cancer Cell. 2005 Feb;7(2):179-91. |
PMID 15710330 |
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Implication of GAB2 gene polymorphism in Italian patients with Alzheimer's disease. |
Nacmias B, Tedde A, Bagnoli S, Cellini E, Guarnieri BM, Piacentini S, Sorbi S. |
J Alzheimers Dis. 2009 Mar;16(3):513-5. |
PMID 19276544 |
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Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling. |
Nakaoka Y, Nishida K, Narimatsu M, Kamiya A, Minami T, Sawa H, Okawa K, Fujio Y, Koyama T, Maeda M, Sone M, Yamasaki S, Arai Y, Koh GY, Kodama T, Hirota H, Otsu K, Hirano T, Mochizuki N. |
J Clin Invest. 2007 Jul;117(7):1771-81. |
PMID 17571162 |
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Requirement of Gab2 for mast cell development and KitL/c-Kit signaling. |
Nishida K, Wang L, Morii E, Park SJ, Narimatsu M, Itoh S, Yamasaki S, Fujishima M, Ishihara K, Hibi M, Kitamura Y, Hirano T. |
Blood. 2002 Mar 1;99(5):1866-9. |
PMID 11861309 |
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The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit. |
Pedersen M, Ronnstrand L, Sun J. |
Cell Signal. 2009 Mar;21(3):413-8. Epub 2008 Nov 17. |
PMID 19049823 |
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GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. |
Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA. |
Neuron. 2007 Jun 7;54(5):713-20. |
PMID 17553421 |
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Critical role for Gab2 in transformation by BCR/ABL. |
Sattler M, Mohi MG, Pride YB, Quinnan LR, Malouf NA, Podar K, Gesbert F, Iwasaki H, Li S, Van Etten RA, Gu H, Griffin JD, Neel BG. |
Cancer Cell. 2002 Jun;1(5):479-92. |
PMID 12124177 |
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Enhanced sensitivity to inhibition of SHP2, STAT5, and Gab2 expression in chronic myeloid leukemia (CML). |
Scherr M, Chaturvedi A, Battmer K, Dallmann I, Schultheis B, Ganser A, Eder M. |
Blood. 2006 Apr 15;107(8):3279-87. Epub 2005 Nov 8. |
PMID 16278304 |
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GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results. |
Schjeide BM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, Blacker D, Tanzi RE, Bertram L. |
Arch Neurol. 2009 Feb;66(2):250-4. |
PMID 19204163 |
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Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia. |
Sleegers K, Bettens K, Brouwers N, Engelborghs S, van Miegroet H, De Deyn PP, Van Broeckhoven C. |
Hum Mutat. 2009 Feb;30(2):E338-44. |
PMID 18853460 |
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BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor. |
Tao WJ, Lin H, Sun T, Samanta AK, Arlinghaus R. |
Oncogene. 2008 May 15;27(22):3194-200. Epub 2007 Dec 10. |
PMID 18071309 |
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The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. |
Wada T, Nakashima T, Oliveira-dos-Santos AJ, Gasser J, Hara H, Schett G, Penninger JM. |
Nat Med. 2005 Apr;11(4):394-9. Epub 2005 Mar 6. |
PMID 15750601 |
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Function, regulation and pathological roles of the Gab/DOS docking proteins. |
Wohrle FU, Daly RJ, Brummer T. |
Cell Commun Signal. 2009a Sep 8;7:22. |
PMID 19737390 |
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Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. |
Wu J, Meng F, Lu H, Kong L, Bornmann W, Peng Z, Talpaz M, Donato NJ. |
Blood. 2008 Apr 1;111(7):3821-9. Epub 2008 Jan 30. |
PMID 18235045 |
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Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression. |
Yuan Y, Qin L, Liu D, Wu RC, Mussi P, Zhou S, Songyang Z, Xu J. |
Cancer Res. 2007 Sep 1;67(17):8032-42. |
PMID 17804714 |
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GAB2 is a novel target of 11q amplification in AML/MDS. |
Zatkova A, Schoch C, Speleman F, Poppe B, Mannhalter C, Fonatsch C, Wimmer K. |
Genes Chromosomes Cancer. 2006 Sep;45(9):798-807. |
PMID 16736498 |
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Abnormal hematopoiesis in Gab2 mutant mice. |
Zhang Y, Diaz-Flores E, Li G, Wang Z, Kang Z, Haviernikova E, Rowe S, Qu CK, Tse W, Shannon KM, Bunting KD. |
Blood. 2007 Jul 1;110(1):116-24. Epub 2007 Mar 20. |
PMID 17374739 |
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