| Entity | MESENCHYMAL BENIGN TUMORS as follows: |
| | |
| Entity | Lipoma |
| Disease | benign adipocyte tumor |
| Prognosis | good |
| Cytogenetics | various rearrangements involving 12q15 (translocations, inversions, deletions...); reciprocal translocations involve 12q15 with different partners such as chromosomes 1, 2, 3, 7, 10, 11, 13, 15, 17, 21, X; the most frequent anomaly is t(3;12)(q27-28;q15); cryptic rearrangements, such as paracentric inversions not detectable by conventional cytogenetics but detectable by FISH, have been described |
| Hybrid/Mutated Gene | for t(3;12): HMGIC-LPP (LPP: lipoma preferred partner; 3q27-28); a gene located in 13q, LHFP (lipoma HMGIC fusion partner) was found to be fused with HMGIC in one case of lipoma; one lipoma displayed fusion of HMGA2 exon 4 with a sequence from intron 4, indicating abnormal splicing; HMGA2-CMKOR1 in three cases with aberrations involving 2q35-37 and 12q13-15; HMGA2-NFIB in one lipoma; |
| Abnormal Protein | HMGIC-LPP; the three AT hook domains at the aminoterminal of HMGIC are fused to the LIM domain of LPP; another fusion protein due to the fusion of HMGIC with a putative gene located at 15q24 predicted to encode a protein with a serine/threonine-rich domain has also been described |
| Oncogenesis | the relevance of the exact role LPP in the HMGA2-LPP fusion is not established yet, but the transactivation functions of the LPP LIM domains is retained in the fusion protein and the fusion protein can function as a transcription factor; the truncation of HMGA2 by itself may have a role in the tumorigenesis |
| | |
| Entity | Uterine leiomyoma (uterine fibroids) |
| Disease | benign mesenchymal tumors |
| Prognosis | good |
| Cytogenetics | approximately 40% of uterine leiomyomas have structural chromosomal rearrangements, about 10% of which involve 12q15 (translocations, inversions, deletions...); the most frequent anomaly is t(12;14)(q15;q23-24) |
| |  |
| |
| Hybrid/Mutated Gene | in a majority of cases, there is no fusion gene: the breakpoint is located 10 kb up to 100 kb 5' to HMGIC; the recombinational repair gene RAD51B is a candidate to be the partner gene of HMGIC in t(12;14). In two cases (out of 81 primary tumors) exon 7 of RAD51B was fused in frame to either exon 2 or 3 of the HMGA2 gene; in one case with paracentric inversion, HMGIC exon 3 was fused to ALDH2 exon 13 (12q24.1); in one case (no cytogenetic analysis) HMGIC exon 3 was fused to COX6C 3' UTR (8q22-23); in one case, with apparently normal karyotype, exon 3 of HMGIC was fused to retrotransposon-like sequences RTVLH 3' LTRs; three fusion transcripts contained 3' cryptic exonic sequences present in intron 3 of the HMGA2 gene (breakpoints downstream of exons 3 or 4), suggesting that they are due to alternative splicing; one case displayed fusion of the first two exons of HMGA2 to the 3' portion of the CCNB1IP1/C14orf18/HEI10 gene |
| Abnormal Protein | HMGIC-ALDH2: ALDH2 contribution was only 10 amino acids; |
| Oncogenesis | HMGIC-ALDH2: it is suggested that the truncation of HMGIC, rather than fusion may be responsible for tumorigenesis; the 3' untranslated region may stabilize the HMGIC messenger RNA |
| | |
| Entity | Pleomorphic adenoma of the salivary gland (or mixed salivary gland tumor) |
| Disease | benign tumors from the major or minor salivary glands |
| Prognosis | good |
| Cytogenetics | approximately 12% of pleomorphic adenomas of salivary glands show abnormalities involving HMGIC in 12q15; the most frequent aberration is t(9;12)(p24.1;q15) |
| Hybrid/Mutated Gene | in t(9;12): HMGIC-NFIB fusion; another type of fusion HMGIC-FHIT (3p14.2) has also been described |
| | |
| Entity | Pulmonary chondroid hamartoma of the lung |
| Disease | benign mesenchymal tumors of the lung |
| Prognosis | good |
| Cytogenetics | various rearrangements involving 12q15 leading to HMGIC dysregulation; cryptic rearrangements such as paracentric inversions not detectable by conventional cytogenetics but detectable by FISH have been described |
| Hybrid/Mutated Gene | in two cases with apparently normal karyotypes, exon 3 of HMGIC was fused to retrotransposon-like sequences RTVLH 3' LTRs; in cases with t(3;12)(q27-28;q14-15) (see lipomas), a fusion of HMGA2-LPP was described; only 1/61 cases with normal karyotype displayed HMGA2-LPP fusion; three cases with rearrangements involving 12q14-15 and 13q12-14 lacked rearrangements of HMGA2-LHFP; |
| |  |
| |
| | |
| Entity | Endometrial polyps |
| Disease | uterine benign tumors |
| Prognosis | good |
| Cytogenetics | various rearrangements involving 12q15 leading to HMGIC dysregulation; cryptic rearrangements such as paracentric inversions not detectable by conventional cytogenetics but detectable by FISH have been described; in one case, HMGIC was amplified and overexpressed |
| | |
| Entity | Myofibroblastic inflammatory tumor |
| Disease | benign mesenchymal tumors |
| Prognosis | good |
| Cytogenetics | in one case, a complex rearrangement involving chromosomes 12 (in 12q15), 4 and 21 was described |
| Hybrid/Mutated Gene | an aberrant transcript was produced by the fusion of HMGIC exon 3 to an ectopic sequence originating from the third intron of HMGIC |
| | |
| Entity | Chondrolipoangioma |
| Disease | a rare benign type of mesenchyomas composed predominantly of cartilage and adipose tissue with vascular elements and myxoid elements |
| Cytogenetics | One case demonstrated t(12;15)(q13;q26). FISH analysis revealed rearrangement of chromosomes 2, 12 and 15 and HMGA2. |
| | |
| Entity | Chondromas |
| Disease | benign cartilage tumours |
| Cytogenetics | HMGA2 was expressed in 4/6 soft tissue chondromas (all with 12q-rearrangements cytogenetically), three cases showed truncated (exons 1-3) transcripts, one case displayed a t(3;12)(q27;q15) and RT-PCR demonstrated a HMGA2-LPP fusion transcript composed of HMGA2 exons 1-3 and LPP exons 9-11. |
| | |
| Entity | Hyaline vascular Castleman's disease |
| Cytogenetics | one case with der(6)t(6;12)(q23;q15)del(12)(q15) is described. |
| Hybrid/Mutated Gene | a combined immunologic-cytogenetic approach demonstrated HMGA2 rearrangement in follicular dendritic cells |
| | |
| Entity | Prolactinoma |
| Disease | prolactin-secreting pituary adenoma, non-metastasizing |
| Cytogenetics | trisomy 12 nonrandom finding in pituary adenomas |
| Hybrid/Mutated Gene | HMGA2 locus amplified in 7/8 prolactinomas |
| | |
| Entity | Aggressive angiomyxoma of the vulva |
| Disease | myxoid mesenchymal neoplasm |
| Prognosis | infiltrative neoplasm, locally destructive recurrences, no metastatic potential |
| Cytogenetics | one case displayed t(8;12)(p12;q15) |
| Hybrid/Mutated Gene | FISH demonstrated a breakpoint 3' of the gene, the tumour expressed HMGA2 |
| | |
| Entity | MALIGNANT TUMORS as follows: |
| | |
| Entity | Well-differentiated liposarcoma |
| Disease | malignant adipocyte tumor; peripheral or retroperitoneal location |
| Prognosis | rather good; borderline malignancy; locally aggressive, rarely metastasizes |
| Cytogenetics | supernumerary ring or giant marker chromosomes containing 12q14-15 amplification (surrounding MDM2); HMGIC is frequently amplified together with MDM2; rearrangement of HMGA2, in addition to amplification has been described |
| Hybrid/Mutated Gene | ectopic sequences from 12q14-15, 1q24, 11q14, and chromosome 2 was shown to be fused to HMGA2 exon 2 or 3 |
| | |
| Entity | Uterine leiomyosarcoma |
| Disease | malignant counterpart of uterine leiomyoma |
| Prognosis | poor |
| Cytogenetics | 12q13-15 region is recurrently amplified |
| Hybrid/Mutated Gene | HMGA2 amplified within this region |
| | |
| Entity | Osteosarcoma |
| Disease | malignant tumor |
| Hybrid/Mutated Gene | in one osteosarcoma cell line (OsA-Cl) the three DNA binding domains of HMGIC fused to the keratan sulfate protein glycan gene LUM (12q22-23); LUM was fused out of frame, and only 3 amino acids were fused to HMGIC; in addition, the rearranged gene was amplified |
| | |
| Entity | with myeloid metaplasia |
| Disease | rare chronic myeloproliferative disorder |
| Prognosis | variable |
| Cytogenetics | one case with t(4;12)(q32;q15) and one case with t(5;12)(p14;q15) |
| Hybrid/Mutated Gene | FISH analysis suggested breakpoint in HMGA2, RT-PCR revealed that HMGA2 is expressed in blood mononuclear cells from patients with this disease |
| | |
| Entity | Acute lymphoblastic leukaemia |
| Disease | Heterogenous disease that arises in precursor B or T cells |
| Cytogenetics | One case with a t(9;12)(p22;q14), frequent deletions at 12q14.3 |
| Hybrid/Mutated Gene | t(9;12): FISH analysis indicated a breakpoint in the 5' region of the gene, RT-PCR showed overexpression of HMGA2 lacking the carboxyterminal tail; deletions covering the 5' end of HMGA2 |
| | |
| Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. |
| Ashar HR, Fejzo MS, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC, Chada K |
| Cell. 1995 ; 82 (1) : 57-65. |
| PMID 7606786 |
| |
| Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene. |
| Kazmierczak B, Hennig Y, Wanschura S, Rogalla P, Bartnitzke S, Van de Ven W, Bullerdiek J |
| Cancer research. 1995 ; 55 (24) : 6038-6039. |
| PMID 8521389 |
| |
| Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. |
| Schoenmakers EF, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H, Van de Ven WJ |
| Nature genetics. 1995 ; 10 (4) : 436-444. |
| PMID 7670494 |
| |
| Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. |
| Zhou X, Benson KF, Ashar HR, Chada K |
| Nature. 1995 ; 376 (6543) : 771-774. |
| PMID 7651535 |
| |
| Fusion transcripts between the HMGIC gene and RTVL-H-related sequences in mesenchymal tumors without cytogenetic aberrations. |
| Kazmierczak B, Pohnke Y, Bullerdiek J |
| Genomics. 1996 ; 38 (2) : 223-226. |
| PMID 8954805 |
| |
| Amplification of a rearranged form of the high-mobility group protein gene HMGIC in OsA-CI osteosarcoma cells. |
| Kools PF, Van de Ven WJ |
| Cancer genetics and cytogenetics. 1996 ; 91 (1) : 1-7. |
| PMID 8908160 |
| |
| LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. |
| Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van de Ven WJ |
| Genomics. 1996 ; 36 (1) : 118-129. |
| PMID 8812423 |
| |
| Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas. |
| Schoenberg Fejzo M, Ashar HR, Krauter KS, Powell WL, Rein MS, Weremowicz S, Yoon SJ, Kucherlapati RS, Chada K, Morton CC |
| Genes, chromosomes & cancer. 1996 ; 17 (1) : 1-6. |
| PMID 8889500 |
| |
| Hidden paracentric inversions of chromosome arm 12q affecting the HMGIC gene. |
| Wanschura S, Dal Cin P, Kazmierczak B, Bartnitzke S, Van den Berghe H, Bullerdiek J |
| Genes, chromosomes & cancer. 1997 ; 18 (4) : 322-323. |
| PMID 9087575 |
| |
| Chromosomal translocations in benign tumors: the HMGI proteins. |
| Hess JL |
| American journal of clinical pathology. 1998 ; 109 (3) : 251-261. |
| PMID 9495195 |
| |
| The t(3;12)(q27;q14-q15) with underlying HMGIC-LPP fusion is not determining an adipocytic phenotype. |
| Rogalla P, Kazmierczak B, Meyer-Bolte K, Tran KH, Bullerdiek J |
| Genes, chromosomes & cancer. 1998 ; 22 (2) : 100-104. |
| PMID 9598796 |
| |
| HMGIC expression in human adult and fetal tissues and in uterine leiomyomata. |
| Gattas GJ, Quade BJ, Nowak RA, Morton CC |
| Genes, chromosomes & cancer. 1999 ; 25 (4) : 316-322. |
| PMID 10398424 |
| |
| Inflammatory myofibroblastic tumor with HMGIC rearrangement. |
| Kazmierczak B, Dal Cin P, Sciot R, Van den Berghe H, Bullerdiek J |
| Cancer genetics and cytogenetics. 1999 ; 112 (2) : 156-160. |
| PMID 10686944 |
| |
| Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas. |
| Schoenmakers EF, Huysmans C, Van de Ven WJ |
| Cancer research. 1999 ; 59 (1) : 19-23. |
| PMID 9892177 |
| |
| In vivo modulation of Hmgic reduces obesity. |
| Anand A, Chada K |
| Nature genetics. 2000 ; 24 (4) : 377-380. |
| PMID 10742101 |
| |
| Transgenic mice expressing a truncated form of the high mobility group I-C protein develop adiposity and an abnormally high prevalence of lipomas. |
| Arlotta P, Tai AK, Manfioletti G, Clifford C, Jay G, Ono SJ |
| The Journal of biological chemistry. 2000 ; 275 (19) : 14394-14400. |
| PMID 10747931 |
| |
| Novel gene fusion of COX6C at 8q22-23 to HMGIC at 12q15 in a uterine leiomyoma. |
| Kurose K, Mine N, Doi D, Ota Y, Yoneyama K, Konishi H, Araki T, Emi M |
| Genes, chromosomes & cancer. 2000 ; 27 (3) : 303-307. |
| PMID 10679920 |
| |
| The expression of HMGA genes is regulated by their 3'UTR. |
| Borrmann L, Wilkening S, Bullerdiek J |
| Oncogene. 2001 ; 20 (33) : 4537-4541. |
| PMID 11494149 |
| |
| Chromosomal rearrangements leading to abnormal splicing within intron 4 of HMGIC? |
| Hauke S, Rippe V, Bullerdiek J |
| Genes, chromosomes & cancer. 2001 ; 30 (3) : 302-304. |
| PMID 11170289 |
| |
| Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas. |
| Kurose K, Mine N, Iida A, Nagai H, Harada H, Araki T, Emi M |
| Genes, chromosomes & cancer. 2001 ; 30 (2) : 212-217. |
| PMID 11135440 |
| |
| Ectopic sequences from truncated HMGIC in liposarcomas are derived from various amplified chromosomal regions. |
| Meza-Zepeda LA, Berner JM, Henriksen J, South AP, Pedeutour F, Dahlberg AB, Godager LH, Nizetic D, Forus A, Myklebost O |
| Genes, chromosomes & cancer. 2001 ; 31 (3) : 264-273. |
| PMID 11391797 |
| |
| Fusion of a sequence from HEI10 (14q11) to the HMGIC gene at 12q15 in a uterine leiomyoma. |
| Mine N, Kurose K, Konishi H, Araki T, Nagai H, Emi M |
| Japanese journal of cancer research : Gann. 2001 ; 92 (2) : 135-139. |
| PMID 11223542 |
| |
| Chromosomal translocation t(8;12) induces aberrant HMGIC expression in aggressive angiomyxoma of the vulva. |
| Nucci MR, Weremowicz S, Neskey DM, Sornberger K, Tallini G, Morton CC, Quade BJ |
| Genes, chromosomes & cancer. 2001 ; 32 (2) : 172-176. |
| PMID 11550285 |
| |
| Evidence for RAD51L1/HMGIC fusion in the pathogenesis of uterine leiomyoma. |
| Takahashi T, Nagai N, Oda H, Ohama K, Kamada N, Miyagawa K |
| Genes, chromosomes & cancer. 2001 ; 30 (2) : 196-201. |
| PMID 11135437 |
| |
| Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15. |
| Broberg K, Zhang M, Strˆmbeck B, Isaksson M, Nilsson M, Mertens F, Mandahl N, Panagopoulos I |
| International journal of oncology. 2002 ; 21 (2) : 321-326. |
| PMID 12118328 |
| |
| HMGA1 and HMGA2 protein expression in mouse spermatogenesis. |
| Chieffi P, Battista S, Barchi M, Di Agostino S, Pierantoni GM, Fedele M, Chiariotti L, Tramontano D, Fusco A |
| Oncogene. 2002 ; 21 (22) : 3644-3650. |
| PMID 12032866 |
| |
| Hyaline vascular Castleman's disease with HMGIC rearrangement in follicular dendritic cells: molecular evidence of mesenchymal tumorigenesis. |
| Cokelaere K, Debiec-Rychter M, De Wolf-Peeters C, Hagemeijer A, Sciot R |
| The American journal of surgical pathology. 2002 ; 26 (5) : 662-669. |
| PMID 11979097 |
| |
| Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas. |
| Fedele M, Battista S, Kenyon L, Baldassarre G, Fidanza V, Klein-Szanto AJ, Parlow AF, Visone R, Pierantoni GM, Outwater E, Santoro M, Croce CM, Fusco A |
| Oncogene. 2002 ; 21 (20) : 3190-3198. |
| PMID 12082634 |
| |
| The High Mobility Group A2 gene is amplified and overexpressed in human prolactinomas. |
| Finelli P, Pierantoni GM, Giardino D, Losa M, Rodeschini O, Fedele M, Valtorta E, Mortini P, Croce CM, Larizza L, Fusco A |
| Cancer research. 2002 ; 62 (8) : 2398-2405. |
| PMID 11956103 |
| |
| Sequencing of intron 3 of HMGA2 uncovers the existence of a novel exon. |
| Hauke S, Flohr AM, Rogalla P, Bullerdiek J |
| Genes, chromosomes & cancer. 2002 ; 34 (1) : 17-23. |
| PMID 11921278 |
| |
| Expression of the HMGA2-LPP fusion transcript in only 1 of 61 karyotypically normal pulmonary chondroid hamartomas. |
| Lemke I, Rogalla P, Grundmann F, Kunze WP, Haupt R, Bullerdiek J |
| Cancer genetics and cytogenetics. 2002 ; 138 (2) : 160-164. |
| PMID 12505264 |
| |
| Absence of HMGIC-LHFP fusion in pulmonary chondroid hamartomas with aberrations involving chromosomal regions 12q13 through 15 and 13q12 through q14. |
| Rogalla P, Lemke I, Bullerdiek J |
| Cancer genetics and cytogenetics. 2002 ; 133 (1) : 90-93. |
| PMID 11890997 |
| |
| Translocation of the HMGI-C ( HMGA2) gene in a benign mesenchymoma (chondrolipoangioma). |
| Van Dorpe J, Dal Cin P, Weremowicz S, Van Leuven F, de Wever I, Van den Berghe H, Fletcher CD, Sciot R |
| Virchows Archiv : an international journal of pathology. 2002 ; 440 (5) : 485-490. |
| PMID 12021922 |
| |
| An increased high-mobility group A2 expression level is associated with malignant phenotype in pancreatic exocrine tissue. |
| Abe N, Watanabe T, Suzuki Y, Matsumoto N, Masaki T, Mori T, Sugiyama M, Chiappetta G, Fusco A, Atomi Y |
| British journal of cancer. 2003 ; 89 (11) : 2104-2109. |
| PMID 14647145 |
| |
| Human HMGA2 promoter is coregulated by a polymorphic dinucleotide (TC)-repeat. |
| Borrmann L, Seebeck B, Rogalla P, Bullerdiek J |
| Oncogene. 2003 ; 22 (5) : 756-760. |
| PMID 12569368 |
| |
| Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. |
| Dahlˆ©n A, Mertens F, Rydholm A, Brosjˆ O, Wejde J, Mandahl N, Panagopoulos I |
| Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2003 ; 16 (11) : 1132-1140. |
| PMID 14614053 |
| |
| HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia. |
| Pierantoni GM, Santulli B, Caliendo I, Pentimalli F, Chiappetta G, Zanesi N, Santoro M, Bulrich F, Fusco A |
| International journal of oncology. 2003 ; 23 (2) : 363-367. |
| PMID 12851685 |
| |
| Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15. |
| Quade BJ, Weremowicz S, Neskey DM, Vanni R, Ladd C, Dal Cin P, Morton CC |
| Cancer research. 2003 ; 63 (6) : 1351-1358. |
| PMID 12649198 |
| |
| High mobility group I-C protein in astrocytoma and glioblastoma. |
| Akai T, Ueda Y, Sasagawa Y, Hamada T, Date T, Katsuda S, Iizuka H, Okada Y, Chada K |
| Pathology, research and practice. 2004 ; 200 (9) : 619-624. |
| PMID 15497774 |
| |
| Dysregulation and overexpression of HMGA2 in myelofibrosis with myeloid metaplasia. |
| Andrieux J, Demory JL, Dupriez B, Quief S, Plantier I, Roumier C, Bauters F, LaˆØ JL, Kerckaert JP |
| Genes, chromosomes & cancer. 2004 ; 39 (1) : 82-87. |
| PMID 14603445 |
| |
| HMGA molecules in neuroblastic tumors. |
| Cerignoli F, Ambrosi C, Mellone M, Assimi I, di Marcotullio L, Gulino A, Giannini G |
| Annals of the New York Academy of Sciences. 2004 ; 1028 : 122-132. |
| PMID 15650238 |
| |
| Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity. |
| Miyazawa J, Mitoro A, Kawashiri S, Chada KK, Imai K |
| Cancer research. 2004 ; 64 (6) : 2024-2029. |
| PMID 15026339 |
| |
| Array comparative genomic hybridization analysis of uterine leiomyosarcoma. |
| Cho YL, Bae S, Koo MS, Kim KM, Chun HJ, Kim CK, Ro DY, Kim JH, Lee CH, Kim YW, Ahn WS |
| Gynecologic oncology. 2005 ; 99 (3) : 545-551. |
| PMID 16125217 |
| |
| Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2. |
| Crombez KR, Vanoirbeek EM, Van de Ven WJ, Petit MM |
| Molecular cancer research : MCR. 2005 ; 3 (2) : 63-70. |
| PMID 15755872 |
| |
| HMGA proteins in malignant peripheral nerve sheath tumor and synovial sarcoma: preferential expression of HMGA2 in malignant peripheral nerve sheath tumor. |
| Hui P, Li N, Johnson C, De Wever I, Sciot R, Manfioletti G, Tallini G |
| Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2005 ; 18 (11) : 1519-1526. |
| PMID 16056249 |
| |
| Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas. |
| Ligon AH, Moore SD, Parisi MA, Mealiffe ME, Harris DJ, Ferguson HL, Quade BJ, Morton CC |
| American journal of human genetics. 2005 ; 76 (2) : 340-348. |
| PMID 15593017 |
| |
| Fusion of the HMGA2 and NFIB genes in lipoma. |
| Nilsson M, Panagopoulos I, Mertens F, Mandahl N |
| Virchows Archiv : an international journal of pathology. 2005 ; 447 (5) : 855-858. |
| PMID 16133369 |
| |
| Frequent deletions at 12q14.3 chromosomal locus in adult acute lymphoblastic leukemia. |
| Patel HS, Kantarjian HM, Bueso-Ramos CE, Medeiros LJ, Haidar MA |
| Genes, chromosomes & cancer. 2005 ; 42 (1) : 87-94. |
| PMID 15495192 |
| |
