Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

WNT5A (wingless-type MMTV integration site family, member 5A)

Identity

Other namesWNT-5A
HGNC (Hugo) WNT5A
LocusID (NCBI) 7474
Location 3p14.3
Location_base_pair Starts at 55499743 and ends at 55515426 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Local_order CACNA2D3 - WNT5A - ERC2
Note WNT family ligand. WNT family members with conserved 22 or 24 Cys residues are secreted-type glycoproteins, which are implicated in embryogenesis and carcinogenesis. Nineteen WNT family genes exist within the human genome.

DNA/RNA

Note WNT5A gene at chromosome 3p14.3 and WNT5B gene at chromosome 12p13.33 are paralogs within the human genome.
 
  Schematic representation of WNT5A gene.
Note [Annexed document]
  Alignment of mammalian WNT5A and WNT5B orthologs. N-terminal signal peptide (double over-line), conserved Cys residues (+), and Asn-linked glycosylation sites are shown.
Description WNT5A gene consists of 5 exons. First methionine is located in exon 1, while stop codon in exon 5. dbSNP rs655731, located within exon 5 of the human WNT5A gene, is a synonymous SNP corresponding to codon 263.
Transcription WNT5A is preferentially upregulated in gastric cancer, and melanoma, but downregulated in breast cancer, colorectal cancer, and acute lymphocytic leukemia.
Wnt5a is upregulated by IL6 family cytokines through gp130 in cultured cardiomyocytes, by TGFbeta in mammary epithelial cells, and by TNFalpha in gastric cancer cells. WNT5A upregulation in primary tumor is in part due to stromal expression based on tumor-stromal interaction, while WNT5A downregulation in primary tumor is in part due to epigenetic silencing induced by promoter CpG hypermethylation.

Protein

Description Mature WNT5A protein with conserved Cys residues is a secreted-type glycoprotein.
Expression WNT5A mRNA is relatively abundantly expressed in salivary gland, bladder, uterus, placenta, and fetal kidney.
Localisation Naive WNT5A protein is synthesized in the endoplasmic reticulum. Mature WNT5A protein with lipid modifications and glycosylations enters the trans-Golgi network for secretion from the cell surface.
Function WNT5A signals are transduced to the canonical and non-canonical WNT signaling cascades. WNT5A signaling through Frizzled-4 ( FZD4 ) or FZD5 receptor and LRP5 or LRP6 co-receptor leads to the stabilization and nuclear accumulation of beta-catenin for the transcriptional activation of target genes, such as MYC, CCND1, and FGF20. On the other hand, WNT5A signaling through Frizzled family receptor or ROR1 or ROR2 co-receptor leads to the activation of the non-canonical WNT signaling cascades, such as DAG - PKC, IP3 - NFAT, or IP3 - NLK signaling cascades. WNT5A-PKC signaling promotes invasion and metastasis of tumors through SNAI1 (Snail)-mediated epithelial-to-mesenchymal transition (EMT), while WNT5A-NLK signaling suppresses carcinogenesis through inhibition of the canonical WNT signaling cascade. Expression of WNT5A is associated with metastatic or aggressive phenotype in gastric cancer, melanoma, and osteosarcoma, but is associated with non-aggressive or better prognostic phenotype in breast cancer, colorectal cancer, and acute lymphocytic leukemia. Together these facts indicate that WNT5A induces oncogenic as well as tumor suppressive functions in a context-dependent manner.
Homology Human WNT5A shows 98.7% total amino-acid identity with rodent Wnt5a, indicating that mammalian WNT5A orthologs are highly conserved. Among 19 WNT family members, WNT5A is most homologous to WNT5B.

Mutations

Note WNT5A gene is located at human chromosome 3p14.3 around the susceptible locus of Zimmermann-Laband Syndrome; however, mutation of WNT5A gene has not been detected.
Germinal Wnt5a knockout mice show smaller somites and shortened presomitic mesoderm, abnormalities in the lungs with the foreshortened trachea, dysplasia of genitals, and ventricular septal defects.

Implicated in

Entity Melanoma
Prognosis Poor prognosis
  
Entity Gastric cancer
Prognosis Poor prognosis
  
Entity Osteosarcoma
Prognosis Poor prognosis
  
Entity Breast cancer
Prognosis Better prognosis
  
Entity Colorectal cancer
Prognosis Better prognosis
  
Entity Acute lymphocytic leukemia
Prognosis Better prognosis
  

External links

Nomenclature
HGNC (Hugo)WNT5A   12784
Entrez_Gene (NCBI)WNT5A  7474  wingless-type MMTV integration site family, member 5A
Cards
AtlasWNT5AID42825ch3p14
GeneCards (Weizmann)WNT5A
Ensembl (Hinxton)ENSG00000114251 [Gene_View]  chr3:55499743-55515426 [Contig_View]  WNT5A [Vega]
AceView (NCBI)WNT5A
Genatlas (Paris)WNT5A
euGene (Indiana)7474
SOURCE (Stanford)NM_001256105 NM_003392
Genomic and cartography
GoldenPath (UCSC)WNT5A  -  3p14.3   chr3:55499743-55515426 -  3p21-p14   [Description]    (hg19-Feb_2009)
EnsemblWNT5A - 3p21-p14 [CytoView]
Mapping of homologs : NCBIWNT5A [Mapview]
OMIM164975   180700   
Gene and transcription
Genbank (Entrez)AI634753 AK021503 AK090582 AK290375 AK290869
RefSeq transcript (SRS)NM_001256105 NM_003392
RefSeq transcript (Entrez)NM_001256105 NM_003392
RefSeq genomic (SRS)AC_000135 NC_000003 NG_031992 NT_022517 NW_001838877
RefSeq genomic (Entrez)AC_000135 NC_000003 NG_031992 NT_022517 NW_001838877
Consensus coding sequences : CCDS (NCBI)WNT5A
Cluster EST : UnigeneHs.643085 [ SRS ] Hs.643085 [ NCBI ]
Alternative Splicing : Fast-db (Paris)8589
Alternative Splicing GalleryENSG00000114251
Gene ExpressionWNT5A [ NCBI-GEO ]   WNT5A [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41221 (SRS) P41221 (Uniprot)
With graphics : InterProP41221
Splice isoforms : SwissVarP41221(Swissvar)
Domaine pattern : Prosite (SRS)WNT1 (PS00246)   
Domaine pattern : Prosite (Expaxy)WNT1 (PS00246)   
Domains : Interpro (SRS)Wnt    Wnt_grthfactor_CS   
Domains : Interpro (EBI)Wnt    Wnt_grthfactor_CS   
Related proteins : CluSTrP41221
Domain families : Pfam (SRS)wnt (PF00110)   
Domain families : Pfam (Sanger)wnt (PF00110)   
Domain families : Pfam (NCBI)pfam00110   
Domain families : Smart (EMBL)WNT1 (SM00097)  
Blocks (Seattle)P41221
Human Protein AtlasENSG00000114251
HPRD01293
IPIIPI00795811   IPI00013178   IPI00807634   IPI00985138   
Protein Interaction databases
DIP (DOE-UCLA)P41221
IntAct (EBI)P41221
FunCoupENSG00000114251
REACTOMEWNT5A
BioGRIDWNT5A
InParanoidP41221
Interologous Interaction database P41221
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)WNT5A
SNP (GeneSNP Utah)WNT5A
SNP : HGBaseWNT5A
Genetic variants : HAPMAPWNT5A
Somatic Mutations in Cancer : COSMICWNT5A 
CONAN: Copy Number AnalysisWNT5A 
Mutations and Diseases : HGMDWNT5A
OMIM164975    180700   
GENETests164975    180700   
Disease Genetic AssociationWNT5A
Huge Navigator WNT5A [HugePedia]  WNT5A [HugeCancerGEM]
Genomic VariantsWNT5A
snp3D : Map Gene to Disease7474
General knowledge
Homologs : HomoloGeneWNT5A
Homology/Alignments : Family Browser (UCSC)WNT5A
Phylogenetic Trees/Animal Genes : TreeFamWNT5A
Chemical/Protein Interactions : CTD7474
Chemical/Pharm GKB GenePA37385
Clinical trialWNT5A
Cancer Resource (Charite)ENSG00000114251
Ontology : AmiGOactivation of MAPK activity  ameboidal cell migration  establishment of planar polarity  somitogenesis  epithelial to mesenchymal transition  neural tube closure  positive regulation of endothelial cell proliferation  heart looping  positive regulation of mesenchymal cell proliferation  lens development in camera-type eye  positive regulation of cytokine secretion involved in immune response  type B pancreatic cell development  pericardium morphogenesis  axis elongation  optic cup formation involved in camera-type eye development  sequence-specific DNA binding transcription factor activity  receptor binding  frizzled binding  frizzled-2 binding  receptor tyrosine kinase-like orphan receptor binding  cytokine activity  extracellular region  proteinaceous extracellular matrix  extracellular space  membrane fraction  cytoplasm  plasma membrane  signal transduction  Wnt receptor signaling pathway, calcium modulating pathway  Wnt receptor signaling pathway, calcium modulating pathway  activation of JUN kinase activity  activation of JUN kinase activity  multicellular organismal development  axon guidance  hindgut morphogenesis  midgut development  male gonad development  anterior/posterior axis specification, embryo  embryo development  dorsal/ventral axis specification  cell surface  response to organic substance  positive regulation of endothelial cell migration  positive regulation of peptidyl-threonine phosphorylation  positive regulation of T cell chemotaxis  positive regulation of neuron projection development  response to organic cyclic compound  Wnt receptor signaling pathway  Wnt receptor signaling pathway  protein domain specific binding  olfactory bulb interneuron development  neural tube development  neuron differentiation  keratinocyte differentiation  negative regulation of BMP signaling pathway  positive regulation of cGMP metabolic process  prostate gland development  activation of protein kinase B activity  response to estradiol stimulus  positive regulation of interferon-gamma production  positive regulation of interleukin-6 production  positive regulation of peptidyl-serine phosphorylation  response to testosterone stimulus  cellular protein localization  tail morphogenesis  negative regulation of fibroblast growth factor receptor signaling pathway  wound healing  embryonic digit morphogenesis  positive regulation of macrophage activation  negative regulation of apoptotic process  transcription regulatory region DNA binding  positive regulation of chemokine biosynthetic process  negative regulation of fat cell differentiation  positive regulation of protein catabolic process  positive regulation of angiogenesis  positive regulation of ossification  positive regulation of meiosis  negative regulation of transcription, DNA-dependent  positive regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  receptor agonist activity  positive regulation of fibroblast proliferation  lung alveolus development  digestive tract morphogenesis  embryonic skeletal system development  genitalia development  neuron projection morphogenesis  negative regulation of axon extension involved in axon guidance  hypophysis morphogenesis  negative regulation of epithelial cell proliferation  positive regulation of interleukin-1 beta secretion  positive regulation of inflammatory response  negative chemotaxis  positive regulation of NF-kappaB transcription factor activity  response to glucocorticoid stimulus  negative regulation of synapse assembly  response to hyperoxia  palate development  convergent extension involved in organogenesis  uterus development  cervix development  vagina development  Wnt receptor signaling pathway, planar cell polarity pathway  urinary bladder development  metestrus  face development  positive regulation of type I interferon-mediated signaling pathway  respiratory system development  lateral sprouting involved in mammary gland duct morphogenesis  mesenchymal-epithelial cell signaling  negative regulation of prostatic bud formation  mammary gland branching involved in thelarche  epithelial cell proliferation involved in mammary gland duct elongation  positive regulation of response to cytokine stimulus  regulation of branching involved in mammary gland duct morphogenesis  positive regulation of macrophage cytokine production  positive regulation of cartilage development  planar cell polarity pathway involved in outflow tract morphogenesis  planar cell polarity pathway involved in ventricular septum morphogenesis  planar cell polarity pathway involved in cardiac right atrium morphogenesis  planar cell polarity pathway involved in cardiac muscle tissue morphogenesis  planar cell polarity pathway involved in pericardium morphogenesis  positive regulation of thymocyte apoptosis  cellular response to lipopolysaccharide  cellular response to calcium ion  cellular response to retinoic acid  cellular response to interferon-gamma  hemopoietic stem cell proliferation  dopaminergic neuron differentiation  cellular response to transforming growth factor beta stimulus  negative regulation of mesenchymal cell proliferation  primitive streak formation  positive regulation of protein kinase C signaling cascade  negative regulation of canonical Wnt receptor signaling pathway  negative regulation of canonical Wnt receptor signaling pathway  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  positive regulation of cell-cell adhesion mediated by cadherin  positive regulation of interleukin-8 secretion  
Ontology : EGO-EBIactivation of MAPK activity  ameboidal cell migration  establishment of planar polarity  somitogenesis  epithelial to mesenchymal transition  neural tube closure  positive regulation of endothelial cell proliferation  heart looping  positive regulation of mesenchymal cell proliferation  lens development in camera-type eye  positive regulation of cytokine secretion involved in immune response  type B pancreatic cell development  pericardium morphogenesis  axis elongation  optic cup formation involved in camera-type eye development  sequence-specific DNA binding transcription factor activity  receptor binding  frizzled binding  frizzled-2 binding  receptor tyrosine kinase-like orphan receptor binding  cytokine activity  extracellular region  proteinaceous extracellular matrix  extracellular space  membrane fraction  cytoplasm  plasma membrane  signal transduction  Wnt receptor signaling pathway, calcium modulating pathway  Wnt receptor signaling pathway, calcium modulating pathway  activation of JUN kinase activity  activation of JUN kinase activity  multicellular organismal development  axon guidance  hindgut morphogenesis  midgut development  male gonad development  anterior/posterior axis specification, embryo  embryo development  dorsal/ventral axis specification  cell surface  response to organic substance  positive regulation of endothelial cell migration  positive regulation of peptidyl-threonine phosphorylation  positive regulation of T cell chemotaxis  positive regulation of neuron projection development  response to organic cyclic compound  Wnt receptor signaling pathway  Wnt receptor signaling pathway  protein domain specific binding  olfactory bulb interneuron development  neural tube development  neuron differentiation  keratinocyte differentiation  negative regulation of BMP signaling pathway  positive regulation of cGMP metabolic process  prostate gland development  activation of protein kinase B activity  response to estradiol stimulus  positive regulation of interferon-gamma production  positive regulation of interleukin-6 production  positive regulation of peptidyl-serine phosphorylation  response to testosterone stimulus  cellular protein localization  tail morphogenesis  negative regulation of fibroblast growth factor receptor signaling pathway  wound healing  embryonic digit morphogenesis  positive regulation of macrophage activation  negative regulation of apoptotic process  transcription regulatory region DNA binding  positive regulation of chemokine biosynthetic process  negative regulation of fat cell differentiation  positive regulation of protein catabolic process  positive regulation of angiogenesis  positive regulation of ossification  positive regulation of meiosis  negative regulation of transcription, DNA-dependent  positive regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  receptor agonist activity  positive regulation of fibroblast proliferation  lung alveolus development  digestive tract morphogenesis  embryonic skeletal system development  genitalia development  neuron projection morphogenesis  negative regulation of axon extension involved in axon guidance  hypophysis morphogenesis  negative regulation of epithelial cell proliferation  positive regulation of interleukin-1 beta secretion  positive regulation of inflammatory response  negative chemotaxis  positive regulation of NF-kappaB transcription factor activity  response to glucocorticoid stimulus  negative regulation of synapse assembly  response to hyperoxia  palate development  convergent extension involved in organogenesis  uterus development  cervix development  vagina development  Wnt receptor signaling pathway, planar cell polarity pathway  urinary bladder development  metestrus  face development  positive regulation of type I interferon-mediated signaling pathway  respiratory system development  lateral sprouting involved in mammary gland duct morphogenesis  mesenchymal-epithelial cell signaling  negative regulation of prostatic bud formation  mammary gland branching involved in thelarche  epithelial cell proliferation involved in mammary gland duct elongation  positive regulation of response to cytokine stimulus  regulation of branching involved in mammary gland duct morphogenesis  positive regulation of macrophage cytokine production  positive regulation of cartilage development  planar cell polarity pathway involved in outflow tract morphogenesis  planar cell polarity pathway involved in ventricular septum morphogenesis  planar cell polarity pathway involved in cardiac right atrium morphogenesis  planar cell polarity pathway involved in cardiac muscle tissue morphogenesis  planar cell polarity pathway involved in pericardium morphogenesis  positive regulation of thymocyte apoptosis  cellular response to lipopolysaccharide  cellular response to calcium ion  cellular response to retinoic acid  cellular response to interferon-gamma  hemopoietic stem cell proliferation  dopaminergic neuron differentiation  cellular response to transforming growth factor beta stimulus  negative regulation of mesenchymal cell proliferation  primitive streak formation  positive regulation of protein kinase C signaling cascade  negative regulation of canonical Wnt receptor signaling pathway  negative regulation of canonical Wnt receptor signaling pathway  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  positive regulation of cell-cell adhesion mediated by cadherin  positive regulation of interleukin-8 secretion  
Pathways : KEGGHedgehog signaling pathwayWnt signaling pathway
Other databases
Probes
Probes : ImagenesWNT5A Related clones (RZPD - Berlin)
Litterature
PubMed138 Pubmed reference(s) in Entrez
PubGeneWNT5A
iHOPWNT5A

Bibliography

Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21.
Clark CC, Cohen I, Eichstetter I, Cannizzaro LA, McPherson JD, Wasmuth JJ, Iozzo RV.
Genomics 1993; 18: 249-260.
PMID 8288227
 
Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes.
Dealy CN, Roth A, Ferrari D, Brown AM, Kosher RA.
Mech Dev 1993; 43: 175-186.
PMID 8297789
 
Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis.
Moon RT, Campbell RM, Christian JL, McGrew LL, Shih J, Fraser S.
Development 1993; 119: 97-111.
PMID 8275867
 
Differential transformation of mammary epithelial cells by Wnt genes.
Wong GT, Gavin BJ, McMahon AP.
Mol Cell Biol 1994; 14: 6278-6286.
PMID 8065359
 
Aberrant expression of the growth factor Wnt-5A in human malignancy.
Iozzo RV, Eichstetter I, Danielson KG.
Cancer Res 1995; 55: 3495-3499.
PMID 7627953
 
Wnt5a cloning, expression, and up-regulation in human primary breast cancers.
Lejeune S, Huguet EL, Hamby A, Poulsom R, Harris AL.
Clin Cancer Res 1995; 1: 215-222.
PMID 9815976
 
A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells.
Austin TW, Solar GP, Ziegler FC, Liem L, Matthews W.
Blood 1997; 89: 3624-3635.
PMID 9160667
 
Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma.
Bui TD, Zhang L, Rees MC, Bicknell R, Harris AL.
Br J Cancer 1997; 75: 1131-1136.
PMID 9099960
 
A member of the Frizzled protein family mediating axis induction by Wnt-5A.
He X, Saint-Jeannet JP, Wang Y, Nathans J, Dawid I, Varmus H.
Science 1997; 275: 1652-1654.
PMID 9054360
 
Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A.
Slusarski DC, Yang-Snyder J, Busa WB, Moon RT.
Dev Biol 1997; 182: 114-120.
PMID 9073455
 
Identification of c-MYC as a target of the APC pathway.
He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW.
Science 1998; 281: 1509-1512.
PMID 9727977
 
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.
Tetsu O, McCormick F.
Nature 1999; 398: 422-426.
PMID 10201372
 
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.
Yamaguchi TP, Bradley A, McMahon AP, Jones S.
Development 1999; 126: 1211-1123.
PMID 10021340
 
Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas.
Jonsson M, Dejmek J, Bendahl PO, Andersson T.
Cancer Res 2002; 62: 409-416.
PMID 11809689
 
Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFa in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells.
Saitoh T, Katoh M.
Int J Mol Med 2002; 10: 345-349.
PMID 12165812
 
Frequent up-regulation of WNT5A mRNA in primary gastric cancer.
Saitoh T, Mine T, Katoh M.
Int J Mol Med 2002; 9: 515-519.
PMID 11956659
 
Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma.
Weeraratna AT, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M, Trent JM.
Cancer Cell 2002; 1: 279-288.
PMID 12086864
 
Gene-expression profiling in human cutaneous melanoma.
Carr KM, Bittner M, Trent JM.
Oncogene 2003; 22: 3076-3080.
PMID 12789283
 
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.
Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y.
Genes Cells 2003; 8: 645-654.
PMID 12839624
 
Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes.
Fujio Y, Matsuda T, Oshima Y, Maeda M, Mohri T, Ito T, Takatani T, Hirata M, Nakaoka Y, Kimura R, Kishimoto T, Azuma J.
FEBS Lett 2004 Aug; 573: 202-206.
PMID 15327998
 
FGF20 and DKK1 are transcriptional targets of beta-catenin and FGF20 is implicated in cancer and development.
Chamorro MN, Schwartz DR, Vonica A, Brivanlou AH, Cho KR, Varmus HE.
EMBO J 2005; 24: 73-84.
PMID 15592430
 
Expression pattern of Wnt signaling components in the adult intestine.
Gregorieff A, Pinto D, Begthel H, Destrée O, Kielman M, Clevers H.
Gastroenterology 2005; 129: 626-638.
PMID 16083717
 
WNT/PCP signaling pathway and human cancer.
Katoh M.
Oncol Rep 2005; 14: 1583-1588. (Review)
PMID 16273260
 
Comparative genomics on Wnt5a and Wnt5b genes.
Katoh M, Katoh M.
Int J Mol Med 2005; 15: 749-753.
PMID 15754042
 
Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1a signaling in human mammary epithelial cells.
Dejmek J, Säfholm A, Kamp Nielsen C, Andersson T, Leandersson K.
Mol Cell Biol 2006; 26: 6024-6036.
PMID 16880514
 
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.
Mikels AJ, Nusse R.
PLoS Biol 2006; 4: e115.
PMID 16602827
 
Wnt5a signaling is critical for macrophage-induced invasion of breast cancer cell lines.
Pukrop T, Klemm F, Hagemann T, Gradl D, Schulz M, Siemes S, Trumper L, Binder C.
Proc Natl Acad Sci USA 2006; 103: 5454-5459.
PMID 16569699
 
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.
Dissanayake SK, Wade M, Johnson CE, O'Connell MP, Leotlela PD, French AD, Shah KV, Hewitt KJ, Rosenthal DT, Indig FE, Jiang Y, Nickoloff BJ, Taub DD, Trent JM, Moon RT, Bittner M, Weeraratna AT.
J Biol Chem 2007; 282:17259-17271.
PMID 17426020
 
STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis, and cancer.
Katoh M, Katoh M.
Int J Mol Med 2007; 19: 273-278. (Review).
PMID 17203201
 
Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth.
Roarty K, Serra R.
Development 2007; 134: 3929-3939.
PMID 17898001
 
Expression of WNT5A and its downstream effector beta-catenin in uveal melanoma.
Zuidervaart W, Pavey S, van Nieuwpoort FA, Packer L, Out C, Maat W, Jager MJ, Gruis NA, Hayward NK.
Melanoma Res 2007; 17: 380-386.
PMID 17992121
 
Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration
Cheng C, Yeh J, Fan T, Smith SK, Charnock-Jones DS.
Biochem Biophys Res Commun 2008; 365: 285-290.
PMID 17986384
 
Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a.
Fukuda T, Chen L, Endo T, Tang L, Lu D, Castro JE, Widhopf GF 2nd, Rassenti LZ, Cantwell MJ, Prussak CE, Carson DA, Kipps TJ.
Proc Natl Acad Sci USA 2008; 105: 3047-3052.
PMID 18287027
 
Activation of Wnt signalling in stroma from pancreatic cancer identified by gene expression profiling.
Pilarsky C, Ammerpohl O, Sipos B, Dahl E, Hartmann A, Wellmann A, Braunschweig T, Lohr M, Jesnowski R, Friess H, Wente MN, Kristiansen G, Jahnke B, Denz A, Ruckert F, Schackert HK, Kloppel G, Kalthoff H, Saeger HD, Grutzmann R.
J Cell Mol Med 2008; in press.
PMID 18298655
 
Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors.
Witze ES, Litman ES, Argast GM, Moon RT, Ahn NG.
Science 2008; 320: 365-369.
PMID 18420933
 
WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt/beta-catenin signaling, and is frequently methylated in colorectal cancer.
Ying J, Li H, Yu J, Ng KM, Poon FF, Wong SC, Chan AT, Sung JJ, Tao Q.
Clin Cancer Res 2008; 14: 55-61.
PMID 18172252
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written06-2008Masaru Katoh
Genetics and Cell Biology Section, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan

Citation

This paper should be referenced as such :
Katoh M . WNT5A (wingless-type MMTV integration site family, member 5A). Atlas Genet Cytogenet Oncol Haematol. June 2008 .
URL : http://AtlasGeneticsOncology.org/Genes/WNT5AID42825ch3p14.html

This paper is referenced by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/44474/1/06-2008-WNT5AID42825ch3p14.pdf   [ Bibliographic record ]

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 28 15:10:27 CEST 2012
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.