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WNT5A (wingless-type MMTV integration site family, member 5A)

Written2008-06Masaru Katoh
Genetics, Cell Biology Section, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan

(Note : for Links provided by Atlas : click)

Identity

Alias_nameswingless-type MMTV integration site family
Alias_symbol (synonym)hWNT5A
Other aliasWNT-5A
HGNC (Hugo) WNT5A
LocusID (NCBI) 7474
Atlas_Id 42825
Location 3p14.3  [Link to chromosome band 3p14]
Location_base_pair Starts at 55465715 and ends at 55481398 bp from pter ( according to hg19-Feb_2009)  [Mapping WNT5A.png]
Local_order CACNA2D3 - WNT5A - ERC2
Fusion genes
(updated 2016)		RASA1 (5q14.3) / WNT5A (3p14.3)WNT5A (3p14.3) / WNT5A (3p14.3)
Note WNT family ligand. WNT family members with conserved 22 or 24 Cys residues are secreted-type glycoproteins, which are implicated in embryogenesis and carcinogenesis. Nineteen WNT family genes exist within the human genome.

DNA/RNA

Note WNT5A gene at chromosome 3p14.3 and WNT5B gene at chromosome 12p13.33 are paralogs within the human genome.
 
  Schematic representation of WNT5A gene.
Note [Annexed document]
  Alignment of mammalian WNT5A and WNT5B orthologs. N-terminal signal peptide (double over-line), conserved Cys residues (+), and Asn-linked glycosylation sites are shown.
Description WNT5A gene consists of 5 exons. First methionine is located in exon 1, while stop codon in exon 5. dbSNP rs655731, located within exon 5 of the human WNT5A gene, is a synonymous SNP corresponding to codon 263.
Transcription WNT5A is preferentially upregulated in gastric cancer, and melanoma, but downregulated in breast cancer, colorectal cancer, and acute lymphocytic leukemia.
Wnt5a is upregulated by IL6 family cytokines through gp130 in cultured cardiomyocytes, by TGFbeta in mammary epithelial cells, and by TNFalpha in gastric cancer cells. WNT5A upregulation in primary tumor is in part due to stromal expression based on tumor-stromal interaction, while WNT5A downregulation in primary tumor is in part due to epigenetic silencing induced by promoter CpG hypermethylation.

Protein

Description Mature WNT5A protein with conserved Cys residues is a secreted-type glycoprotein.
Expression WNT5A mRNA is relatively abundantly expressed in salivary gland, bladder, uterus, placenta, and fetal kidney.
Localisation Naive WNT5A protein is synthesized in the endoplasmic reticulum. Mature WNT5A protein with lipid modifications and glycosylations enters the trans-Golgi network for secretion from the cell surface.
Function WNT5A signals are transduced to the canonical and non-canonical WNT signaling cascades. WNT5A signaling through Frizzled-4 ( FZD4 ) or FZD5 receptor and LRP5 or LRP6 co-receptor leads to the stabilization and nuclear accumulation of beta-catenin for the transcriptional activation of target genes, such as MYC, CCND1, and FGF20. On the other hand, WNT5A signaling through Frizzled family receptor or ROR1 or ROR2 co-receptor leads to the activation of the non-canonical WNT signaling cascades, such as DAG - PKC, IP3 - NFAT, or IP3 - NLK signaling cascades. WNT5A-PKC signaling promotes invasion and metastasis of tumors through SNAI1 (Snail)-mediated epithelial-to-mesenchymal transition (EMT), while WNT5A-NLK signaling suppresses carcinogenesis through inhibition of the canonical WNT signaling cascade. Expression of WNT5A is associated with metastatic or aggressive phenotype in gastric cancer, melanoma, and osteosarcoma, but is associated with non-aggressive or better prognostic phenotype in breast cancer, colorectal cancer, and acute lymphocytic leukemia. Together these facts indicate that WNT5A induces oncogenic as well as tumor suppressive functions in a context-dependent manner.
Homology Human WNT5A shows 98.7% total amino-acid identity with rodent Wnt5a, indicating that mammalian WNT5A orthologs are highly conserved. Among 19 WNT family members, WNT5A is most homologous to WNT5B.

Mutations

Note WNT5A gene is located at human chromosome 3p14.3 around the susceptible locus of Zimmermann-Laband Syndrome; however, mutation of WNT5A gene has not been detected.
Germinal Wnt5a knockout mice show smaller somites and shortened presomitic mesoderm, abnormalities in the lungs with the foreshortened trachea, dysplasia of genitals, and ventricular septal defects.

Implicated in

Note
  
Entity Melanoma
Prognosis Poor prognosis
  
  
Entity Gastric cancer
Prognosis Poor prognosis
  
  
Entity Osteosarcoma
Prognosis Poor prognosis
  
  
Entity Breast cancer
Prognosis Better prognosis
  
  
Entity Colorectal cancer
Prognosis Better prognosis
  
  
Entity Acute lymphocytic leukemia
Prognosis Better prognosis
  

Bibliography

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Austin TW, Solar GP, Ziegler FC, Liem L, Matthews W.
Blood 1997; 89: 3624-3635.
PMID 9160667
 
Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma.
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Br J Cancer 1997; 75: 1131-1136.
PMID 9099960
 
Gene-expression profiling in human cutaneous melanoma.
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Oncogene 2003; 22: 3076-3080.
PMID 12789283
 
FGF20 and DKK1 are transcriptional targets of beta-catenin and FGF20 is implicated in cancer and development.
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EMBO J 2005; 24: 73-84.
PMID 15592430
 
Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration
Cheng C, Yeh J, Fan T, Smith SK, Charnock-Jones DS.
Biochem Biophys Res Commun 2008; 365: 285-290.
PMID 17986384
 
Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21.
Clark CC, Cohen I, Eichstetter I, Cannizzaro LA, McPherson JD, Wasmuth JJ, Iozzo RV.
Genomics 1993; 18: 249-260.
PMID 8288227
 
Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes.
Dealy CN, Roth A, Ferrari D, Brown AM, Kosher RA.
Mech Dev 1993; 43: 175-186.
PMID 8297789
 
Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1a signaling in human mammary epithelial cells.
Dejmek J, Säfholm A, Kamp Nielsen C, Andersson T, Leandersson K.
Mol Cell Biol 2006; 26: 6024-6036.
PMID 16880514
 
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.
Dissanayake SK, Wade M, Johnson CE, O'Connell MP, Leotlela PD, French AD, Shah KV, Hewitt KJ, Rosenthal DT, Indig FE, Jiang Y, Nickoloff BJ, Taub DD, Trent JM, Moon RT, Bittner M, Weeraratna AT.
J Biol Chem 2007; 282:17259-17271.
PMID 17426020
 
Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes.
Fujio Y, Matsuda T, Oshima Y, Maeda M, Mohri T, Ito T, Takatani T, Hirata M, Nakaoka Y, Kimura R, Kishimoto T, Azuma J.
FEBS Lett 2004 Aug; 573: 202-206.
PMID 15327998
 
Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a.
Fukuda T, Chen L, Endo T, Tang L, Lu D, Castro JE, Widhopf GF 2nd, Rassenti LZ, Cantwell MJ, Prussak CE, Carson DA, Kipps TJ.
Proc Natl Acad Sci USA 2008; 105: 3047-3052.
PMID 18287027
 
Expression pattern of Wnt signaling components in the adult intestine.
Gregorieff A, Pinto D, Begthel H, Destrée O, Kielman M, Clevers H.
Gastroenterology 2005; 129: 626-638.
PMID 16083717
 
Identification of c-MYC as a target of the APC pathway.
He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW.
Science 1998; 281: 1509-1512.
PMID 9727977
 
A member of the Frizzled protein family mediating axis induction by Wnt-5A.
He X, Saint-Jeannet JP, Wang Y, Nathans J, Dawid I, Varmus H.
Science 1997; 275: 1652-1654.
PMID 9054360
 
Aberrant expression of the growth factor Wnt-5A in human malignancy.
Iozzo RV, Eichstetter I, Danielson KG.
Cancer Res 1995; 55: 3495-3499.
PMID 7627953
 
Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas.
Jonsson M, Dejmek J, Bendahl PO, Andersson T.
Cancer Res 2002; 62: 409-416.
PMID 11809689
 
STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis, and cancer.
Katoh M, Katoh M.
Int J Mol Med 2007; 19: 273-278. (Review).
PMID 17203201
 
WNT/PCP signaling pathway and human cancer.
Katoh M.
Oncol Rep 2005; 14: 1583-1588. (Review)
PMID 16273260
 
Wnt5a cloning, expression, and up-regulation in human primary breast cancers.
Lejeune S, Huguet EL, Hamby A, Poulsom R, Harris AL.
Clin Cancer Res 1995; 1: 215-222.
PMID 9815976
 
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.
Mikels AJ, Nusse R.
PLoS Biol 2006; 4: e115.
PMID 16602827
 
Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis.
Moon RT, Campbell RM, Christian JL, McGrew LL, Shih J, Fraser S.
Development 1993; 119: 97-111.
PMID 8275867
 
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.
Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y.
Genes Cells 2003; 8: 645-654.
PMID 12839624
 
Activation of Wnt signalling in stroma from pancreatic cancer identified by gene expression profiling.
Pilarsky C, Ammerpohl O, Sipos B, Dahl E, Hartmann A, Wellmann A, Braunschweig T, Lohr M, Jesnowski R, Friess H, Wente MN, Kristiansen G, Jahnke B, Denz A, Ruckert F, Schackert HK, Kloppel G, Kalthoff H, Saeger HD, Grutzmann R.
J Cell Mol Med 2008; in press.
PMID 18298655
 
Wnt5a signaling is critical for macrophage-induced invasion of breast cancer cell lines.
Pukrop T, Klemm F, Hagemann T, Gradl D, Schulz M, Siemes S, Trumper L, Binder C.
Proc Natl Acad Sci USA 2006; 103: 5454-5459.
PMID 16569699
 
Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth.
Roarty K, Serra R.
Development 2007; 134: 3929-3939.
PMID 17898001
 
Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFa in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells.
Saitoh T, Katoh M.
Int J Mol Med 2002; 10: 345-349.
PMID 12165812
 
Frequent up-regulation of WNT5A mRNA in primary gastric cancer.
Saitoh T, Mine T, Katoh M.
Int J Mol Med 2002; 9: 515-519.
PMID 11956659
 
Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A.
Slusarski DC, Yang-Snyder J, Busa WB, Moon RT.
Dev Biol 1997; 182: 114-120.
PMID 9073455
 
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.
Tetsu O, McCormick F.
Nature 1999; 398: 422-426.
PMID 10201372
 
Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma.
Weeraratna AT, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M, Trent JM.
Cancer Cell 2002; 1: 279-288.
PMID 12086864
 
Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors.
Witze ES, Litman ES, Argast GM, Moon RT, Ahn NG.
Science 2008; 320: 365-369.
PMID 18420933
 
Differential transformation of mammary epithelial cells by Wnt genes.
Wong GT, Gavin BJ, McMahon AP.
Mol Cell Biol 1994; 14: 6278-6286.
PMID 8065359
 
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.
Yamaguchi TP, Bradley A, McMahon AP, Jones S.
Development 1999; 126: 1211-1123.
PMID 10021340
 
WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt/beta-catenin signaling, and is frequently methylated in colorectal cancer.
Ying J, Li H, Yu J, Ng KM, Poon FF, Wong SC, Chan AT, Sung JJ, Tao Q.
Clin Cancer Res 2008; 14: 55-61.
PMID 18172252
 
Expression of WNT5A and its downstream effector beta-catenin in uveal melanoma.
Zuidervaart W, Pavey S, van Nieuwpoort FA, Packer L, Out C, Maat W, Jager MJ, Gruis NA, Hayward NK.
Melanoma Res 2007; 17: 380-386.
PMID 17992121
 

Citation

This paper should be referenced as such :
Katoh, M
WNT5A (wingless-type MMTV integration site family, member 5A)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(5):371-373.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/WNT5AID42825ch3p14.html

External links

Nomenclature
HGNC (Hugo)WNT5A   12784
Cards
AtlasWNT5AID42825ch3p14
Entrez_Gene (NCBI)WNT5A  7474  Wnt family member 5A
AliaseshWNT5A
GeneCards (Weizmann)WNT5A
Ensembl hg19 (Hinxton)ENSG00000114251 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114251 [Gene_View]  chr3:55465715-55481398 [Contig_View]  WNT5A [Vega]
ICGC DataPortalENSG00000114251
TCGA cBioPortalWNT5A
AceView (NCBI)WNT5A
Genatlas (Paris)WNT5A
WikiGenes7474
SOURCE (Princeton)WNT5A
Genetics Home Reference (NIH)WNT5A
Genomic and cartography
GoldenPath hg38 (UCSC)WNT5A  -     chr3:55465715-55481398 -  3p14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WNT5A  -     3p14.3   [Description]    (hg19-Feb_2009)
EnsemblWNT5A - 3p14.3 [CytoView hg19]  WNT5A - 3p14.3 [CytoView hg38]
Mapping of homologs : NCBIWNT5A [Mapview hg19]  WNT5A [Mapview hg38]
OMIM164975   180700   
Gene and transcription
Genbank (Entrez)AI634753 AK021503 AK090582 AK290375 AK290869
RefSeq transcript (Entrez)NM_001256105 NM_003392
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WNT5A
Cluster EST : UnigeneHs.643085 [ NCBI ]
CGAP (NCI)Hs.643085
Alternative Splicing GalleryENSG00000114251
Gene ExpressionWNT5A [ NCBI-GEO ]   WNT5A [ EBI - ARRAY_EXPRESS ]   WNT5A [ SEEK ]   WNT5A [ MEM ]
Gene Expression Viewer (FireBrowse)WNT5A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7474
GTEX Portal (Tissue expression)WNT5A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41221   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41221  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41221
Splice isoforms : SwissVarP41221
PhosPhoSitePlusP41221
Domaine pattern : Prosite (Expaxy)WNT1 (PS00246)   
Domains : Interpro (EBI)Wnt    Wnt5a    Wnt_CS   
Domain families : Pfam (Sanger)wnt (PF00110)   
Domain families : Pfam (NCBI)pfam00110   
Domain families : Smart (EMBL)WNT1 (SM00097)  
Conserved Domain (NCBI)WNT5A
DMDM Disease mutations7474
Blocks (Seattle)WNT5A
SuperfamilyP41221
Human Protein AtlasENSG00000114251
Peptide AtlasP41221
HPRD01293
IPIIPI00795811   IPI00013178   IPI00807634   IPI00985138   
Protein Interaction databases
DIP (DOE-UCLA)P41221
IntAct (EBI)P41221
FunCoupENSG00000114251
BioGRIDWNT5A
STRING (EMBL)WNT5A
ZODIACWNT5A
Ontologies - Pathways
QuickGOP41221
Ontology : AmiGOactivation of MAPK activity  establishment of planar polarity  somitogenesis  epithelial to mesenchymal transition  positive regulation of endothelial cell proliferation  heart looping  positive regulation of mesenchymal cell proliferation  lens development in camera-type eye  positive regulation of cytokine secretion involved in immune response  type B pancreatic cell development  planar cell polarity pathway involved in axis elongation  optic cup formation involved in camera-type eye development  transcription factor activity, sequence-specific DNA binding  frizzled binding  frizzled-2 binding  receptor tyrosine kinase-like orphan receptor binding  cytokine activity  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  Wnt signaling pathway, calcium modulating pathway  Wnt signaling pathway, calcium modulating pathway  Wnt signaling pathway, calcium modulating pathway  activation of JUN kinase activity  activation of JUN kinase activity  axon guidance  hindgut morphogenesis  midgut development  male gonad development  anterior/posterior axis specification, embryo  cell surface  response to organic substance  positive regulation of endothelial cell migration  positive regulation of peptidyl-threonine phosphorylation  positive regulation of T cell chemotaxis  positive regulation of neuron projection development  Wnt signaling pathway  Wnt signaling pathway  protein domain specific binding  olfactory bulb interneuron development  neuron differentiation  keratinocyte differentiation  lung development  negative regulation of BMP signaling pathway  clathrin-coated vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  positive regulation of cGMP metabolic process  positive regulation of protein binding  activation of protein kinase B activity  positive regulation of interferon-gamma production  positive regulation of interleukin-6 production  positive regulation of peptidyl-serine phosphorylation  cellular protein localization  non-canonical Wnt signaling pathway  post-anal tail morphogenesis  chemoattraction of serotonergic neuron axon  chemorepulsion of dopaminergic neuron axon  non-canonical Wnt signaling pathway via JNK cascade  negative regulation of fibroblast growth factor receptor signaling pathway  wound healing  embryonic digit morphogenesis  positive regulation of macrophage activation  negative regulation of apoptotic process  transcription regulatory region DNA binding  positive regulation of chemokine biosynthetic process  cell fate commitment  establishment of epithelial cell apical/basal polarity  negative regulation of fat cell differentiation  positive regulation of protein catabolic process  positive regulation of angiogenesis  positive regulation of ossification  positive regulation of endocytosis  positive regulation of meiotic nuclear division  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  receptor agonist activity  negative regulation of melanin biosynthetic process  positive regulation of fibroblast proliferation  paraxial mesoderm formation  notochord morphogenesis  embryonic skeletal system development  genitalia development  negative regulation of axon extension involved in axon guidance  hypophysis morphogenesis  negative regulation of epithelial cell proliferation  positive regulation of interleukin-1 beta secretion  positive regulation of inflammatory response  positive regulation of NF-kappaB transcription factor activity  cartilage development  positive regulation of timing of anagen  negative regulation of synapse assembly  palate development  convergent extension involved in axis elongation  convergent extension involved in organogenesis  uterus development  cervix development  vagina development  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  urinary bladder development  face development  positive regulation of type I interferon-mediated signaling pathway  lateral sprouting involved in mammary gland duct morphogenesis  mesenchymal-epithelial cell signaling  negative regulation of prostatic bud formation  mammary gland branching involved in thelarche  epithelial cell proliferation involved in mammary gland duct elongation  positive regulation of response to cytokine stimulus  regulation of branching involved in mammary gland duct morphogenesis  planar cell polarity pathway involved in gastrula mediolateral intercalation  mesodermal to mesenchymal transition involved in gastrulation  positive regulation of macrophage cytokine production  membrane organization  positive regulation of cartilage development  planar cell polarity pathway involved in outflow tract morphogenesis  planar cell polarity pathway involved in ventricular septum morphogenesis  planar cell polarity pathway involved in cardiac right atrium morphogenesis  planar cell polarity pathway involved in cardiac muscle tissue morphogenesis  planar cell polarity pathway involved in pericardium morphogenesis  extracellular exosome  positive regulation of thymocyte apoptotic process  cellular response to lipopolysaccharide  cellular response to calcium ion  cellular response to retinoic acid  cellular response to interferon-gamma  hematopoietic stem cell proliferation  cellular response to transforming growth factor beta stimulus  negative regulation of mesenchymal cell proliferation  primitive streak formation  positive regulation of protein kinase C signaling  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  positive regulation of canonical Wnt signaling pathway  activation of GTPase activity  melanocyte proliferation  presynapse assembly  postsynapse assembly  positive regulation of protein kinase C activity  chemoattractant activity involved in axon guidance  positive regulation of protein localization to synapse  regulation of cellular protein localization  excitatory synapse assembly  inhibitory synapse assembly  negative regulation of cell proliferation in midbrain  planar cell polarity pathway involved in axon guidance  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation  positive regulation of cell-cell adhesion mediated by cadherin  positive regulation of non-canonical Wnt signaling pathway  positive regulation of interleukin-8 secretion  
Ontology : EGO-EBIactivation of MAPK activity  establishment of planar polarity  somitogenesis  epithelial to mesenchymal transition  positive regulation of endothelial cell proliferation  heart looping  positive regulation of mesenchymal cell proliferation  lens development in camera-type eye  positive regulation of cytokine secretion involved in immune response  type B pancreatic cell development  planar cell polarity pathway involved in axis elongation  optic cup formation involved in camera-type eye development  transcription factor activity, sequence-specific DNA binding  frizzled binding  frizzled-2 binding  receptor tyrosine kinase-like orphan receptor binding  cytokine activity  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  Wnt signaling pathway, calcium modulating pathway  Wnt signaling pathway, calcium modulating pathway  Wnt signaling pathway, calcium modulating pathway  activation of JUN kinase activity  activation of JUN kinase activity  axon guidance  hindgut morphogenesis  midgut development  male gonad development  anterior/posterior axis specification, embryo  cell surface  response to organic substance  positive regulation of endothelial cell migration  positive regulation of peptidyl-threonine phosphorylation  positive regulation of T cell chemotaxis  positive regulation of neuron projection development  Wnt signaling pathway  Wnt signaling pathway  protein domain specific binding  olfactory bulb interneuron development  neuron differentiation  keratinocyte differentiation  lung development  negative regulation of BMP signaling pathway  clathrin-coated vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  positive regulation of cGMP metabolic process  positive regulation of protein binding  activation of protein kinase B activity  positive regulation of interferon-gamma production  positive regulation of interleukin-6 production  positive regulation of peptidyl-serine phosphorylation  cellular protein localization  non-canonical Wnt signaling pathway  post-anal tail morphogenesis  chemoattraction of serotonergic neuron axon  chemorepulsion of dopaminergic neuron axon  non-canonical Wnt signaling pathway via JNK cascade  negative regulation of fibroblast growth factor receptor signaling pathway  wound healing  embryonic digit morphogenesis  positive regulation of macrophage activation  negative regulation of apoptotic process  transcription regulatory region DNA binding  positive regulation of chemokine biosynthetic process  cell fate commitment  establishment of epithelial cell apical/basal polarity  negative regulation of fat cell differentiation  positive regulation of protein catabolic process  positive regulation of angiogenesis  positive regulation of ossification  positive regulation of endocytosis  positive regulation of meiotic nuclear division  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  receptor agonist activity  negative regulation of melanin biosynthetic process  positive regulation of fibroblast proliferation  paraxial mesoderm formation  notochord morphogenesis  embryonic skeletal system development  genitalia development  negative regulation of axon extension involved in axon guidance  hypophysis morphogenesis  negative regulation of epithelial cell proliferation  positive regulation of interleukin-1 beta secretion  positive regulation of inflammatory response  positive regulation of NF-kappaB transcription factor activity  cartilage development  positive regulation of timing of anagen  negative regulation of synapse assembly  palate development  convergent extension involved in axis elongation  convergent extension involved in organogenesis  uterus development  cervix development  vagina development  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  urinary bladder development  face development  positive regulation of type I interferon-mediated signaling pathway  lateral sprouting involved in mammary gland duct morphogenesis  mesenchymal-epithelial cell signaling  negative regulation of prostatic bud formation  mammary gland branching involved in thelarche  epithelial cell proliferation involved in mammary gland duct elongation  positive regulation of response to cytokine stimulus  regulation of branching involved in mammary gland duct morphogenesis  planar cell polarity pathway involved in gastrula mediolateral intercalation  mesodermal to mesenchymal transition involved in gastrulation  positive regulation of macrophage cytokine production  membrane organization  positive regulation of cartilage development  planar cell polarity pathway involved in outflow tract morphogenesis  planar cell polarity pathway involved in ventricular septum morphogenesis  planar cell polarity pathway involved in cardiac right atrium morphogenesis  planar cell polarity pathway involved in cardiac muscle tissue morphogenesis  planar cell polarity pathway involved in pericardium morphogenesis  extracellular exosome  positive regulation of thymocyte apoptotic process  cellular response to lipopolysaccharide  cellular response to calcium ion  cellular response to retinoic acid  cellular response to interferon-gamma  hematopoietic stem cell proliferation  cellular response to transforming growth factor beta stimulus  negative regulation of mesenchymal cell proliferation  primitive streak formation  positive regulation of protein kinase C signaling  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  positive regulation of canonical Wnt signaling pathway  activation of GTPase activity  melanocyte proliferation  presynapse assembly  postsynapse assembly  positive regulation of protein kinase C activity  chemoattractant activity involved in axon guidance  positive regulation of protein localization to synapse  regulation of cellular protein localization  excitatory synapse assembly  inhibitory synapse assembly  negative regulation of cell proliferation in midbrain  planar cell polarity pathway involved in axon guidance  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation  positive regulation of cell-cell adhesion mediated by cadherin  positive regulation of non-canonical Wnt signaling pathway  positive regulation of interleukin-8 secretion  
Pathways : KEGGWnt signaling pathway    Hedgehog signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
REACTOMEP41221 [protein]
REACTOME PathwaysR-HSA-8856828 [pathway]   
NDEx NetworkWNT5A
Atlas of Cancer Signalling NetworkWNT5A
Wikipedia pathwaysWNT5A
Orthology - Evolution
OrthoDB7474
GeneTree (enSembl)ENSG00000114251
Phylogenetic Trees/Animal Genes : TreeFamWNT5A
HOVERGENP41221
HOGENOMP41221
Homologs : HomoloGeneWNT5A
Homology/Alignments : Family Browser (UCSC)WNT5A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWNT5A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WNT5A
dbVarWNT5A
ClinVarWNT5A
1000_GenomesWNT5A 
Exome Variant ServerWNT5A
ExAC (Exome Aggregation Consortium)WNT5A (select the gene name)
Genetic variants : HAPMAP7474
Genomic Variants (DGV)WNT5A [DGVbeta]
DECIPHERWNT5A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWNT5A 
Mutations
ICGC Data PortalWNT5A 
TCGA Data PortalWNT5A 
Broad Tumor PortalWNT5A
OASIS PortalWNT5A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWNT5A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWNT5A
intOGen PortalWNT5A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WNT5A
DgiDB (Drug Gene Interaction Database)WNT5A
DoCM (Curated mutations)WNT5A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WNT5A (select a term)
intoGenWNT5A
NCG5 (London)WNT5A
Cancer3DWNT5A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164975    180700   
Orphanet2781   
MedgenWNT5A
Genetic Testing Registry WNT5A
NextProtP41221 [Medical]
TSGene7474
GENETestsWNT5A
Target ValidationWNT5A
Huge Navigator WNT5A [HugePedia]
snp3D : Map Gene to Disease7474
BioCentury BCIQWNT5A
ClinGenWNT5A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7474
Chemical/Pharm GKB GenePA37385
Clinical trialWNT5A
Miscellaneous
canSAR (ICR)WNT5A (select the gene name)
Probes
Litterature
PubMed283 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWNT5A
EVEXWNT5A
GoPubMedWNT5A
iHOPWNT5A
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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