Related proteins: BACH1 and BACH2 are highly homologous proteins with significant similarity to each other in the bZIP and BTB domains. But the expression pattern and function of the two proteins are different. BACH1 is more ubiquitously expressed whereas BACH2 expression is restricted to mononuclear and neuronal cells. (Shim et al., 2006; Hoshino and Igarashi, 2002; Muto et al., 1998; Oyake et al., 1996).
BACH2 in B-cell differentation: BACH2 is critical for antibody responses including class switch recombination (CSR) and somatic hypermutation (SH) of immunoglobulin genes (Muto et al., 2004). BACH2 and Bcl-6 cooporates to repress Prdm1, and thereby regulating B-cell differentiation through the germinal center (Ochiai et al., 2008).
Neuronal differentiation: BACH2 seems to be involed in neuronal differentiation, by upregulating both cytoplasmic and nuclear p21 protein levels. P21 is a cdk inhibitor known to arrest the cell cycle. In N1E-115 cells regulation of differentiation involves a down regulation of cellular proliferation (Shim et al., 2006).
Immune response: BACH2 is involved in the antiviral response triggered by dsRNA or dsDNA molecular patterns (Hong et al., 2008).
NCBI: 60468 MIM: 605394 HGNC: 14078 Ensembl: ENSG00000112182
dbSNP: 60468 ClinVar: 60468 TCGA: ENSG00000112182 COSMIC: BACH2
Malene Krag Kjeldsen ; Karen Dybkaer ; Jinghua Liu ; Finn Skou Pedersen
BACH2 (BTB and CNC homology 1, basic leucine zipper transcription factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2010-01-01
Online version: http://atlasgeneticsoncology.org/gene/741/js/css/gene-fusions-explorer/