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MYC v-myc myelocytomatosis viral oncogene homolog (avian)

Written2000-08Niels B Atkin
Department of Cancer Research, Mount Vernon Hospital, Northwood, Middlesex, UK

(Note : for Links provided by Atlas : click)

Identity

Other namesMRTL
MYCC
bHLHe39
c-Myc
HGNC (Hugo) MYC
LocusID (NCBI) 4609
Atlas_Id 27
Location 8q24.21
Location_base_pair Starts at 128748315 and ends at 128753680 bp from pter ( according to hg19-Feb_2009)  [Mapping]
 
  c-MYC (8q24) in normal cells: PAC 944B18 (top) and PAC 968N11 (below) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
Fusion genes
(updated 2015)
BCL3 (19q13.32) / MYC (8q24.21)BTG1 (12q21.33) / MYC (8q24.21)CSMD3 (8q23.3) / MYC (8q24.21)
HMGN2P46 (15q21.1) / MYC (8q24.21)IGH (14q32.33) / MYC (8q24.21)IGK (14q32.33) / MYC (8q24.21)
IGL (22q11.22) / MYC (8q24.21)Ig () / MYC (8q24.21)LRMP (12p12.1) / MYC (8q24.21)
MIR142 (17q22) / MYC (8q24.21)MYC (8q24.21) / ARHGEF17 (11q13.4)MYC (8q24.21) / BCL7A (12q24.31)
MYC (8q24.21) / IGH (14q32.33)MYC (8q24.21) / Ig ()MYC (8q24.21) / ZBTB5 (9p13.2)
MYC (8q24.21) / ZCCHC7 (9p13.2)PVT1 (8q24.21) / MYC (8q24.21)RNF213 (17q25.3) / MYC (8q24.21)
TRA (-) / MYC (8q24.21)

DNA/RNA

Transcription alternative splicing; coding sequences: 1318 and 1362 bp for proteins p64 and p67 respectively

Protein

Description 439 amino acids and 48 kDa in the p64; 454 amino acids in the p67 (15 additional amino acids in N-term; contains from N-term to C-term: a transactivation domain,an acidic domain, a nuclear localization signal, a basic domain, an helix-loop-helix motif, and a leucin zipper; DNA binding protein
Expression expressed in almost all proliferating cells in embryonic and adult tissues; in adult tissues, expression correlates with cell proliferation; abnormally high expression is found in a wide variety of human and rodent tumours
Localisation located predominantly in the nucleus
Function
  • The encoded myc oncoproteins are apparently transcription factors known as basic region-helixloop-helix-leucine zipper (b-HLH-Zip) proteins; like other b-HLH-Zip proteins, they modulate the expression of target genes by binding to specific DNA sequences
  • In this case, however, the binding requires dimerization to another b-HLH-Zip protein, namely Max (the latter can also form heterodimers with Mad as well as homodimers with itself). Myc/Max complexes activate transcription and promote cell proliferation and transformation. Mad/Max complexes, however, repress transcription and block myc-mediated cell transformation. All three complexes bind to the same DNA sequence and are competitors.
  • Expression of c-myc is required for proliferation; it can over-ride p53-induced Gl-arrest by inducing an inhibitor of the cyclin kinase inhibitor WAFI(p2l). The latter (located at 6p2l) normally coordinates S and M phases of the cell cycle. If absent, cells with damaged DNA arrest not in GI but in a G2-like state from which they can pass through additional S phases without intervening normal mitoses (the deformed polyploid cells that result may then die by apoptosis). The uncoupling of S and M may contribute to the acquisition of the chromosomal abnormalities manifested by most tumour cells when apoptotic pathways have been circumvented
  • Homology the human myc family also includes N-myc and L-myc, rather specifically implicated in neuroblastoma and small-cell lung carcinoma, respectively, in which amplified copy numbers have been found

    Implicated in

    Note
    Entity Burkitt's lymphoma
    Hybrid/Mutated Gene the gene is activated by translocation next to an immunoglobulin constant gene. Most frequently, it is positioned near the immunoglobulin heavy-chain (IgH) constant region on chromosome 14 but, in some tumours, near the light-chain region chromosome 2 (IgK) or 22 (IgL). It is now known that immunoglobulin joining enzymes may be involved in recombinations associated with a variety of chromosomal translocations in B and T cells
      
    Entity amplification has been described in many types of tumour, including breast, cervical and colon cancers, as well as in squamous cell carcinomas of the head and neck, myeloma, non-Hodgkin's lymphoma, gastric adenocarcinomas and ovarian cancer
    Prognosis C-myc involvement is by no means universally found in these cancers; there may be a correlation with the more advanced stages, suggesting a value as a prognostic indicator (although this has not been demonstrated in some studies for breast, ovarian and cervical cancers)
    Oncogenesis C-myc gene activation (enhanced expression and/or amplification) may result from chromosomal duplication as well as translocation, and from retroviral as well as point mutation. Multiple copies of the gene may be evidenced in homogeneously staining chromosomal regions and in double minutes
      
    Entity Role of c-myc in other conditions
    Disease In adult respiratory distress syndrome the degree of diffuse alveolar damage and consequently the prognosis may be related to the intensity of expression of c-myc in the alveolar cells which, if severe, may contribute to deregulation of cellular proliferation and apoptosis. In endometriosis, c-myc expression is a possibly important regulator of cellular proliferation.
      

    Breakpoints

     

    To be noted

    Although c-myc appears to be active in variety of tumours, it is important to realise that in common with other mechanistic pathways to cancer induction and progression no single genetic event (including c-myc deregulation) will prove to be necessary in the light of the inherent complexity and diversity of cellular pathways leading to neoplasia

    Bibliography

    c-myc and immunoglobulin kappa light chain constant genes are on the 8q+ chromosome of three Burkitt lymphoma lines with t(2;8) translocations.
    Rappold GA, Hameister H, Cremer T, Adolph S, Henglein B, Freese UK, Lenoire GM, Bornkamm GW
    The EMBO journal. 1984 ; 3 (12) : 2951-2955.
    PMID 6441706
     
    Amplification of the c-myc oncogene in a subpopulation of human small cell lung cancer.
    Saksela K, Bergh J, Lehto VP, Nilsson K, Alitalo K
    Cancer research. 1985 ; 45 (4) : 1823-1827.
    PMID 2983887
     
    Myc family genes: a dispersed multi-gene family.
    Depinho RA, Hatton K, Ferrier P, Zimmerman K, Legouy E, Tesfaye A, Collum R, Yancopoulos G, Nisen P, Alt F
    Annals of clinical research. 1986 ; 18 (5-6) : 284-289.
    PMID 3551773
     
    c-myc protooncogene polypeptide expression in endometriosis.
    Schenken RS, Johnson JV, Riehl RM
    American journal of obstetrics and gynecology. 1991 ; 164 (4) : 1031-1036.
    PMID 1707594
     
    The c-myc oncogene in tumor progression.
    Garte SJ
    Critical reviews in oncogenesis. 1993 ; 4 (4) : 435-449.
    PMID 8353142
     
    Chromosomal translocations deregulating c-myc are associated with normal immune responses.
    Roschke V, Kopantzev E, Dertzbaugh M, Rudikoff S
    Oncogene. 1997 ; 14 (25) : 3011-3016.
    PMID 9223664
     
    Repression by the Mad(Mxi1)-Sin3 complex.
    Schreiber-Agus N, DePinho RA
    BioEssays : news and reviews in molecular, cellular and developmental biology. 1998 ; 20 (10) : 808-818.
    PMID 9819568
     
    Amplification of the c-myc oncogene in non-small cell lung cancer.
    Ozkara HA, Ozkara S, Topł▀u S, Criss WE
    Tumori. 1999 ; 85 (6) : 508-511.
    PMID 10774575
     
    MYC oncogenes and human neoplastic disease.
    Nesbit CE, Tersak JM, Prochownik EV
    Oncogene. 1999 ; 18 (19) : 3004-3016.
    PMID 10378696
     
    Proliferation, C-myc, and cyclin D1 expression in diffuse alveolar damage: potential roles in pathogenesis and implications for prognosis.
    Adamson A, Perkins S, Brambilla E, Tripp S, Holden J, Travis W, Guinee D Jr
    Human pathology. 1999 ; 30 (9) : 1050-1057.
    PMID 10492039
     

    Citation

    This paper should be referenced as such :
    Atkin, NB
    MYC (v-myc myelocytomatosis viral oncogene homolog (avian))
    Atlas Genet Cytogenet Oncol Haematol. 2000;4(4):181-182.
    Free journal version : [ pdf ]   [ DOI ]
    On line version : http://AtlasGeneticsOncology.org/Genes/MYCID27.html


    Other Leukemias implicated (Data extracted from papers in the Atlas) [36219+1]
      3q27 rearrangements (BCL6) in non Hodgkin lymphoma;t(3;Var)(q27;Var) in non Hodgkin lymphoma
    Classification of B-cell non-Hodgkin lymphomas (NHL)
    B-cell prolymphocytic leukemia (B-PLL)
    Burkitt's lymphoma (BL)
    Chronic myelogenous leukaemia (CML)
    Diffuse large cell lymphoma
    Hodgkin lymphoma
    t(7;14)(q35;q32.1) TRB/TCL1A;inv(14)(q11q32.1) TRA-TRD/TCL1A;t(14;14)(q11;q32.1) TRA-TRD/TCL1A
    MLL amplification in leukemia
    Multiple myeloma
    Plasma cell leukemia (PCL)
    t(2;8)(p15;q24) BCL11A/MYC
    t(3;6)(q27;p21) PIM1/BCL6
    t(3;8)(q26;q24) PVT1/MECOM
    t(3;8)(q27;q24) BCL6/MYC
    t(3;12)(q27;p12) LRMP/BCL6
    t(5;11)(q33;p13) CAPRIN1/PDGFRB
    t(6;20)(q15;q11.2) BACH2/BCL2L1
    t(7;8)(p12;q24) /MYC
    t(8;9)(q24;p13) ?/MYC
    t(8;12)(q24;p12) LRMP/MYC
    t(8;12)(q24;q22) BTG1/MYC
    t(8;14)(q24;q32) IGH/MYC;t(2;8)(p12;q24) IGK/MYC;t(8;22)(q24;q11) IGL/MYC
    t(8;14)(q24;q11) TRA/MYC
    t(8;17)(q24;q22) ???BCL3/MYC
    t(9;10)(q34;q22) ZMIZ1/ABL1
    t(14;15)(q32;q11) IGH/NBEAP1
    t(3;11)(q13.13;q23) KMT2A/KIAA1524
    T-cell/histiocyte-rich large B cell lymphoma

    Other Solid tumors implicated (Data extracted from papers in the Atlas)
      Bone: Aneurysmal bone cysts
    Nervous system: Astrocytic tumors
    Esophagus: Barrett's esophagus, dysplasia and adenocarcinoma
    Bladder: Urothelial carcinomas
    Bone tumors: an overview
    Breast tumors : an overview
    Bone: Chondrosarcoma
    Colon: Colorectal adenocarcinoma
    Bone: Conventional Osteosarcoma
    Breast: Ductal carcinoma
    Fallopian tube tumors: an overview
    Gastric Tumors: an overview
    Liver: Hepatocellular carcinoma
    Head and Neck: Laryngeal squamous cell carcinoma
    Liver tumors: an overview
    Lung: Non-small cell carcinoma
    Lung: small cell cancer
    Testis: Germ cell tumors
    Head and Neck: Oral squamous cell carcinoma
    Bone: Osteosarcoma
    Ovarian tumours : an overview
    Ovary: Sex cord-stromal tumors
    Ovary: Choriocarcinoma
    Ovary: Epithelial tumors
    Prostate tumors: an overview
    Skin: Melanoma
    Soft tissue tumors: an overview
    Bone: Aneurysmal bone cyst with t(3;17)(q21;p13) CNBP/USP6
    Lung: Translocations in Small Cell Carcinoma
    Uterus Tumours: an Overview
    Eye: Posterior uveal melanoma

    External links

    Nomenclature
    HGNC (Hugo)MYC   7553
    Cards
    AtlasMYCID27
    Entrez_Gene (NCBI)MYC  4609  v-myc avian myelocytomatosis viral oncogene homolog
    GeneCards (Weizmann)MYC
    Ensembl hg19 (Hinxton)ENSG00000136997 [Gene_View]  chr8:128748315-128753680 [Contig_View]  MYC [Vega]
    Ensembl hg38 (Hinxton)ENSG00000136997 [Gene_View]  chr8:128748315-128753680 [Contig_View]  MYC [Vega]
    ICGC DataPortalENSG00000136997
    TCGA cBioPortalMYC
    AceView (NCBI)MYC
    Genatlas (Paris)MYC
    WikiGenes4609
    SOURCE (Princeton)MYC
    Genomic and cartography
    GoldenPath hg19 (UCSC)MYC  -     chr8:128748315-128753680 +  8q24.21   [Description]    (hg19-Feb_2009)
    GoldenPath hg38 (UCSC)MYC  -     8q24.21   [Description]    (hg38-Dec_2013)
    EnsemblMYC - 8q24.21 [CytoView hg19]  MYC - 8q24.21 [CytoView hg38]
    Mapping of homologs : NCBIMYC [Mapview hg19]  MYC [Mapview hg38]
    OMIM113970   190080   
    Gene and transcription
    Genbank (Entrez)AA807892 AK303921 AK312883 BC000141 BC000917
    RefSeq transcript (Entrez)NM_002467
    RefSeq genomic (Entrez)NC_000008 NC_018919 NG_007161 NT_008046 NW_004929340
    Consensus coding sequences : CCDS (NCBI)MYC
    Cluster EST : UnigeneHs.202453 [ NCBI ]
    CGAP (NCI)Hs.202453
    Alternative Splicing : Fast-db (Paris)GSHG0029250
    Alternative Splicing GalleryENSG00000136997
    Gene ExpressionMYC [ NCBI-GEO ]     MYC [ SEEK ]   MYC [ MEM ]
    SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
    BioGPS (Tissue expression)4609
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtP01106 (Uniprot)
    NextProtP01106  [Sequence]  [Exons]  [Medical]  [Publications]
    With graphics : InterProP01106
    Splice isoforms : SwissVarP01106 (Swissvar)
    PhosPhoSitePlusP01106
    Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
    Domains : Interpro (EBI)bHLH_dom    Myc-LZ    Tscrpt_reg_Myc    Tscrpt_reg_Myc_N   
    Domain families : Pfam (Sanger)HLH (PF00010)    Myc-LZ (PF02344)    Myc_N (PF01056)   
    Domain families : Pfam (NCBI)pfam00010    pfam02344    pfam01056   
    Domain families : Smart (EMBL)HLH (SM00353)  
    DMDM Disease mutations4609
    Blocks (Seattle)MYC
    PDB (SRS)1A93    1EE4    1MV0    1NKP    2A93    2OR9   
    PDB (PDBSum)1A93    1EE4    1MV0    1NKP    2A93    2OR9   
    PDB (IMB)1A93    1EE4    1MV0    1NKP    2A93    2OR9   
    PDB (RSDB)1A93    1EE4    1MV0    1NKP    2A93    2OR9   
    Structural Biology KnowledgeBase1A93    1EE4    1MV0    1NKP    2A93    2OR9   
    SCOP (Structural Classification of Proteins)1A93    1EE4    1MV0    1NKP    2A93    2OR9   
    CATH (Classification of proteins structures)1A93    1EE4    1MV0    1NKP    2A93    2OR9   
    Human Protein AtlasENSG00000136997
    Peptide AtlasP01106
    HPRD01818
    IPIIPI00935431   IPI00033016   IPI00816223   IPI00977922   IPI00026900   IPI00425663   IPI00796046   IPI00973947   
    Protein Interaction databases
    DIP (DOE-UCLA)P01106
    IntAct (EBI)P01106
    FunCoupENSG00000136997
    BioGRIDMYC
    IntegromeDBMYC
    STRING (EMBL)MYC
    ZODIACMYC
    Ontologies - Pathways
    QuickGOP01106
    Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  MAPK cascade  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  branching involved in ureteric bud morphogenesis  positive regulation of mesenchymal cell proliferation  DNA binding  DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytosol  energy reserve metabolic process  chromatin remodeling  transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  cellular iron ion homeostasis  cellular response to DNA damage stimulus  cell cycle arrest  transforming growth factor beta receptor signaling pathway  Notch signaling pathway  transcription factor binding  positive regulation of cell proliferation  response to gamma radiation  gene expression  regulation of gene expression  oxygen transport  regulation of telomere maintenance  protein complex binding  negative regulation of stress-activated MAPK cascade  cellular response to UV  cellular response to drug  response to drug  negative regulation of apoptotic process  protein complex  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  fibroblast apoptotic process  negative regulation of monocyte differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  positive regulation of fibroblast proliferation  positive regulation of fibroblast proliferation  negative regulation of fibroblast proliferation  positive regulation of epithelial cell proliferation  chromosome organization  negative regulation of cell division  canonical Wnt signaling pathway  repressing transcription factor binding  response to growth factor  E-box binding  positive regulation of metanephric cap mesenchymal cell proliferation  positive regulation of DNA biosynthetic process  positive regulation of response to DNA damage stimulus  
    Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  MAPK cascade  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  branching involved in ureteric bud morphogenesis  positive regulation of mesenchymal cell proliferation  DNA binding  DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytosol  energy reserve metabolic process  chromatin remodeling  transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  cellular iron ion homeostasis  cellular response to DNA damage stimulus  cell cycle arrest  transforming growth factor beta receptor signaling pathway  Notch signaling pathway  transcription factor binding  positive regulation of cell proliferation  response to gamma radiation  gene expression  regulation of gene expression  oxygen transport  regulation of telomere maintenance  protein complex binding  negative regulation of stress-activated MAPK cascade  cellular response to UV  cellular response to drug  response to drug  negative regulation of apoptotic process  protein complex  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  fibroblast apoptotic process  negative regulation of monocyte differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  positive regulation of fibroblast proliferation  positive regulation of fibroblast proliferation  negative regulation of fibroblast proliferation  positive regulation of epithelial cell proliferation  chromosome organization  negative regulation of cell division  canonical Wnt signaling pathway  repressing transcription factor binding  response to growth factor  E-box binding  positive regulation of metanephric cap mesenchymal cell proliferation  positive regulation of DNA biosynthetic process  positive regulation of response to DNA damage stimulus  
    Pathways : BIOCARTACTCF: First Multivalent Nuclear Factor [Genes]    MAPKinase Signaling Pathway [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    Overview of telomerase protein component gene hTert Transcriptional Regulation [Genes]    Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy [Genes]    WNT Signaling Pathway [Genes]    Cadmium induces DNA synthesis and proliferation in macrophages [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    Telomeres, Telomerase, Cellular Aging, and Immortality [Genes]    Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    p38 MAPK Signaling Pathway [Genes]    Tumor Suppressor Arf Inhibits Ribosomal Biogenesis [Genes]   
    Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Cell cycle    PI3K-Akt signaling pathway    Wnt signaling pathway    TGF-beta signaling pathway    Hippo signaling pathway    Jak-STAT signaling pathway    Thyroid hormone signaling pathway    Hepatitis B    HTLV-I infection    Epstein-Barr virus infection    Pathways in cancer    Transcriptional misregulation in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Colorectal cancer    Endometrial cancer    Thyroid cancer    Bladder cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Small cell lung cancer   
    REACTOMEP01106 [protein]
    REACTOME PathwaysR-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription [pathway]
    REACTOME PathwaysR-HSA-5687128 MAPK6/MAPK4 signaling [pathway]
    REACTOME PathwaysR-HSA-69202 Cyclin E associated events during G1/S transition [pathway]
    REACTOME PathwaysR-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry [pathway]
    REACTOME PathwaysR-HSA-4411364 binding of TCF/LEF:CTNNB1 to target gene promoters [pathway]
    REACTOME PathwaysR-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants [pathway]
    REACTOME PathwaysR-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants [pathway]
    REACTOME PathwaysR-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription [pathway]
    Protein Interaction DatabaseMYC
    Atlas of Cancer Signalling NetworkMYC
    Wikipedia pathwaysMYC
    Orthology - Evolution
    OrthoDB4609
    GeneTree (enSembl)ENSG00000136997
    Phylogenetic Trees/Animal Genes : TreeFamMYC
    Gene fusions - Rearrangements
    Fusion : MitelmanBCL3/MYC [19q13.32/8q24.21]  [t(8;19)(q24;q13)]  
    Fusion : MitelmanBTG1/MYC [12q21.33/8q24.21]  [t(8;12)(q24;q22)]  
    Fusion : MitelmanCSMD3/MYC [8q23.3/8q24.21]  [t(8;8)(q23;q24)]  
    Fusion : MitelmanHMGN2P46/MYC [15q21.1/8q24.21]  [t(8;15)(q24;q21)]  
    Fusion : MitelmanIGH/MYC [14q32.33/8q24.21]  [t(6;8;14)(p21;q24;q32)]  [t(8;14)(q24;q32)]  
    [t(8;14;18)(q24;q32;q21)]  
    Fusion : MitelmanIGK/MYC [14q32.33/8q24.21]  [t(2;8)(p11;q24)]  
    Fusion : MitelmanIGL/MYC [22q11.22/8q24.21]  [t(8;22)(q24;q11)]  
    Fusion : MitelmanLRMP/MYC [12p12.1/8q24.21]  [t(8;12)(q24;p12)]  
    Fusion : MitelmanMYC/ARHGEF17 [8q24.21/11q13.4]  [t(8;11)(q24;q13)]  
    Fusion : MitelmanMYC/BCL7A [8q24.21/12q24.31]  [t(8;14;12)(q24;q32;q24)]  
    Fusion : MitelmanMYC/ZBTB5 [8q24.21/9p13.2]  [t(8;9)(q24;p13)]  
    Fusion : MitelmanMYC/ZCCHC7 [8q24.21/9p13.2]  [t(8;9)(q24;p13)]  
    Fusion : MitelmanPVT1/MYC [8q24.21/8q24.21]  [t(8;8)(q24;q24)]  
    Fusion : MitelmanRNF213/MYC [17q25.3/8q24.21]  [t(8;17)(q24;q25)]  
    Fusion : MitelmanTRA/MYC [-/8q24.21]  [t(8;14)(q24;q11)]  
    Fusion : TICdbIg [MYC]  -  8q24.21 []
    Fusion : TICdbMIR142 [17q22]  -  MYC [8q24.21]
    Fusion : TICdbMYC [8q24.21]  -  Ig []
    Fusion Cancer (Beijing)ENSG00000211894 [MYC]  -  8q24.21 [FUSC000227]  [FUSC000227]
    Polymorphisms : SNP, variants
    NCBI Variation ViewerMYC [hg38]
    dbSNP Single Nucleotide Polymorphism (NCBI)MYC
    dbVarMYC
    ClinVarMYC
    1000_GenomesMYC 
    Exome Variant ServerMYC
    SNP (GeneSNP Utah)MYC
    SNP : HGBaseMYC
    Genetic variants : HAPMAPMYC
    Genomic Variants (DGV)MYC [DGVbeta]
    Mutations
    ICGC Data PortalMYC 
    TCGA Data PortalMYC 
    Broad Tumor PortalMYC
    OASIS PortalMYC
    TCGA Copy Number PortalMYC
    Cancer Gene: CensusMYC 
    Somatic Mutations in Cancer : COSMICMYC 
    intOGen PortalMYC
    LOVD (Leiden Open Variation Database)Whole genome datasets
    LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
    BioMutasearch MYC
    DgiDB (Drug Gene Interaction Database)MYC
    DoCM (Curated mutations)MYC (select the gene name)
    CIViC (Clinical Interpretations of Variants in Cancer)MYC (select a term)
    Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
    Diseases
    DECIPHER (Syndromes)8:128748315-128753680
    CONAN: Copy Number AnalysisMYC 
    Mutations and Diseases : HGMDMYC
    OMIM113970    190080   
    MedgenMYC
    NextProtP01106 [Medical]
    TSGene4609
    GENETestsMYC
    Huge Navigator MYC [HugePedia]  MYC [HugeCancerGEM]
    snp3D : Map Gene to Disease4609
    BioCentury BCIQMYC
    General knowledge
    Homologs : HomoloGeneMYC
    Homology/Alignments : Family Browser (UCSC)MYC
    Chemical/Protein Interactions : CTD4609
    Chemical/Pharm GKB GenePA31353
    Drug Sensitivity MYC
    Clinical trialMYC
    Other databases
    Probes
    Probec-MYC (8q24) in normal cells (Bari)
    Litterature
    PubMed499 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    CoreMineMYC
    GoPubMedMYC
    iHOPMYC
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

    Search in all EBI   NCBI

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    indexed on : Wed Feb 10 12:52:49 CET 2016

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