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Entity | Inclusion body myopathy associated with Paget disease of the bone and frontotemporal dementia (IBMPFD) |
Note | This rare proteinopathy, affecting mainly muscle, brain and bone, is associated with mutations in the p97/VCP gene (Watts et al., 2004). Muscle biopsies in IBMPFD patients have revealed the presence of rimmed vacuoles, cytoplasmic inclusion bodies and p97/VCP aggregates in scattered muscle fibers (Watts et al., 2004). IBMPFD neuropathologic changes are characterized by ubiquitin-positive neuronal intranuclear inclusions and dystrophic neurites mainly abundant in the neocortex (Forman et al., 2006). There are 26 mutations in p97/VCP identified so far in IBMPFD patients and these mutations are primarily in the N-terminal domain involved in ubiquitin binding and protein-protein interactions (Nalbandian et al., 2012). |
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Entity | Amyotrophic lateral sclerosis (ALS) |
Note | Mutations in p97/VCP gene have been recently found also in familial cases of amyotrophic lateral sclerosis (ALS). A study using whole exome sequencing identified a pathogenic p97/VCP variant in an autosomal dominant Italian family with an ALS phenotype, and subsequently found that p97/VCP mutations were present in ~1-2% of our large cohort of familial ALS cases from unrelated families (Johnson et al., 2010). Whereas, no mutations were identified indicating that p97/VCP mutations do not have main contribution of classic ALS among Australian cases and Italian population (Tiloca et al., 2012; Williams et al., 2012). The p97/VCP expression was found to be increased in the skin of ALS patients (Ishikawa et al., 2012). |
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Entity | Hepatocellular carcinoma |
Note | miRNA-129-5p downregulates p97/VCP expression and this regulation plays an important role in the progression of hepatacellular carcinoma (Liu et al., 2012). p97/VCP expression was found to be prognostic significant for disease-free and overall survival of patients with hepatocellular carcinoma (Yamamoto et al., 2003). |
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Entity | Colorectal carcinoma |
Note | There is one study with 129 patients showing an association between high level-expression of p97/VCP with colorectal cancer prognosis (Yamamoto et al., 2004d). |
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Entity | Esophageal carcinoma |
Note | The prognostic significance of p97/VCP expression in 156 esophageal squamous cell carcinoma (ESCC) patients has been revealed by Yamamoto et al. in 2004 (Yamamoto et al., 2004b). |
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Entity | Prostate cancer |
Note | Elevated expression of p97/VCP has been associated with poor prognosis of prostate cancer with the study performed by analyzing p97/VCP expression in 136 patients (Tsujimoto et al., 2004). |
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Entity | Breast cancer |
Note | The p97/VCP gene is underexpressed in patients who died of breast cancer within 5 years of surgery compared to patients who survived disease-free for more than 5 years (Asaka et al., 2006). Increased serum p97/VCP levels were observed in clinically significant proportions of breast cancer patients (Laguë et al., 2012). |
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Entity | Pancreatic cancer |
Note | A global genomic analysis of pancreatic cancer has confirmed p97/VCP overexpression and association with tumor metastasis by Serial Analysis of Gene Expression (SAGE). Other studies have indicated the generalized role of UPS in regulating the metastatic potential of pancreatic cancer (Jones et al., 2008). Increased expression of p97/VCP is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma (Yamamoto et al., 2004a). Moreover, elevated serum p97/VCP levels were detected in clinically significant proportions of patients with pancreatic cancer (8 of 12) (Laguë et al., 2012). p97/VCP was also found to be a useful marker in detecting malignant behavior of pancreatic endocrine neoplasms (Yamamoto et al., 2004f). |
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Entity | Gingival squamous cell carcinoma |
Note | It has been shown that the expression level of p97/VCP may be used as prognostic marker for gingival squamous cell carcinoma (GSCC) (Yamamoto et al., 2004e). Moreover, the expression patterns of PBX2, a strong prognostic factor in GSCC, and p97/VCP proteins were evaluated in 66 subjects with GSCC who underwent curative surgery, and high PBX2 expression was associated with high p97/VCP expression (Qiu et al., 2012). |
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Entity | Thyroid carcinoma |
Note | A study examining the p97/VCP expression in 332 patients who underwent operation for differentiated thyroid carcinoma showed that increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer (Yamamoto et al., 2005). |
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Entity | Non-small cell lung carcinoma |
Note | Elevated p97/VCP expression is correlated with the progression and clinical prognosis of non-small cell lung carcinoma (NSCLC) (Yamamoto et al., 2004c). Moreover, p97/VCP inhibition suppressed proliferation, induced G0/G1-phase cell cycle arrest of NSCLCs and migration in H1299 cells and reduced NSCLC tumor growth in both in vitro and xenograft murine (athymic-nude) models after EerI treatment (Valle CW et al., 2011). |
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Entity | Gastric cancer |
Note | Expression level of p97/VCP was found to be associated with prognosis and progression of gastric cancer (Yamamoto et al., 2003). |
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Entity | Leukemia |
Note | Monocytic differentiation and G0/G1 growth arrest in human U937 leukemia cells is accompanied by an increase in VCP/p97 expression and a distinct subcellular distribution to be reverted during retrodifferentiation (Bertram et al., 2008). Furthermore, high p97/VCP expression has been shown to be associated with poor prednisone response in childhood acute lymphoblastic leukaemia patients (Lauten et al., 2006). |
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Entity | Osteosarcoma |
Note | A study on osteosarcoma indicates the function of p97/VCP as a regulator of NFkB mediated tumor metastasis (Asai et al., 2002). |
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Entity | Neurodegeneration |
Note | Excessive accumulation of misfolded proteins may inactivate p97/VCP in several neurodegenerative disorders, eventually leading to the neurodegenerations (Hirabayashi et al., 2001; Hsueh, 2012). |
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Entity | Werner syndrome |
Note | It has been proposed that a novel role for p97/VCP in the DNA damage response pathway via modulating the availabilty of Werner protein, mutations of which causes Werner syndrome, a genetic disorder characterized by premature onset of aging symptoms (Partridge et al., 2003; Indig et al., 2004). |
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Entity | Machado-joseph disease |
Note | Expansion of a polyglutamine tract in ataxin-3 (AT3), a deubiquitylating enzyme, results in spinocerebellar ataxia type 3/Machado-Joseph disease. AT3 interacts with p97/VCP and regulates flow through the ERAD pathway by modulating VCP-dependent extraction of proteins from the ER (Zhong and Pittman, 2006). Furthermore, p97/VCP was shown to be an activator specifically of wild-type ataxin-3, exhibiting no effect on expanded ataxin-3 (Laco et al., 2012). |
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Entity | Hepatitis |
Note | Hepatitis B virus X protein (HBx protein) transactivates NF-kB, which is important in the pathogenesis of HBV-related diseases. It has been shown that Hbx interacts with VCP, and enhances the VCP-mediated activation of NF-kB (Jiao et al., 2011). |
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Entity | Chronic obstructive pulmonary disease and emphysema |
Note | There is a study correlating the higher expression of valosin-containing protein (VCP) retrograde translocation complex (VCP-Rma1-gp78) with severity of emphysema in chronic obstructive pulmonary disease (COPD) lung tissues and over-expression of inflammatory, ER stress and apoptotic mediators like NFκB, GADD-153/CHOP, and p-eIF2α (Min et al., 2011). |
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Entity | Cholesterol |
Note | Insig-1, a negative regulator of cholesterol synthesis is rapidly degraded by proteasomes when cells lack of cholesterol, and its degradation is inhibited when sterols accumulate. p97/VCP was shown to recruit proteasomes to Insig-1 before extraction from membrane (Ikeda et al., 2009). It is also known that ubiqitinated 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is recognized by the ATPase VCP/p97, which mediates extraction and delivery of reductase from ER membranes to cytosolic 26 S proteasomes for degradation (Hartman et al., 2010). |
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Entity | Antiviral immunity |
Note | p97/VCP is implicated as a host factor in antiviral immunity, where depletion or catalytic inhibition of p97/VCP prevents capsid degradation and reduces neutralization (Hauler et al., 2012). |
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The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. |
Acs K, Luijsterburg MS, Ackermann L, Salomons FA, Hoppe T, Dantuma NP. |
Nat Struct Mol Biol. 2011 Nov 27;18(12):1345-50. doi: 10.1038/nsmb.2188. |
PMID 22120668 |
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VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line. |
Asai T, Tomita Y, Nakatsuka S, Hoshida Y, Myoui A, Yoshikawa H, Aozasa K. |
Jpn J Cancer Res. 2002 Mar;93(3):296-304. |
PMID 11927012 |
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Genetic prognostic index influences patient outcome for node-positive breast cancer. |
Asaka S, Fujimoto T, Akaishi J, Ogawa K, Onda M. |
Surg Today. 2006;36(9):793-801. |
PMID 16937283 |
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Different p97/VCP complexes function in retrotranslocation step of mammalian ER-associated degradation (ERAD). |
Ballar P, Pabuccuoglu A, Kose FA. |
Int J Biochem Cell Biol. 2011 Apr;43(4):613-21. doi: 10.1016/j.biocel.2010.12.021. Epub 2010 Dec 31. |
PMID 21199683 |
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Cdc48-Ufd1-Npl4: stuck in the middle with Ub. |
Bays NW, Hampton RY. |
Curr Biol. 2002 May 14;12(10):R366-71. (REVIEW) |
PMID 12015140 |
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The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97. |
Bertram C, von Neuhoff N, Skawran B, Steinemann D, Schlegelberger B, Hass R. |
BMC Cell Biol. 2008 Feb 15;9:12. doi: 10.1186/1471-2121-9-12. |
PMID 18279508 |
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Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substrates. |
Braun S, Matuschewski K, Rape M, Thoms S, Jentsch S. |
EMBO J. 2002 Feb 15;21(4):615-21. |
PMID 11847109 |
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The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis. |
Cao K, Nakajima R, Meyer HH, Zheng Y. |
Cell. 2003 Oct 31;115(3):355-67. |
PMID 14636562 |
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DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage. |
Davis EJ, Lachaud C, Appleton P, Macartney TJ, Nathke I, Rouse J. |
Nat Struct Mol Biol. 2012 Nov;19(11):1093-100. doi: 10.1038/nsmb.2394. Epub 2012 Oct 7. |
PMID 23042607 |
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The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication. |
Deichsel A, Mouysset J, Hoppe T. |
Cell Cycle. 2009 Jan 15;8(2):185-90. Epub 2009 Jan 6. (REVIEW) |
PMID 19158489 |
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CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. |
Franz A, Orth M, Pirson PA, Sonneville R, Blow JJ, Gartner A, Stemmann O, Hoppe T. |
Mol Cell. 2011 Oct 7;44(1):85-96. doi: 10.1016/j.molcel.2011.08.028. |
PMID 21981920 |
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Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets. |
Hartman IZ, Liu P, Zehmer JK, Luby-Phelps K, Jo Y, Anderson RG, DeBose-Boyd RA. |
J Biol Chem. 2010 Jun 18;285(25):19288-98. doi: 10.1074/jbc.M110.134213. Epub 2010 Apr 20. |
PMID 20406816 |
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AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization. |
Hauler F, Mallery DL, McEwan WA, Bidgood SR, James LC. |
Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19733-8. doi: 10.1073/pnas.1210659109. Epub 2012 Oct 22. |
PMID 23091005 |
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A stress-responsive system for mitochondrial protein degradation. |
Heo JM, Livnat-Levanon N, Taylor EB, Jones KT, Dephoure N, Ring J, Xie J, Brodsky JL, Madeo F, Gygi SP, Ashrafi K, Glickman MH, Rutter J. |
Mol Cell. 2010 Nov 12;40(3):465-80. doi: 10.1016/j.molcel.2010.10.021. |
PMID 21070972 |
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Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. |
Hetzer M, Meyer HH, Walther TC, Bilbao-Cortes D, Warren G, Mattaj IW. |
Nat Cell Biol. 2001 Dec;3(12):1086-91. |
PMID 11781570 |
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VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration. |
Hirabayashi M, Inoue K, Tanaka K, Nakadate K, Ohsawa Y, Kamei Y, Popiel AH, Sinohara A, Iwamatsu A, Kimura Y, Uchiyama Y, Hori S, Kakizuka A. |
Cell Death Differ. 2001 Oct;8(10):977-84. |
PMID 11598795 |
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Mapping the valosin-containing protein (VCP) gene on human chromosome 9 and mouse chromosome 4, and a likely pseudogene on the mouse X chromosome. |
Hoyle J, Tan KH, Fisher EM. |
Mamm Genome. 1997 Oct;8(10):778-80. |
PMID 9321476 |
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From neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formation. |
Hsueh YP. |
J Biomed Sci. 2012 Mar 26;19:33. doi: 10.1186/1423-0127-19-33. (REVIEW) |
PMID 22449146 |
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Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes. |
Ikeda Y, Demartino GN, Brown MS, Lee JN, Goldstein JL, Ye J. |
J Biol Chem. 2009 Dec 11;284(50):34889-900. doi: 10.1074/jbc.M109.044875. Epub 2009 Oct 8. |
PMID 19815544 |
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Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion. |
Indig FE, Partridge JJ, von Kobbe C, Aladjem MI, Latterich M, Bohr VA. |
J Struct Biol. 2004 Apr-May;146(1-2):251-9. |
PMID 15037256 |
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Increased expression of valosin-containing protein in the skin of patients with amyotrophic lateral sclerosis. |
Ishikawa H, Yasui K, Oketa Y, Suzuki M, Ono S. |
J Clin Neurosci. 2012 Apr;19(4):522-6. doi: 10.1016/j.jocn.2011.05.044. Epub 2012 Feb 8. |
PMID 22321369 |
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Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. |
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Nat Cell Biol. 2002 Feb;4(2):134-9. |
PMID 11813000 |
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Hepatitis B virus X protein enhances activation of nuclear factor κB through interaction with valosin-containing protein. |
Jiao BY, Lin WS, She FF, Chen WN, Lin X. |
Arch Virol. 2011 Nov;156(11):2015-21. doi: 10.1007/s00705-011-1099-4. Epub 2011 Sep 15. |
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Exome sequencing reveals VCP mutations as a cause of familial ALS. |
Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandez DG, Arepalli S, Chong S, Schymick JC, Rothstein J, Landi F, Wang YD, Calvo A, Mora G, Sabatelli M, Monsurro MR, Battistini S, Salvi F, Spataro R, Sola P, Borghero G; ITALSGEN Consortium, Galassi G, Scholz SW, Taylor JP, Restagno G, Chio A, Traynor BJ. |
Neuron. 2010 Dec 9;68(5):857-64. doi: 10.1016/j.neuron.2010.11.036. |
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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. |
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Science. 2008 Sep 26;321(5897):1801-6. doi: 10.1126/science.1164368. Epub 2008 Sep 4. |
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Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy. |
Ju JS, Weihl CC. |
Hum Mol Genet. 2010 Apr 15;19(R1):R38-45. doi: 10.1093/hmg/ddq157. Epub 2010 Apr 21. (REVIEW) |
PMID 20410287 |
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Use of a cDNA clone to identify a supposed precursor protein containing valosin. |
Koller KJ, Brownstein MJ. |
Nature. 1987 Feb 5-11;325(6104):542-5. |
PMID 3468358 |
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Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3. |
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PLoS One. 2012;7(9):e43563. doi: 10.1371/journal.pone.0043563. Epub 2012 Sep 6. |
PMID 22970133 |
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Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human cancers. |
Lague MN, Romieu-Mourez R, Bonneil E, Boyer A, Pouletty N, Mes-Masson AM, Thibault P, Nadeau ME, Boerboom D. |
PLoS One. 2012;7(8):e42470. doi: 10.1371/journal.pone.0042470. Epub 2012 Aug 1. |
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Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes. |
Latterich M, Frohlich KU, Schekman R. |
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Unsupervised proteome analysis of human leukaemia cells identifies the Valosin-containing protein as a putative marker for glucocorticoid resistance. |
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Leukemia. 2006 May;20(5):820-6. |
PMID 16541142 |
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Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasome. |
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Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15809-14. Epub 2005 Oct 25. |
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Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14296-301. Epub 2005 Sep 26. |
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VCP/p97, down-regulated by microRNA-129-5p, could regulate the progression of hepatocellular carcinoma. |
Liu Y, Hei Y, Shu Q, Dong J, Gao Y, Fu H, Zheng X, Yang G. |
PLoS One. 2012;7(4):e35800. doi: 10.1371/journal.pone.0035800. Epub 2012 Apr 20. |
PMID 22536440 |
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Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. |
Meyer H, Bug M, Bremer S. |
Nat Cell Biol. 2012 Feb 2;14(2):117-23. doi: 10.1038/ncb2407. (REVIEW) |
PMID 22298039 |
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Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema. |
Min T, Bodas M, Mazur S, Vij N. |
J Mol Med (Berl). 2011 Jun;89(6):577-93. doi: 10.1007/s00109-011-0732-8. Epub 2011 Feb 12. |
PMID 21318260 |
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Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. |
Mouysset J, Deichsel A, Moser S, Hoege C, Hyman AA, Gartner A, Hoppe T. |
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12879-84. doi: 10.1073/pnas.0805944105. Epub 2008 Aug 26. |
PMID 18728180 |
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The homozygote VCP(R155H/R155H) mouse model exhibits accelerated human VCP-associated disease pathology. |
Nalbandian A, Llewellyn KJ, Kitazawa M, Yin HZ, Badadani M, Khanlou N, Edwards R, Nguyen C, Mukherjee J, Mozaffar T, Watts G, Weiss J, Kimonis VE. |
PLoS One. 2012;7(9):e46308. doi: 10.1371/journal.pone.0046308. Epub 2012 Sep 28. |
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DNA damage modulates nucleolar interaction of the Werner protein with the AAA ATPase p97/VCP. |
Partridge JJ, Lopreiato JO Jr, Latterich M, Indig FE. |
Mol Biol Cell. 2003 Oct;14(10):4221-9. Epub 2003 Aug 22. |
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Structural insights into the p97-Ufd1-Npl4 complex. |
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Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):467-72. Epub 2007 Jan 3. |
PMID 17202270 |
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Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma. |
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J Zhejiang Univ Sci B. 2012 Mar;13(3):168-75. doi: 10.1631/jzus.B1100077. |
PMID 22374608 |
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AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation. |
Rabinovich E, Kerem A, Frohlich KU, Diamant N, Bar-Nun S. |
Mol Cell Biol. 2002 Jan;22(2):626-34. |
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p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response. |
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Cell Cycle. 2012 Mar 15;11(6):1062-9. doi: 10.4161/cc.11.6.19446. Epub 2012 Mar 15. |
PMID 22391235 |
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Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations. |
Ritz D, Vuk M, Kirchner P, Bug M, Schutz S, Hayer A, Bremer S, Lusk C, Baloh RH, Lee H, Glatter T, Gstaiger M, Aebersold R, Weihl CC, Meyer H. |
Nat Cell Biol. 2011 Aug 7;13(9):1116-23. doi: 10.1038/ncb2301. |
PMID 21822278 |
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Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. |
Rouiller I, DeLaBarre B, May AP, Weis WI, Brunger AT, Milligan RA, Wilson-Kubalek EM. |
Nat Struct Biol. 2002 Dec;9(12):950-7. |
PMID 12434150 |
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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. |
Tanaka A, Cleland MM, Xu S, Narendra DP, Suen DF, Karbowski M, Youle RJ. |
J Cell Biol. 2010 Dec 27;191(7):1367-80. doi: 10.1083/jcb.201007013. Epub 2010 Dec 20. |
PMID 21173115 |
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Mutational analysis of VCP gene in familial amyotrophic lateral sclerosis. |
Tiloca C, Ratti A, Pensato V, Castucci A, Soraru G, Del Bo R, Corrado L, Cereda C, D'Ascenzo C, Comi GP, Mazzini L, Castellotti B, Ticozzi N, Gellera C, Silani V; SLAGEN Consortium. |
Neurobiol Aging. 2012 Mar;33(3):630.e1-2. doi: 10.1016/j.neurobiolaging.2011.10.025. Epub 2011 Dec 3. |
PMID 22137929 |
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VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. |
Tresse E, Salomons FA, Vesa J, Bott LC, Kimonis V, Yao TP, Dantuma NP, Taylor JP. |
Autophagy. 2010 Feb;6(2):217-27. Epub 2010 Feb 22. |
PMID 20104022 |
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Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer. |
Tsujimoto Y, Tomita Y, Hoshida Y, Kono T, Oka T, Yamamoto S, Nonomura N, Okuyama A, Aozasa K. |
Clin Cancer Res. 2004 May 1;10(9):3007-12. |
PMID 15131036 |
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p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis. |
Uchiyama K, Totsukawa G, Puhka M, Kaneko Y, Jokitalo E, Dreveny I, Beuron F, Zhang X, Freemont P, Kondo H. |
Dev Cell. 2006 Dec;11(6):803-16. |
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Critical role of VCP/p97 in the pathogenesis and progression of non-small cell lung carcinoma. |
Valle CW, Min T, Bodas M, Mazur S, Begum S, Tang D, Vij N. |
PLoS One. 2011;6(12):e29073. doi: 10.1371/journal.pone.0029073. Epub 2011 Dec 22. |
PMID 22216170 |
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Molecular perspectives on p97-VCP: progress in understanding its structure and diverse biological functions. |
Wang Q, Song C, Li CC. |
J Struct Biol. 2004 Apr-May;146(1-2):44-57. (REVIEW) |
PMID 15037236 |
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Mutation analysis of VCP in familial and sporadic amyotrophic lateral sclerosis. |
Williams KL, Solski JA, Nicholson GA, Blair IP. |
Neurobiol Aging. 2012 Jul;33(7):1488.e15-6. doi: 10.1016/j.neurobiolaging.2011.11.022. Epub 2011 Dec 22. |
PMID 22196955 |
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p97, a protein coping with multiple identities. |
Woodman PG. |
J Cell Sci. 2003 Nov 1;116(Pt 21):4283-90. |
PMID 14514884 |
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The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover. |
Xu S, Peng G, Wang Y, Fang S, Karbowski M. |
Mol Biol Cell. 2011 Feb 1;22(3):291-300. doi: 10.1091/mbc.E10-09-0748. Epub 2010 Nov 30. |
PMID 21118995 |
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Increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer. |
Yamamoto S, Tomita Y, Uruno T, Hoshida Y, Qiu Y, Iizuka N, Nakamichi I, Miyauchi A, Aozasa K. |
Ann Surg Oncol. 2005 Nov;12(11):925-34. Epub 2005 Sep 29. |
PMID 16189643 |
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Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. |
Ye Y, Meyer HH, Rapoport TA. |
J Cell Biol. 2003 Jul 7;162(1):71-84. |
PMID 12847084 |
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Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. |
Zhong X, Pittman RN. |
Hum Mol Genet. 2006 Aug 15;15(16):2409-20. Epub 2006 Jul 5. |
PMID 16822850 |
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AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. |
Zhong X, Shen Y, Ballar P, Apostolou A, Agami R, Fang S. |
J Biol Chem. 2004 Oct 29;279(44):45676-84. Epub 2004 Aug 24. |
PMID 15331598 |
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