MAPK14 (mitogen-activated protein kinase 14)

2010-12-01 Almudena Porras , Carmen Guerrero Affiliation

Departamento de Bioquimica y Biologia Molecular II, Facultad de Farmacia, UCM, Ciudad Universitaria, 28040 Madrid, Spain (AP); Centro de Investigacion del Cancer, IBMCC, Universidad de Salamanca-CSIC, 37007 Salamanca, Spain (CG)

Identity

HGNC

MAPK14

LOCATION

6p21.31

IMAGE

LEGEND

Schematic representation of human chromosome 6 indicating the position of MAPK14 locus (p21.31) (red bar).

LOCUSID

1432

ALIAS

CSBP,CSBP1,CSBP2,CSPB1,EXIP,Mxi2,PRKM14,PRKM15,RK,SAPK2A,p38,p38ALPHA

FUSION GENES

Show Gene Fusions

DNA/RNA

MAPK14 gene locus. Representation of the MAPK14 gene organization indicating the position of the exons (coding region) and untranslated regions.

Description

The gene spans a region of 83.53 kb and the coding part is divided into 41 different exons. Larger transcripts contain 12 or 13 exons. (GATExplorer).

Transcription

9 types of transcripts have been described, although only 5 are protein coding transcripts. The larger 4319-nucleotide transcript encodes a protein of 360 amino acid residues. The first and last exons are partially untranslated.

Pseudogene

None described so far.

Proteins

MAPK14 protein domains. Schematic representation of MAPK14 protein indicating the position of its functional domains. 30-54: protein kinase ATP signature, ATP-binding region; 59-162: MAPK signature; 24-308: protein kinase domain.

Description

MAPK14 is a Ser/Thr kinase composed of 90 to 360 residues depending on the transcript variant.

Crystal structure of MAPK14 at 2.3 A resolution. From PDB (access number: 1WFC).

Expression

p38alpha MAPK is ubiquitously expressed, being the p38 most abundant isoform.

Localisation

p38alpha is mainly present in the cytosol, but it can translocate to the nucleus. In addition, it can be localized in the mitochondria or in other subcellular compartments.

Function

p38alpha is mainly activated by various environmental stresses and proinflammatory cytokines, but many other extracellular signals, including growth factors, also lead to p38alpha activation. The canonical activation requires its phosphorylation in threonine and tyrosine residues by dual-specificity MAP kinase kinases (MKKs), MKK3, MKK6 and MKK4. Substrates of this kinase include transcription factors, such as ATF1, ATF2, ATF6, p53, MEF2 or C/EBPbeta and protein kinases, such as MAPKAP-K2 and MAPKAP-K3 (also known as MK-2 and MK-3), MSK-1, MNK-1/MNK-2 and other proteins. p38alpha MAPK is essential for embryonic development and it regulates different cellular functions such as proliferation, differentiation, cell death, adhesion, migration, as well as the response to stress and many metabolic pathways, among others. It does so through regulation of transcription, mRNA stability, chromatin remodelling, protein synthesis, etc. Concerning cell death, although p38alpha plays an important role as a pro-apoptotic signal, it can play a dual role, acting as either a mediator of cell survival or of cell death, depending on the cell type and the stimuli. Related with its function as a negative regulator of proliferation and a mediator of apoptosis, p38alpha acts as a tumor suppressor in the initial stages of a tumorigenic process, while at later stages it can promote metastasis.

Signaling through p38alphaMAPK. Signaling through MAPK14 cascade and its role in the regulation of cellular functions. MAPK14 is involved in signaling pathways triggered by a variety of stimuli such as growth factors, oxidative stress, UV, cytokines and DNA damage. Depending on the stimulus, different receptors and intermediates (adaptors, GTPases or kinases) are activated leading to the activation of the p38alpha MAPK cascade. This cascade is initiated by activation of MAPKKKs, which phosphorylate and activate MAPKKs (MKK3/6/4), which in turn lead to activation of MAPK14 through dual phosphorylation in Tyr and Thr. Once phosphorylated, MAPK14 phosphorylates a number of cytosolic and nuclear substrates, including transcription factors, which lead to the control of many cellular responses.

Mutations

Somatic

4 somatic mutations according to Ensembl: COSM21366; COSM20563; COSM35409; COSM12875.

Implicated in

Entity name

Hematopoietic malignancies

Disease

p38 MAPK, mainly the p38alpha isoform, is a key player in the maintenance of hematopoiesis homeostasis, as it balances both proliferative and growth inhibitory signals triggered by the growth factors and cytokines that regulate normal hematopoiesis. Alterations in this p38 MAPK-controlled balance may result in either overproduction or depletion of myelosuppressive cytokines leading to the development of certain bone marrow failure syndromes. For example, p38alpha is responsible for the enhanced stem cell apoptosis characteristic of low grade myeolodysplastic syndromes (MDSs). On the other hand, imbalance toward the proliferative side may conduct to the development of myeloproliferative syndromes (MPSs), such as leukemia, lymphomas and myelomas. In particular, p38alpha MAPK plays a pro-apoptotic role in chronic myeloid leukemia (CML). In fact, p38alpha MAP kinase pathway mediates the growth inhibitory effects of IFNalpha and STI-571, two drugs used in the CML treatment, which underscores the importance of this pathway in the generation of antileukemic responses.

Entity name

Alzheimers disease

Disease

Alzheimer is an incurable, neurodegenerative disease characterized by a progressive deterioration of the cognitive, memory and learning ability due to the accumulation of plaques containing amyloidogenic Abeta proteins and tangles containing hyperphosphorylated tau protein. The ASK1-MKK6-p38 signaling pathway participates in amyeloid precursor protein (APP) and tau phosphorylation in response to oxidative stress and contributes to the expression of the beta-secretase gene and the induction of neuronal apoptosis triggered by ROS.

Entity name

Parkinson disease

Disease

Parkinson is a degenerative disorder of the central nervous system characterized by muscle rigidity, tremor and loss of physical movement caused by a progressive loss of dopaminergic neurons. Mutations in alpha-synuclein are one of the main causes of Parkinson. alpha-synuclein activates p38alpha MAPK in human microglia promoting a potent inflammatory stimulation of microglial cells. Additionally, the p38alpha MAPK plays a role in dopaminergic neural apoptosis through the phosphorylation of p53 and expression of the pro-apoptotic protein Bax.

Entity name

Amyotrophic lateral sclerosis

Disease

ALS is a progressive, lethal, degenerative disorder of motor neurons leading to paralysis of voluntary muscles. Numerous evidences point to a role of p38 MAPK in the development and progression of ALS induced by mutations in SOD1 (superoxide dismutase 1) gene. Mutant SOD1 provokes aberrant oxyradical reactions that increase the activation of p38 MAPK in motor neurons and glial cells. This increase in active p38 MAPK may phosphorylate cytoskeletal proteins and activate cytokines and nitric oxide, thus contributing to neurodegeneration through different mechanisms including apoptosis.

Article Bibliography

Pubmed ID	Last Year	Title	Authors
10949032	2000	Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development.	Adams RH et al
16909017	2005	Inter- and intracellular signaling in amyotrophic lateral sclerosis: role of p38 mitogen-activated protein kinase.	Bendotti C et al
10581258	1999	Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation.	Bulavin DV et al
20626350	2010	Mechanisms and functions of p38 MAPK signalling.	Cuadrado A et al
17481747	2007	p38 MAP-kinases pathway regulation, function and role in human diseases.	Cuenda A et al
10915780	2000	The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.	D'Amico M et al
9365241	1997	Pro-apoptotic effect of the c-Abl tyrosine kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine.	Huang Y et al
19020042	2008	Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice.	Karunakaran S et al
15019567	2004	Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells.	Mathiasen JR et al
11571231	2001	Involvement of p38 kinase in hydroxyurea-induced differentiation of K562 cells.	Park JI et al
12725866	2003	The p38 mitogen-activated protein kinase pathway and its role in interferon signaling.	Platanias LC et al
14617800	2004	P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.	Porras A et al
15488025	2004	Expression of stress-activated kinases c-Jun N-terminal kinase (SAPK/JNK-P) and p38 kinase (p38-P), and tau hyperphosphorylation in neurites surrounding betaA plaques in APP Tg2576 mice.	Puig B et al
7923353	1994	A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins.	Rouse J et al
10811125	2000	A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents.	Sanchez-Prieto R et al
15719422	2005	Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease.	Silva RM et al
12684028	2003	H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK.	Tamagno E et al
12812752	2003	Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression.	Tortarolo M et al
19629069	2009	Signal integration by JNK and p38 MAPK pathways in cancer development.	Wagner EF et al
8910361	1996	Crystal structure of p38 mitogen-activated protein kinase.	Wilson KP et al
17351344	2007	p38 MAP kinase regulates stem cell apoptosis in human hematopoietic failure.	Zhou L et al
16844343	2007	Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1.	Zuluaga S et al

Other Information

Locus ID:

NCBI: 1432
MIM: 600289
HGNC: 6876
Ensembl: ENSG00000112062

Variants:

dbSNP: 1432
ClinVar: 1432
TCGA: ENSG00000112062
COSMIC: MAPK14

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000112062	ENST00000229794	Q16539
ENSG00000112062	ENST00000229794	A0A024RD15
ENSG00000112062	ENST00000229795	Q16539
ENSG00000112062	ENST00000229795	L7RSM2
ENSG00000112062	ENST00000310795	Q16539
ENSG00000112062	ENST00000468133	B4E0K5
ENSG00000112062	ENST00000472333	E7EX54
ENSG00000112062	ENST00000474429	H7C4E2
ENSG00000112062	ENST00000491957	B5TY33
ENSG00000112062	ENST00000622903	B5TY33

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
VEGF signaling pathway	KEGG	ko04370
Toll-like receptor signaling pathway	KEGG	ko04620
T cell receptor signaling pathway	KEGG	ko04660
Fc epsilon RI signaling pathway	KEGG	ko04664
Leukocyte transendothelial migration	KEGG	ko04670
GnRH signaling pathway	KEGG	ko04912
Progesterone-mediated oocyte maturation	KEGG	ko04914
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
Epithelial cell signaling in Helicobacter pylori infection	KEGG	ko05120
MAPK signaling pathway	KEGG	hsa04010
VEGF signaling pathway	KEGG	hsa04370
Toll-like receptor signaling pathway	KEGG	hsa04620
T cell receptor signaling pathway	KEGG	hsa04660
Fc epsilon RI signaling pathway	KEGG	hsa04664
Leukocyte transendothelial migration	KEGG	hsa04670
GnRH signaling pathway	KEGG	hsa04912
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
Epithelial cell signaling in Helicobacter pylori infection	KEGG	hsa05120
Shigellosis	KEGG	hsa05131
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
RIG-I-like receptor signaling pathway	KEGG	ko04622
RIG-I-like receptor signaling pathway	KEGG	hsa04622
Progesterone-mediated oocyte maturation	KEGG	hsa04914
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Pertussis	KEGG	ko05133
Pertussis	KEGG	hsa05133
Salmonella infection	KEGG	ko05132
Salmonella infection	KEGG	hsa05132
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Retrograde endocannabinoid signaling	KEGG	hsa04723
Retrograde endocannabinoid signaling	KEGG	ko04723
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
TNF signaling pathway	KEGG	hsa04668
TNF signaling pathway	KEGG	ko04668
Prolactin signaling pathway	KEGG	hsa04917
Prolactin signaling pathway	KEGG	ko04917
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
FoxO signaling pathway	KEGG	hsa04068
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Platelet activation	KEGG	hsa04611
Signaling pathways regulating pluripotency of stem cells	KEGG	hsa04550
Signaling pathways regulating pluripotency of stem cells	KEGG	ko04550
MAPK (p38) signaling	KEGG	hsa_M00689
MAPK (p38) signaling	KEGG	M00689
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Mitochondrial biogenesis	REACTOME	R-HSA-1592230
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	REACTOME	R-HSA-2151209
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade	REACTOME	R-HSA-168142
MyD88 cascade initiated on plasma membrane	REACTOME	R-HSA-975871
MAP kinase activation in TLR cascade	REACTOME	R-HSA-450294
activated TAK1 mediates p38 MAPK activation	REACTOME	R-HSA-450302
MAPK targets/ Nuclear events mediated by MAP kinases	REACTOME	R-HSA-450282
ERK/MAPK targets	REACTOME	R-HSA-198753
Activation of the AP-1 family of transcription factors	REACTOME	R-HSA-450341
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Toll Like Receptor 5 (TLR5) Cascade	REACTOME	R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	REACTOME	R-HSA-168643
NOD1/2 Signaling Pathway	REACTOME	R-HSA-168638
Hemostasis	REACTOME	R-HSA-109582
Platelet homeostasis	REACTOME	R-HSA-418346
Platelet sensitization by LDL	REACTOME	R-HSA-432142
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Signal amplification	REACTOME	R-HSA-392518
ADP signalling through P2Y purinoceptor 1	REACTOME	R-HSA-418592
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
p38MAPK events	REACTOME	R-HSA-171007
Nuclear Events (kinase and transcription factor activation)	REACTOME	R-HSA-198725
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
Regulation of mRNA stability by proteins that bind AU-rich elements	REACTOME	R-HSA-450531
KSRP (KHSRP) binds and destabilizes mRNA	REACTOME	R-HSA-450604
Cell-Cell communication	REACTOME	R-HSA-1500931
DSCAM interactions	REACTOME	R-HSA-376172
Developmental Biology	REACTOME	R-HSA-1266738
Myogenesis	REACTOME	R-HSA-525793
CDO in myogenesis	REACTOME	R-HSA-375170
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Oxidative Stress Induced Senescence	REACTOME	R-HSA-2559580
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Activity through Phosphorylation	REACTOME	R-HSA-6804756
Endocrine resistance	KEGG	ko01522
Endocrine resistance	KEGG	hsa01522
Neutrophil degranulation	REACTOME	R-HSA-6798695
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659
IL-17 signaling pathway	KEGG	ko04657
Fluid shear stress and atherosclerosis	KEGG	ko05418
IL-17 signaling pathway	KEGG	hsa04657
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA134963361	MAFA	Gene	Pathway	associated	23922006
PA162392499	JDP2	Gene	Pathway	associated	23922006
PA25084	ATF2	Gene	Pathway	associated	23922006
PA25085	ATF3	Gene	Pathway	associated	23922006
PA25268	BATF	Gene	Pathway	associated	23922006
PA28212	FOS	Gene	Pathway	associated	23922006
PA28213	FOSB	Gene	Pathway	associated	23922006
PA28214	FOSL1	Gene	Pathway	associated	23922006
PA28215	FOSL2	Gene	Pathway	associated	23922006
PA284	MAP2K7	Gene	Pathway	associated	20124951
PA30006	JUN	Gene	Pathway	associated	23922006
PA30007	JUNB	Gene	Pathway	associated	23922006
PA30008	JUND	Gene	Pathway	associated	23922006
PA30534	MAF	Gene	Pathway	associated	23922006
PA30535	MAFB	Gene	Pathway	associated	23922006
PA30538	MAFF	Gene	Pathway	associated	23922006
PA30539	MAFG	Gene	Pathway	associated	23922006
PA30540	MAFK	Gene	Pathway	associated	23922006
PA30584	MAP2K1	Gene	Pathway	associated	20124951
PA30587	MAP2K2	Gene	Pathway	associated	20124951
PA30588	MAP2K3	Gene	Pathway	associated	20124951, 23922006
PA30589	MAP2K4	Gene	Pathway	associated	20124951
PA30590	MAP2K5	Gene	Pathway	associated	20124951
PA30591	MAP2K6	Gene	Pathway	associated	20124951, 23922006
PA31781	NRL	Gene	Pathway	associated	23922006
PA7000	sorafenib	Chemical	Pathway	associated	20124951

References

Pubmed ID	Year	Title
37318032	2024	miR-200a-3p regulates epithelial-mesenchymal transition and inflammation in chronic rhinosinusitis with nasal polyps by targeting ZEB1 via ERK/p38 pathway.
37522419	2024	Up-regulation of Trim28 in pregnancy-induced hypertension is involved in the injury of human umbilical vein endothelial cells through the p38 signaling pathway.
37865350	2024	The lncRNA MEG3/miRNA-21/P38MAPK axis inhibits coxsackievirus 3 replication in acute viral myocarditis.
38301965	2024	CXCL13 promotes TNF-α synthesis in rheumatoid arthritis through activating ERK/p38 pathway and inhibiting miR-330-3p generation.
38368696	2024	Hepatic expression of tumor necrosis factor-α and evaluation of MAPK-p38 and NFκB signaling pathways in autoimmune hepatitis.
38395872	2024	Crosstalk with renal proximal tubule cells drives acidosis-induced inflammatory response and dedifferentiation of fibroblasts via p38-singaling.
38441376	2024	Phosphorylated p38 MAP kinase expression by leucocytes is increased in allergic humans and associated with IgE responses.
38533556	2024	YKL40 potentially via activating the P38 pathway in decreasing atherosclerotic plaque stability.
38597327	2024	Dynamically changed HSP70 after reperfusion following cerebral infarction in human and rats: correlation with p38 MAPK.
38597420	2024	CLCA1 exacerbates lung inflammation via p38 MAPK pathway in acute respiratory distress syndrome.
38730210	2024	Lack of p38 activation in T cells increases IL-35 and protects against obesity by promoting thermogenesis.
37318032	2024	miR-200a-3p regulates epithelial-mesenchymal transition and inflammation in chronic rhinosinusitis with nasal polyps by targeting ZEB1 via ERK/p38 pathway.
37522419	2024	Up-regulation of Trim28 in pregnancy-induced hypertension is involved in the injury of human umbilical vein endothelial cells through the p38 signaling pathway.
37865350	2024	The lncRNA MEG3/miRNA-21/P38MAPK axis inhibits coxsackievirus 3 replication in acute viral myocarditis.
38301965	2024	CXCL13 promotes TNF-α synthesis in rheumatoid arthritis through activating ERK/p38 pathway and inhibiting miR-330-3p generation.

Citation

Almudena Porras ; Carmen Guerrero

MAPK14 (mitogen-activated protein kinase 14)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/41292/js/gene-explorer/bioinfow.dep.usal.es/xgate/principal.php