DVL1 (dishevelled, dsh homolog 1 (Drosophila))

2011-06-01   Ho-Jin Lee , Jie J Zheng 

St Jude Childrens Research Hospital, Department of Structural Biology, 262 Danny Thomas Place, Memphis, TN 38105, USA





A human DVL1 cDNA was first isolated from a human adult caudate cDNA library by screening with a 200 bp RT-PCR fragment obtained from human fetal brain total RNA that was probed with oligonucleotides corresponding to the mouse Dishevelled homolog (Pizzuti et al., 1996). The cDNA recovered encoded a 670 amino acid protein that was termed DVL-1L. Around the same time, Semënov and Snyder (1997) cloned and characterized 3 human homologs of the Drosophila Dishevelled gene, one of which encoded DVL1, a 695-amino acid protein (GenBank: AF006011.1).


The DVL1 gene comprises 15 verified exons.


Atlas Image
Schematic diagram of DVL1 protein. Homology model respective structure of DIX, PDZ, or DEP domain in DVL1 protein was generated by using X-ray and NMR structures (for DIX domain, PDB code: 3PZ8; for PDZ domain, PDB codes: 1L06 and 1MC7; for DEP domain, PDB code: 1FSH).


Human DVL1 encodes DVL1 protein, which contains 695 amino acid residues (size 75.2 kDa) (Semënov and Snyder, 1997). DVL1 comprises three domains, DIX (aa 1-82, DIshevelled-aXin), PDZ (aa 249-342, Post Synaptic Density-95, Discs large and Zonula-occludens 1), and DEP (aa 404-502, Dishevelled-EGL-10-Pleckstrin) (Wharton, 2003; Malbon and Wang, 2006; Wallingford and Habas, 2005). In the mouse, the DIX domain of Dvls can associate with the DIX domain of Axin and Dvls (Schwarz-Romond et al., 2007a; Schwarz-Romond et al., 2007b). The PDZ domain of Dvls is the protein-protein interaction module (Wong et al., 2003; Lee and Zheng, 2010) and at least 20 Dvl-binding partners were reported (Wallingford and Habas, 2005). The DEP domain of Dvl proteins has a polybasic stretch region that is responsible for its membrane-targeting activity (Wong et al., 2000; Simons et al., 2009). Furthermore, Dvl proteins have conserved regions harboring positively charged (basic) amino acid residues, proline-rich putative Src-homology 3 (SH3) binding domains (Penton et al., 2002), and highly conserved C-terminal regions (Wallingford and Habas, 2005), but their roles are unknown.

Structure. The overall structure of the intact DVL1 protein remains unknown; however, each individual domain in DVL1 has been investigated. The 3D structure of the DIX domain of Dvl-1 has not been reported. The homology model of the DVL1 DIX domain was generated from the 3D structure of the Axin DIX domain (PDB code: 1WSP) and that of a mutant DIX(Y17D) was solved by using X-ray crystallography (PDB code: 3PZ8), which consists of 4 beta-sheets and 1 helix structures (Schwarz-Romond et al., 2007a; Liu et al., 2011). The structure of DVL1s PDZ domain comprises 6 beta-sheets (betaA~betaF) and 2 alpha-helices (alphaA and alphaB) (Wong et al., 2003). The DEP domain of DVL1 consists of a helix bundle with three a-helices (H1-H3), a beta-hairpin "arm" composed of two beta-strands (B1 and B2) between H1 and H2, and two short beta-strands (B3 and B4) (Wong et al., 2000).


DVL1 gene is found in fetal and adult tissues, including brain, lung, kidney, skeletal muscle, and heart; according to Northern blot analysis, the highest mRNA levels are found in adult skeletal muscle, pancreas, and heart muscle (Pizzuti et al., 1996).


Normally present in cytoplasm. After activation of Wnt signaling, the translocation of DVLs is occurred from the cytoplasm to the plasma membrane (Park et al., 2005; Simons et al., 2009) and to the nucleus (Torres and Nelson, 2000; Itoh et al., 2005; Gan et al., 2008).


Dvl family proteins mediate Wnt signaling pathways: Wnt/beta-catenin, Wnt/JNK (planar cell polarity or convergent extension), and Wnt/Ca2+ signaling (Klingensmith et al., 1994; Li et al., 1999; Boutros and Mlodzik, 1999; Wallingford et al., 2000; Gao and Chen, 2010). The DIX and PDZ domains are used for canonical Wnt signaling; the PDZ and DEP domains are used for non-canonical Wnt signaling. After Wnt activates signaling, CK1epsilon, CKII, PKCalpha, or Par-1 kinases hyperphosphorylate Dvl proteins on serine/threonine residues (Yanagawa et al., 1995; Peters et al., 1999; Sakanaka et al., 1999; Kishida et al., 2001; Schulte et al., 2005; Kibardin et al., 2006; Klimowski et al., 2006; Bilic et al., 2007; Zhang et al., 2007; Zeng et al., 2008). DVL1 can interact with a variety of other binding partners including protein phosphatases and kinases (Boutros and Mlodzik, 1999; Williams et al., 2005).

Binding partners
- AXIN interacts with the DIX domain of DVLs, which leads to the activation of beta-catenin-mediated signaling (Li et al., 1999; Smalley et al., 1999; Cliffe et al., 2003; Kishida et al., 1999; Schwarz-Romond et al., 2007a; Schwarz-Romond et al., 2007b; Fiedler et al., 2011).
- BP75 (bromodomain-containing M(r) 75000 protein) binds to the DIX domain of mouse Dvl1 in mammalian cells and enhances Wnt signaling by inactivating GSK3beta (Kim et al., 2003).
- CK1epsilon (casein kinase Iepsilon) binds to the Dvl proteins and increases the phosphorylation of DVLs in a variety of tissue culture and in vitro assays (Peters et al., 1999; Sakanaka et al., 1999; Kishida et al., 2001). CK1epsilon phosphorylates two highly conserved residues, S139 and S142, of mouse Dvl1 protein, as confirmed by mass spectroscopy. Phosphoserines -139 and -142 are positive regulators of Dvl1-dependent Wnt signal transduction (Klimowski et al., 2006). In Drosophila, CK1epsilon phosphorylates the Ser236 residue in Dsh protein as confirmed by mutagenesis analysis (Klein et al., 2006). In Xenopus, CK1epsilon activates the Wnt/beta-catenin signaling pathway positively. The interaction between the kinase domain of CK1epsilon and the PDZ domain of Xenopus Dishevelled (Xdsh) was identified by a yeast two-hybrid assay (Peters et al., 1999). However, another study suggested that the entire DEP domain, but not the PDZ domain, is necessary for the binding of DVL1 to CK1epsilon in mammalian intact cell assays (Kishida et al., 2001). In Drosophila, studies suggested that CK1epsilon facilitates both Wnt/beta-catenin and Wnt/PCP signaling pathways (Strutt et al., 2006; Klein et al., 2006). Consistent with this finding, CK1epsilon activates Dvl proteins via non-canonical Wnt ligands in SN4741 cells, suggesting that CK1epsilon-mediated phosphorylation of Dvl proteins may be a common step in both canonical and non-canonical pathways (Bryja et al., 2007).
- CKII (casein kinase II) is a serine/threonine kinase that can phosphorylate and associate with the PDZ domain of Drosophila Dsh (or DVLs) (Willert et al., 1997; Lee et al., 1999).
- Diversin regulates heart formation and gastrulation movements during development. Diversins ankyrin repeats are necessary for interaction with the DVL DEP domain, for activation of the non-canonical Wnt signaling pathway, and for other biological responses (Moeller et al., 2006).
- Dapper (Dpr) binds to the PDZ domain of DVL1, which inhibits the Wnt/beta-catenin signaling (Wong et al., 2003). However,another study showed that human DPR1 can bind the DEP domain of DVL1 and inhibit Wnt signaling by promoting DVL1 degradation (Zhang et al., 2006).
- Daam1, a Formin-Homology (FH) protein, binds to both DVL and Rho proteins and mediates Wnt-induced Dvl1-Rho complex formation. Xenopus Daam1 regulates gastrulation (Habas et al., 2001).
- EphrinB1 interacts with the PDZ domain of Dishevelled. In Xenopus embryos, EphrinB1 plays a role in retinal progenitor cell movement into the eye field through an interaction with DVL (Tanaka et al., 2003; Lee et al., 2006; Lee HS et al., 2009). Phosphorylation of tyrosines 324 and 325 disrupts the EphrinB1/Dsh interaction, thus modulating retinal progenitor movement that is dependent on the planar cell polarity pathway (Lee HS et al., 2009).
- Frat protein was originally isolated on the basis of its tumor-promoting activity in human lymphocytes (Jonkers et al., 1997). It also binds to the basic region (aa 220-230) of DVL1 (Li et al., 1999; Hino et al., 2003), an interaction that is enhanced by CK1epsilon, which activates Wnt/beta-catenin signaling (Hino et al., 2003).
- Frizzled (Fz) protein, a key component of Wnt signaling, interacts with Dvl proteins (Wong et al., 2003; Shafer et al., 2011). NMR studies showed that a peptide derived from a conserved motif (KTxxxW) located two amino acids C-terminal to the seventh transmembrance domain of Fz directly binds to the PDZ domain of Dvl-1, implying that its interaction is necessary for activating the Wnt/beta-catenin signaling (Wong et al., 2003). Interestinly, Dvl-1 can inhibit PCP signaling by increasing hyperphosphorylation of Fz3 and preventing its internalization (Shafer et al., 2011).
- Idax (Inhibition of the Dvl and AXin complex) bound to the PDZ domain of DVL was identified in a rat brain cDNA library that was screened by the yeast two-hybrid method (Hino et al., 2001). Idax interacts with DVL in intact cells also. NMR spectroscopy identified the minimum region in rat Idax protein required for binding to mouse Dvl1 PDZ domain as the internal sequence of the KTxxxI motif (London et al., 2004). Idax suppresses the Wnt3a-dependent accumulation of beta-catenin and activation of Tcf in L cells (Hino et al., 2001). The levels of CXXC4 mRNA, which encodes the protein Idax, in renal cell carcinoma were significantly lower in patients with metastases than in patients without metastases (P=0.0016) (Kojima et al., 2009).
- Naked cuticle (Nkd) regulates early Wnt activity by acting as an inducible antagonist. The Nkd EFX domain interacts with the basic/PDZ domain of Drosophila Dsh or DVLs in the yeast two-hybrid assay (Wharton et al., 2001).
- MuSK kinase domain interacts with Dvl1 DEP domain in a mouse muscle cell line and in HEK293 cells transfected with the mouse constructs, which plays an important role in the agrin- and neuro-induced AChR (acethylcholine receptor) clustering (Luo et al., 2002). In Dvl1 mutant mice AchR clusters had a more disperse distribution at the endplate (Henriquez et al., 2008).
- PAR-1 is a serine/threonine kinase. In Drosophila, Par-1 binds to and phosphorylates Dsh/Dvl protein and promotes Wnt/beta-catenin signaling at the expense of JNK signaling (Sun et al., 2001). Par-1 target sites in Dsh are essential for proper Dsh translocation from the cytoplasmic vesicles to the cell cortex but not for Dsh activity in the canonical Wnt/beta-catenin pathway. Different PAR-1 isoforms mediate two distinct and essential roles in Xenopus axial development. PAR-1BY plays an essential role in the PCP branch and mediates Dsh membrane localization while PAR-1A and PAR-BX are essential for canonical Wnt signaling, possibly via targets other than Dishevelled (Ossipova et al., 2005). Mammalian Par-1b promotes cell-cell adhesion and inhibits Dvl-mediated transformation of Madin-Darby canine kidney cells.
- PIP5K1 (phosphatidylinositol-4-phosphate 5-kinase type I) and DVL co-immunoprecipitate when they are overexpressed in HEK293 cells. The N-terminal half of the PIP5K1beta kinase domain interacts with Dvl1 fragment that contains the DIX and PDZ domains; Wnt3a may regulate this interaction (Pan et al., 2008).
- Ror2 is a receptor tyrosin kinase (RTK) binds the Dvl C-terminus (Witte et al., 2010).
- Syndecan-4 (Syn4) interacts with Dvl protein and also functionally and biochemically with the Wnt receptor Fz7 in Xenopus embryos (Muñoz et al., 2006).
- Transmembrane 88 (TMEM88), a two-transmembrane-type protein, interacts with the PDZ domain of Dvl. Using NMR spectroscopy, the interaction between the C-terminal tail of TMEM88 and the PDZ domain of Dvl-1 was confirmed (Lee et al., 2010). In HEK293 cells, TMEM88 attenuated the Wnt/beta-catenin signaling induced by Wnt-1 ligand in a dose-dependent manner, and TMEM88 knockdown by RNAi increased Wnt activity. In Xenopus, TMEM88 protein is sublocalized at the cell membrane and inhibits Wnt signaling induced by Xdsh, but not beta-catenin (Lee et al., 2010).


Three DVL genes (DVL1, DVL2, and DVL3) have been isolated in mammals and Xenopus. Dvl homologs are conserved in Drosophila (dishevelled, dsh).

Implicated in

Entity name
Breast cancers
The DVL1 gene is amplified and DVL1 protein is over-expressed in 13 of 14 primary breast cancers examined. DVL1 protein is prominent in the cytoplasm of cancer cells, but not in normal epithelial cells of the mammary duct or in myoepithelial cells (Nagahata et al., 2003; Schlange et al., 2007). In invasive ductal carcinoma of the breast, immunohistochemical analysis of 96 tumor samples showed that 30% of tumors displayed both nuclear and cytoplasmic staining of DVL protein, while 52% showed nuclear loclalization. There is a correlation between nuclear localization of DVL and beta-catenin (p
Entity name
Cervical squamous cell carcinoma
Up-regulation and overproduction of DVL1 mRNA were found in these malignant cells (Okino et al., 2003). DVL1 protein was prominent in the cytoplasm of cancer cells whereas it was unreactive in the surrounding normal cervical squamous cells (Okino et al., 2003).
Entity name
Prostate cancer
Semi-quantitative PCR in 20 primary prostate cancers and assessed the protein expression revealed that DVL1 is significantly overexpressed in prostate cancer (65%). A correlation between DVL1 expression and beta-catenin expression was confirmed (Mizutani et al., 2005).
Entity name
Lung cancer
RT-PCR of 13 matched normal and invasive squamous cell carcinoma samples revealed that the tumors significantly overexpressed Notch and Wnt pathway family members, including DVL1 (P=0.003), LRP8 (P=0.008) and NOTCH2 (P=0.029) (Garnis et al., 2005). All DVL family members are expressed in non-small cell lung cancer (Wei et al., 2008). The expression levels of DVL1 and DVL3 are significantly higher in nodal metastases than in primary growths, and DVL1 expression is correlated with beta-catenin expression in the metastases (Wei et al., 2008).
Entity name
Irritable bowel disease (IBD)-related colon cancer
You et al. (2007) found that DVL1 was uniformly expressed in the affected tissues of IBD patients and sporadic colon cancer patients, even though no DVL1 expression was seen in the normal tissues of the same patients. Remarkably, DVL2 and DVL3 were expressed in all normal mucosa samples tested, and were expressed in sporadic colon cancer but were not expressed in colon cancers arising in patients with IBD (You et al., 2007).


Pubmed IDLast YearTitleAuthors
175698652007Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.Bilic J et al
105078371999Dishevelled: at the crossroads of divergent intracellular signaling pathways.Boutros M et al
172446472007Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism.Bryja V et al
127811352003A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling.Cliffe A et al
190089502008Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.Etheridge SL et al
212453032011Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin.Fiedler M et al
183470712008Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction.Gan XQ et al
200069832010Dishevelled: The hub of Wnt signaling.Gao C et al
156157702005Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis.Garnis C et al
193836052009Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.Grandy D et al
117794612001Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.Habas R et al
124217202002Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.Hamblet NS et al
190200932008Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin.Henriquez JP et al
111132072001Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.Hino S et al
125565192003Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin.Hino S et al
157207242005Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling.Itoh K et al
185387362008DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications.Jiang X et al
90343271997Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas.Jonkers J et al
167904802006Metastasis-associated kinase modulates Wnt signaling to regulate brain patterning and morphogenesis.Kibardin A et al
129417962003BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta.Kim S et al
114258582001Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon.Kishida M et al
103301811999DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.Kishida S et al
168249222006CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila.Klein TJ et al
169655382006Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling.Klimowski LK et al
82881251994The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.Klingensmith J et al
189316982009Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling.Kojima T et al
210449572010Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein.Lee HJ et al
196371792009Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled.Lee HJ et al
205098692010PDZ domains and their binding partners: structure, specificity, and modification.Lee HJ et al
163620522006Dishevelled mediates ephrinB1 signalling in the eye field through the planar cell polarity pathway.Lee HS et al
190052142009Fibroblast growth factor receptor-induced phosphorylation of ephrinB1 modulates its interaction with Dishevelled.Lee HS et al
104097111999Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway.Lee JS et al
104289611999Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.Li L et al
92989011997Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1.Lijam N et al
211894232011Molecular basis of Wnt activation via the DIX domain protein Ccd1.Liu YT et al
153132102004Interaction between the internal motif KTXXXI of Idax and mDvl PDZ domain.London TB et al
121654712002Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.Luo ZG et al
165643342006Dishevelled: a mobile scaffold catalyzing development.Malbon CC et al
164571552005Upregulation and overexpression of DVL1, the human counterpart of the Drosophila dishevelled gene, in prostate cancer.Mizutani K et al
170327652006Diversin regulates heart formation and gastrulation movements in development.Moeller H et al
166040632006Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos.Muñoz R et al
128248762003Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers.Nagahata T et al
128836842003Up-regulation and overproduction of DVL-1, the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma.Okino K et al
159357732005Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development.Ossipova O et al
187724382008Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.Pan W et al
159362752005Subcellular localization and signaling properties of dishevelled in developing vertebrate embryos.Park TJ et al
120724702002A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin.Penton A et al
105176321999Casein kinase I transduces Wnt signals.Peters JM et al
88173291996cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.Pizzuti A et al
183376232007Wnt signaling pathway in invasive ductal carcinoma of the breast: relationship between beta-catenin, dishevelled and cyclin D1 expression.Prasad CP et al
105359591999Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function.Sakanaka C et al
178974392007Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation.Schlange T et al
157481722005Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation.Schulte G et al
176069952007Dynamic recruitment of axin by Dishevelled protein assemblies.Schwarz-Romond T et al
91928511997Human dishevelled genes constitute a DHR-containing multigene family.Semënov MV et al
213165862011Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance.Shafer B et al
163003982005Identification of a specific inhibitor of the dishevelled PDZ domain.Shan J et al
187801462009Optimizing Dvl PDZ domain inhibitor by exploring chemical space.Shan J et al
192344542009Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization.Simons M et al
103296281999Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.Smalley MJ et al
168249212006Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila.Strutt H et al
114332942001PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.Sun TQ et al
125741212003Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion.Tanaka M et al
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185606112008Therapeutic use of PDZ protein-protein interaction antagonism.Wang NX et al
186929362008Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression.Wei Q et al
124901942003Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction.Wharton KA Jr et al
92146261997Casein kinase 2 associates with and phosphorylates dishevelled.Willert K et al
202155272010Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2.Witte F et al
146365822003Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.Wong HC et al
111019022000Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway.Wong HC et al
77442501995The dishevelled protein is modified by wingless signaling in Drosophila.Yanagawa S et al
176717212007Expression of Wnt pathway components frizzled and disheveled in colon cancer arising in patients with inflammatory bowel disease.You XJ et al
180775882008Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.Zeng X et al
164463662006Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation.Zhang L et al
175583962007Dishevelled promotes axon differentiation by regulating atypical protein kinase C.Zhang X et al
192524992009Inhibition of Wnt signaling by Dishevelled PDZ peptides.Zhang Y et al

Other Information

Locus ID:

NCBI: 1855
MIM: 601365
HGNC: 3084
Ensembl: ENSG00000107404


dbSNP: 1855
ClinVar: 1855
TCGA: ENSG00000107404


Gene IDTranscript IDUniprot

Expression (GTEx)



PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
Notch signaling pathwayKEGGko04330
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
Notch signaling pathwayKEGGhsa04330
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
WNT mediated activation of DVLREACTOMER-HSA-201688
Disassembly of the destruction complex and recruitment of AXIN to the membraneREACTOMER-HSA-4641262
Degradation of DVLREACTOMER-HSA-4641258
Negative regulation of TCF-dependent signaling by DVL-interacting proteinsREACTOMER-HSA-5368598
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected


Pubmed IDYearTitleCitations
204127732010The Hippo pathway regulates Wnt/beta-catenin signaling.199
183470712008Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction.96
181625512008Mechanism of activation of the Formin protein Daam1.74
180938022008Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.60
258910772015Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases.46
146847392004NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.45
128248762003Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers.38
203887312010Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization.38
166217892006A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells.35
276929842016Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled.35


Ho-Jin Lee ; Jie J Zheng

DVL1 (dishevelled, dsh homolog 1 (Drosophila))

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/463/dvl1-(dishevelled-dsh-homolog-1-(drosophila))