UCSF, Department of Microbiology, Immunology, San Francisco, CA 94143-0414, USA
KLRK1 encodes a type II transmembrane-anchored glycoprotein that is expressed as a disulfide-linked homodimer on the surface of Natural Killer (NK) cells, gamma\/delta TcR+ T cells, CD8+ T cells, and a minor subset of CD4+ T cells. It associates non-covalently with the DAP10 signaling protein and provides activating or costimulatory signals to NK cells and T cells. NKG2D binds to a family of glycoproteins, in humans the MICA, MICB, and ULBP1-6 membrane proteins, which are frequently expressed on cells that have become infected with pathogens or undergone transformation.
NCBI: 22914 MIM: 611817 HGNC: 18788 Ensembl: ENSG00000213809
dbSNP: 22914 ClinVar: 22914 TCGA: ENSG00000213809 COSMIC: KLRK1
Lewis L Lanier
KLRK1 (killer cell lectin-like receptor subfamily K, member 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-06-01
Online version: http://atlasgeneticsoncology.org/gene/41094/css/lib/js/lib/favicon/favicon-32x32.png
2007-07-01 KLRK1 (killer cell lectin-like receptor subfamily K, member 1) by Lewis L Lanier  Affiliation