Department of Biology, Faculty of Science, Payame Noor University, Tehran, Iran. firstname.lastname@example.org
MicroRNAs (miRNAs) are a class of small regulatory RNAs (20-23 nucleotides long) that have been found to play a critical role in the wide spectrum of biological processes. These small endogenous noncoding RNAs are able to negatively regulate gene expression by pairing with the 3-untranslated region (3-UTR) of their target mRNA. miR-150 is a short and single-stranded miRNA, encoded by a gene located at 19q13.33 in Homo sapiens, which is processed to two mature forms (miR-150-5p and miR-150-3p). It has proven to be a pivotal miRNA engaged in the development of hematologic malignancies, normal haematopoiesis, differentiation of B and T cells, and a number of tumours including breast, osteosarcoma, lung, gastric cancer and etc.
Atlas Genet Cytogenet Oncol Haematol. 2016-12-01
Online version: http://atlasgeneticsoncology.org/gene/50556/mir150