CRLF2 is a member of type I cytokine receptor family. CRLF2 forms a functional complex with IL-7 receptor α chain and thymic stromal lymphopoietin, this complex induces the activation of signal transducers and activators of transcription proteins. The overexpression of CRLF2 induced by genetic rearrangements has been described in acute lymphoblastic leukemia.
Dafné Moreno-Lorenzana ; Rocío Juárez-Velázquez ; Daniel MartÍnez-Anaya ; Patricia Péez-Vera
CRLF2 (Cytokine receptor like factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2019-02-01
Online version: http://atlasgeneticsoncology.org/gene/51262/crlf2