University of Milan, Department of Health Sciences, Milan Italy Nazanin.abazari@studenti.unimi.it; alessandro.beghini@unimi.it
CSNK2A2 gene, 16q21, has a role in regulating the phosphorylation and circulation of old proteasomes by encoding the catalytic α subunit of casein kinase 2 (CK2α). Casein kinase 2 is a serine\/threonine protein kinase that phosphorylates acidic proteins. It can regulate Wnt signalling by phosphorylating CTNNB1 and the transcription factor LEF1 and for this reason, it is involved in some cellular key processes such as cell cycle progression, inhibition of apoptosis, DNA damage repair, differentiation and transcription but also viral infection. CSNK2A2 is a cancer-related gene and its upregulation has been detected is many cancers such as glioblastoma multiforme, colorectal cancer, breast cancer and ovarian cancer, and also in some diseases such as diabetes, theileriasis in cattle and distal muscular dystrophy with anterior tibial onset in mice are associated with CSNK2A2.
NCBI: 1459 MIM: 115442 HGNC: 2459 Ensembl: ENSG00000070770
dbSNP: 1459 ClinVar: 1459 TCGA: ENSG00000070770 COSMIC: CSNK2A2
Nazanin Abazari ; Alessandro Beghini
CSNK2A2 (casein kinase 2 alpha 2)
Atlas Genet Cytogenet Oncol Haematol. 2020-11-01
Online version: http://atlasgeneticsoncology.org/gene/40171/css/lib/gene-fusions/js/web-card-_common.js