PIM1

Identity

HGNC	PIM1
Location	6p21.2

DNA/RNA

Description	5 kb of genomic DNA; 6 exons
Transcription	2.6 kb mRNA; coding sequence 941 bp

Protein

Description	313 amino acids, 36 kDa; protein kinase domain, ATP-binding site
Expression	plays a role in signal transduction in blood cells
Function	serine/threonine-protein kinase; regulated by hematopoietic cytokine receptors; synergy with c-MYC in cell proliferation and in apoptosis induction (through an enhancement of the activation of caspase-3 -like proteases; Cdc25A (cell cycle phosphatase) is a substrate for Pim-1

Implicated in

Entity	t(3;6)(q27;p21.2) diffuse large B-cell lymphoma (DLCL) --> BCL6 / PIM1
Note	only 1 case to date
Disease	PROGNOSIS
Hybrid/Mutated Gene	5' PIM1 - 3' BCL6 fusion transcript; it is supposed that substitution of the promoter of BCL6 may be responsible for BCL6 deregulation

External links

	Nomenclature
HGNC	PIM1   8986
Entrez_Gene	PIM1  5292  pim-1 oncogene
	Cards
Atlas	PIM1ID261
GeneCards	PIM1
Ensembl	PIM1 [Search_View]   ENSG00000137193 [Gene_View]
Genatlas	PIM1
GeneLynx	PIM1
eGenome	PIM1
euGene	5292
	Genomic and cartography
GoldenPath	PIM1  -  6p21.2   chr6:37245964-37251182 +  6p21   [Description]    (hg18-Mar_2006)
Ensembl	PIM1 - 6p21 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PIM1
	Gene and transcription
Genbank	AK309347 [ ENTREZ ]
Genbank	BC020224 [ ENTREZ ]
Genbank	CR591847 [ ENTREZ ]
Genbank	DQ022562 [ ENTREZ ]
Genbank	M16750 [ ENTREZ ]
RefSeq	NM_002648 [ SRS ]    NM_002648 [ ENTREZ ]
RefSeq	AC_000049 [ SRS ]    AC_000049 [ ENTREZ ]
RefSeq	AC_000138 [ SRS ]    AC_000138 [ ENTREZ ]
RefSeq	NC_000006 [ SRS ]    NC_000006 [ ENTREZ ]
RefSeq	NT_007592 [ SRS ]    NT_007592 [ ENTREZ ]
RefSeq	NW_001838980 [ SRS ]    NW_001838980 [ ENTREZ ]
RefSeq	NW_923073 [ SRS ]    NW_923073 [ ENTREZ ]
AceView	PIM1 AceView - NCBI
Unigene	Hs.81170 [ SRS ]    Hs.81170 [ NCBI ]     HS81170 [ spliceNest ]
Fast-db	9481 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P11309 [ SRS]    P11309 [ EXPASY ]     P11309 [ INTERPRO ]     P11309 [ UNIPROT ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
Interpro	IPR017348 STPK_Pim-1 [ SRS ]    IPR017348 STPK_Pim-1 [ EBI ]
CluSTr	P11309
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P11309 PIM1_HUMAN [ Domain structure ]   P11309 PIM1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P11309
PDB	1XQZ [ SRS ]    1XQZ [ PdbSum ],   1XQZ [ IMB ]   1XQZ [ RSDB ]
PDB	1XR1 [ SRS ]    1XR1 [ PdbSum ],   1XR1 [ IMB ]   1XR1 [ RSDB ]
PDB	1XWS [ SRS ]    1XWS [ PdbSum ],   1XWS [ IMB ]   1XWS [ RSDB ]
PDB	1YHS [ SRS ]    1YHS [ PdbSum ],   1YHS [ IMB ]   1YHS [ RSDB ]
PDB	1YI3 [ SRS ]    1YI3 [ PdbSum ],   1YI3 [ IMB ]   1YI3 [ RSDB ]
PDB	1YI4 [ SRS ]    1YI4 [ PdbSum ],   1YI4 [ IMB ]   1YI4 [ RSDB ]
PDB	1YWV [ SRS ]    1YWV [ PdbSum ],   1YWV [ IMB ]   1YWV [ RSDB ]
PDB	1YXS [ SRS ]    1YXS [ PdbSum ],   1YXS [ IMB ]   1YXS [ RSDB ]
PDB	1YXT [ SRS ]    1YXT [ PdbSum ],   1YXT [ IMB ]   1YXT [ RSDB ]
PDB	1YXU [ SRS ]    1YXU [ PdbSum ],   1YXU [ IMB ]   1YXU [ RSDB ]
PDB	1YXV [ SRS ]    1YXV [ PdbSum ],   1YXV [ IMB ]   1YXV [ RSDB ]
PDB	1YXX [ SRS ]    1YXX [ PdbSum ],   1YXX [ IMB ]   1YXX [ RSDB ]
PDB	2BIK [ SRS ]    2BIK [ PdbSum ],   2BIK [ IMB ]   2BIK [ RSDB ]
PDB	2BIL [ SRS ]    2BIL [ PdbSum ],   2BIL [ IMB ]   2BIL [ RSDB ]
PDB	2BZH [ SRS ]    2BZH [ PdbSum ],   2BZH [ IMB ]   2BZH [ RSDB ]
PDB	2BZI [ SRS ]    2BZI [ PdbSum ],   2BZI [ IMB ]   2BZI [ RSDB ]
PDB	2BZJ [ SRS ]    2BZJ [ PdbSum ],   2BZJ [ IMB ]   2BZJ [ RSDB ]
PDB	2BZK [ SRS ]    2BZK [ PdbSum ],   2BZK [ IMB ]   2BZK [ RSDB ]
PDB	2C3I [ SRS ]    2C3I [ PdbSum ],   2C3I [ IMB ]   2C3I [ RSDB ]
PDB	2J2I [ SRS ]    2J2I [ PdbSum ],   2J2I [ IMB ]   2J2I [ RSDB ]
PDB	2O3P [ SRS ]    2O3P [ PdbSum ],   2O3P [ IMB ]   2O3P [ RSDB ]
PDB	2O63 [ SRS ]    2O63 [ PdbSum ],   2O63 [ IMB ]   2O63 [ RSDB ]
PDB	2O64 [ SRS ]    2O64 [ PdbSum ],   2O64 [ IMB ]   2O64 [ RSDB ]
PDB	2O65 [ SRS ]    2O65 [ PdbSum ],   2O65 [ IMB ]   2O65 [ RSDB ]
PDB	2OI4 [ SRS ]    2OI4 [ PdbSum ],   2OI4 [ IMB ]   2OI4 [ RSDB ]
PDB	3C4E [ SRS ]    3C4E [ PdbSum ],   3C4E [ IMB ]   3C4E [ RSDB ]
HPRD	01292
	Protein Interaction databases
DIP	P11309
IntAct	P11309
	Polymorphism : SNP, mutations, diseases
OMIM	164960    [ map ]
GENECLINICS	164960
SNP	PIM1 [dbSNP-NCBI]
SNP	NM_002648 [SNP-NCI]
SNP	PIM1 [GeneSNPs - Utah]  PIM1] [HGBASE - SRS]
HAPMAP	PIM1 [HAPMAP]
COSMIC	PIM1 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	PIM1 [Translocation breakpoints In Cancer]
HGMD	PIM1
	General knowledge
Family Browser	PIM1 [UCSC Family Browser]
SOURCE	NM_002648
SMD	Hs.81170
SAGE	Hs.81170
GO	nucleotide binding [Amigo]  nucleotide binding
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	plasma membrane [Amigo]  plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	cell proliferation [Amigo]  cell proliferation
GO	transferase activity [Amigo]  transferase activity
GO	manganese ion binding [Amigo]  manganese ion binding
GO	negative regulation of apoptosis [Amigo]  negative regulation of apoptosis
GO	metal ion binding [Amigo]  metal ion binding
KEGG	Jak-STAT signaling pathway
PubGene	PIM1
TreeFam	PIM1
CTD	5292 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PIM1 Related clones (RZPD - Berlin)
	PubMed
PubMed	59 Pubmed reference(s) in LocusLink

Bibliography

The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases.

Selten G, Cuypers HT, Boelens W, Robanus-Maandag E, Verbeek J, Domen J, van Beveren C, Berns A

Cell. 1986 ; 46 (4) : 603-611.

PMID 3015420

Cloning and characterization of the human PIM-1 gene: a putative oncogene related to the protein kinases.

Meeker TC, Nagarajan L, ar-Rushdi A, Croce CM

Journal of cellular biochemistry. 1987 ; 35 (2) : 105-112.

PMID 3429489

Pim-1 kinase stimulates c-Myc-mediated death signaling upstream of caspase-3 (CPP32)-like protease activation.

Mochizuki T, Kitanaka C, Noguchi K, Sugiyama A, Kagaya S, Chi S, Asai A, Kuchino Y

Oncogene. 1997 ; 15 (12) : 1471-1480.

PMID 9333023

Pim-1 kinase and p100 cooperate to enhance c-Myb activity.

Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA

Molecular cell. 1998 ; 2 (4) : 417-425.

PMID 9809063

Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway.

Mochizuki T, Kitanaka C, Noguchi K, Muramatsu T, Asai A, Kuchino Y

The Journal of biological chemistry. 1999 ; 274 (26) : 18659-18666.

PMID 10373478

Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.

Shirogane T, Fukada T, Muller JM, Shima DT, Hibi M, Hirano T

Immunity. 1999 ; 11 (6) : 709-719.

PMID 10626893

Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples.

Yoshida S, Kaneita Y, Aoki Y, Seto M, Mori S, Moriyama M

Oncogene. 1999 ; 18 (56) : 7994-7999.

PMID 10637510

Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1).

Koike N, Maita H, Taira T, Ariga H, Iguchi-Ariga SM

FEBS letters. 2000 ; 467 (1) : 17-21.

PMID 10664448

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Last year publications	automatic search in PubMed

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Contributor(s)

Written	08-2000	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . PIM1. Atlas Genet Cytogenet Oncol Haematol. August 2000 . URL : http://AtlasGeneticsOncology.org/Genes/PIM1ID261.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:16:22 2008