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PIM1 (pim-1 oncogene)

Identity

HGNC (Hugo) PIM1
LocusID (NCBI) 5292
Location 6p21.2
Location_base_pair Starts at 37137922 and ends at 37143204 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Description 5 kb of genomic DNA; 6 exons
Transcription 2.6 kb mRNA; coding sequence 941 bp

Protein

Description 313 amino acids, 36 kDa; protein kinase domain, ATP-binding site
Expression plays a role in signal transduction in blood cells
Function serine/threonine-protein kinase; regulated by hematopoietic cytokine receptors; synergy with c-MYC in cell proliferation and in apoptosis induction (through an enhancement of the activation of caspase-3 -like proteases; Cdc25A (cell cycle phosphatase) is a substrate for Pim-1

Implicated in

Entity t(3;6)(q27;p21.2) diffuse large B-cell lymphoma (DLCL) --> BCL6 / PIM1
Note only 1 case to date
Hybrid/Mutated Gene 5' PIM1 - 3' BCL6 fusion transcript; it is supposed that substitution of the promoter of BCL6 may be responsible for BCL6 deregulation
  

External links

Nomenclature
HGNC (Hugo)PIM1   8986
Entrez_Gene (NCBI)PIM1  5292  pim-1 oncogene
Cards
AtlasPIM1ID261
GeneCards (Weizmann)PIM1
Ensembl (Hinxton)ENSG00000137193 [Gene_View]  chr6:37137922-37143204 [Contig_View]  PIM1 [Vega]
AceView (NCBI)PIM1
Genatlas (Paris)PIM1
euGene (Indiana)5292
SOURCE (Stanford)NM_001243186 NM_002648
Genomic and cartography
GoldenPath (UCSC)PIM1  -  6p21.2   chr6:37137922-37143204 +  6p21.2   [Description]    (hg19-Feb_2009)
EnsemblPIM1 - 6p21.2 [CytoView]
Mapping of homologs : NCBIPIM1 [Mapview]
OMIM164960   
Gene and transcription
Genbank (Entrez)AK301158 AK301314 AK309347 BC020224 DA434260
RefSeq transcript (SRS)NM_001243186 NM_002648
RefSeq transcript (Entrez)NM_001243186 NM_002648
RefSeq genomic (SRS)AC_000138 NC_000006 NG_029601 NT_007592 NW_001838980
RefSeq genomic (Entrez)AC_000138 NC_000006 NG_029601 NT_007592 NW_001838980
Consensus coding sequences : CCDS (NCBI)PIM1
Cluster EST : UnigeneHs.81170 [ SRS ] Hs.81170 [ NCBI ]
Alternative Splicing : Fast-db (Paris)9481
Alternative Splicing GalleryENSG00000137193
Gene ExpressionPIM1 [ NCBI-GEO ]   PIM1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11309 (SRS) P11309 (Uniprot)
With graphics : InterProP11309
Splice isoforms : SwissVarP11309(Swissvar)
Domaine pattern : Prosite (SRS)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (SRS)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS    Ser/Thr_kinase_Pim-1   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS    Ser/Thr_kinase_Pim-1   
Related proteins : CluSTrP11309
Domain families : Pfam (SRS)Pkinase (PF00069)   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Blocks (Seattle)P11309
PDB (SRS)1XQZ    1XR1    1XWS    1YHS    1YI3    1YI4    1YWV    1YXS    1YXT    1YXU    1YXV    1YXX    2BIK    2BIL    2BZH    2BZI    2BZJ    2BZK    2C3I    2J2I    2O3P    2O63    2O64    2O65    2OBJ    2OI4    2XIX    2XIY    2XIZ    2XJ0    2XJ1    2XJ2    3A99    3BGP    3BGQ    3BGZ    3BWF    3C4E    3CXW    3CY2    3CY3    3DCV    3F2A    3JPV    3JXW    3JY0    3JYA    3MA3    3QF9    3R00    3R01    3R02    3R04    3T9I   
PDB (PDBSum)1XQZ    1XR1    1XWS    1YHS    1YI3    1YI4    1YWV    1YXS    1YXT    1YXU    1YXV    1YXX    2BIK    2BIL    2BZH    2BZI    2BZJ    2BZK    2C3I    2J2I    2O3P    2O63    2O64    2O65    2OBJ    2OI4    2XIX    2XIY    2XIZ    2XJ0    2XJ1    2XJ2    3A99    3BGP    3BGQ    3BGZ    3BWF    3C4E    3CXW    3CY2    3CY3    3DCV    3F2A    3JPV    3JXW    3JY0    3JYA    3MA3    3QF9    3R00    3R01    3R02    3R04    3T9I   
PDB (IMB)1XQZ    1XR1    1XWS    1YHS    1YI3    1YI4    1YWV    1YXS    1YXT    1YXU    1YXV    1YXX    2BIK    2BIL    2BZH    2BZI    2BZJ    2BZK    2C3I    2J2I    2O3P    2O63    2O64    2O65    2OBJ    2OI4    2XIX    2XIY    2XIZ    2XJ0    2XJ1    2XJ2    3A99    3BGP    3BGQ    3BGZ    3BWF    3C4E    3CXW    3CY2    3CY3    3DCV    3F2A    3JPV    3JXW    3JY0    3JYA    3MA3    3QF9    3R00    3R01    3R02    3R04    3T9I   
PDB (RSDB)1XQZ    1XR1    1XWS    1YHS    1YI3    1YI4    1YWV    1YXS    1YXT    1YXU    1YXV    1YXX    2BIK    2BIL    2BZH    2BZI    2BZJ    2BZK    2C3I    2J2I    2O3P    2O63    2O64    2O65    2OBJ    2OI4    2XIX    2XIY    2XIZ    2XJ0    2XJ1    2XJ2    3A99    3BGP    3BGQ    3BGZ    3BWF    3C4E    3CXW    3CY2    3CY3    3DCV    3F2A    3JPV    3JXW    3JY0    3JYA    3MA3    3QF9    3R00    3R01    3R02    3R04    3T9I   
Human Protein AtlasENSG00000137193
HPRD01292
IPIIPI00005014   IPI00745060   
Protein Interaction databases
DIP (DOE-UCLA)P11309
IntAct (EBI)P11309
FunCoupENSG00000137193
REACTOMEPIM1
BioGRIDPIM1
InParanoidP11309
Interologous Interaction database P11309
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PIM1
SNP (GeneSNP Utah)PIM1
SNP : HGBasePIM1
Genetic variants : HAPMAPPIM1
Cancer Gene: CensusPIM1 
Somatic Mutations in Cancer : COSMICPIM1 
CONAN: Copy Number AnalysisPIM1 
Mutations and Diseases : HGMDPIM1
OMIM164960   
GENETests164960   
Disease Genetic AssociationPIM1
Huge Navigator PIM1 [HugePedia]  PIM1 [HugeCancerGEM]
Genomic VariantsPIM1
snp3D : Map Gene to Disease5292
General knowledge
Homologs : HomoloGenePIM1
Homology/Alignments : Family Browser (UCSC)PIM1
Phylogenetic Trees/Animal Genes : TreeFamPIM1
Chemical/Protein Interactions : CTD5292
Chemical/Pharm GKB GenePA33318
Clinical trialPIM1
Cancer Resource (Charite)ENSG00000137193
Ontology : AmiGOnucleotide binding  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  plasma membrane  protein phosphorylation  cell cycle  multicellular organismal development  transcription factor binding  cell proliferation  manganese ion binding  positive regulation of cyclin-dependent protein kinase activity involved in G1/S  negative regulation of apoptotic process  negative regulation of sequence-specific DNA binding transcription factor activity  protein autophosphorylation  metal ion binding  
Ontology : EGO-EBInucleotide binding  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  plasma membrane  protein phosphorylation  cell cycle  multicellular organismal development  transcription factor binding  cell proliferation  manganese ion binding  positive regulation of cyclin-dependent protein kinase activity involved in G1/S  negative regulation of apoptotic process  negative regulation of sequence-specific DNA binding transcription factor activity  protein autophosphorylation  metal ion binding  
Pathways : KEGGJak-STAT signaling pathway
Other databases
Probes
Probes : ImagenesPIM1 Related clones (RZPD - Berlin)
Litterature
PubMed115 Pubmed reference(s) in Entrez
PubGenePIM1
iHOPPIM1

Bibliography

The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases.
Selten G, Cuypers HT, Boelens W, Robanus-Maandag E, Verbeek J, Domen J, van Beveren C, Berns A
Cell. 1986 ; 46 (4) : 603-611.
PMID 3015420
 
Cloning and characterization of the human PIM-1 gene: a putative oncogene related to the protein kinases.
Meeker TC, Nagarajan L, ar-Rushdi A, Croce CM
Journal of cellular biochemistry. 1987 ; 35 (2) : 105-112.
PMID 3429489
 
Pim-1 kinase stimulates c-Myc-mediated death signaling upstream of caspase-3 (CPP32)-like protease activation.
Mochizuki T, Kitanaka C, Noguchi K, Sugiyama A, Kagaya S, Chi S, Asai A, Kuchino Y
Oncogene. 1997 ; 15 (12) : 1471-1480.
PMID 9333023
 
Pim-1 kinase and p100 cooperate to enhance c-Myb activity.
Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA
Molecular cell. 1998 ; 2 (4) : 417-425.
PMID 9809063
 
Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway.
Mochizuki T, Kitanaka C, Noguchi K, Muramatsu T, Asai A, Kuchino Y
The Journal of biological chemistry. 1999 ; 274 (26) : 18659-18666.
PMID 10373478
 
Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.
Shirogane T, Fukada T, Muller JM, Shima DT, Hibi M, Hirano T
Immunity. 1999 ; 11 (6) : 709-719.
PMID 10626893
 
Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples.
Yoshida S, Kaneita Y, Aoki Y, Seto M, Mori S, Moriyama M
Oncogene. 1999 ; 18 (56) : 7994-7999.
PMID 10637510
 
Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1).
Koike N, Maita H, Taira T, Ariga H, Iguchi-Ariga SM
FEBS letters. 2000 ; 467 (1) : 17-21.
PMID 10664448
 
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Contributor(s)

Written08-2000Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL . PIM1 (pim-1 oncogene). Atlas Genet Cytogenet Oncol Haematol. August 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/PIM1ID261.html

This paper is referenced by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/37662/1/08-2000-PIM1ID261.pdf   [ Bibliographic record ]

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indexed on : Sat Apr 28 14:58:42 CEST 2012
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