SIRT1 is a member of the mammalian sirtuin genes that encode for seven protein lysine modifiers with deacetylase, ADP-ribosyltransferase and other deacylase activities. SIRT1 plays diverse roles in regulating cell proliferation, differentiation, stress response, metabolism, energy homeostasis, aging and cancer. Besides deacetylating histone substrates, SIRT1 regulates functions of an array of non-histone proteins including transcriptional factors for gene regulation, DNA repair machinery elements for reducing catastrophic genome lesions, epigenetic factors for chromatin and gene regulation, nuclear receptors and circadian clock as well as related factors for metabolism, and other cell signaling molecules. SIRT1 is involved in many types of human cancer.
NCBI: 23411 MIM: 604479 HGNC: 14929 Ensembl: ENSG00000096717
dbSNP: 23411 ClinVar: 23411 TCGA: ENSG00000096717 COSMIC: SIRT1
WenYong Chen
SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))
Atlas Genet Cytogenet Oncol Haematol. 2014-12-01
Online version: http://atlasgeneticsoncology.org/gene/44006/teaching-explorer/gene-fusions/?id=44006
2010-03-01 SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)) by Ruo-Chia Tseng,Yi-Ching Wan  Affiliation