email@example.com (JLH); UMR 1170 INSERM, Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif 94805, France (PHD)
Afadin, the protein coded by AFDN (6q27), also known as AF6 or MLLT4, is a cytoskeletal and junction-associated protein that links nectins, transmembrane proteins, to the F-actin (actin cytoskeleton) in a type of cell-cell junctions: the adherens junctions (AJs). Afadin plays an important role in AJs integrity and apical-basal polarity. There is growing evidence of its role in carcinogenesis.
Jean Loup Huret ; Philippe Dessen
AFDN (afadin, adherens junction formation factor)
Atlas Genet Cytogenet Oncol Haematol. 2018-12-01
Online version: http://atlasgeneticsoncology.org/gene/6/afdn-(afadin-adherens-junction-formation-factor)
1997-12-01 AFDN (afadin, adherens junction formation factor) by Jean-Loup Huret