Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

BCL6 (B-Cell Lymphoma 6)

Written1998-09Jean-Pierre Kerckaert
Unite 124 INSERM, Institut de Recherches sur le Cancer, Place de Verdun, 59045 Lille cedex, France
Updated2007-02Stevan Knezevich
BC Cancer Research Centre (BCCRC), Vancouver, British Columbia, Canada
Updated2012-12Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


Other aliasBCL5
LocusID (NCBI) 604
Atlas_Id 20
Location 3q27.3  [Link to chromosome band 3q27]
Location_base_pair Starts at and ends at bp from pter
Local_order Gene orientation: telomere - 5' BCL6 3' - centromere.
  BCL6 (3q27) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
  BCL6 (B-Cell Lymphoma 6) Hybridization with Vysis break apart probe (Abbott Molecular, US) showing BCL6 on 3q27.3 (red-green or a fused yellow signal) - Courtesy Adriana Zamecnikova.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARID4B (1q42.3) / BCL6 (3q27.3)BCL6 (3q27.3) / ADGRL2 (1p31.1)BCL6 (3q27.3) / AFDN (6q27)
BCL6 (3q27.3) / BCL2 (18q21.33)BCL6 (3q27.3) / BCL6 (3q27.3)BCL6 (3q27.3) / C3 (19p13.3)
BCL6 (3q27.3) / CIITA (16p13.13)BCL6 (3q27.3) / EIF4A2 (3q27.3)BCL6 (3q27.3) / FBXO18 (10p15.1)
BCL6 (3q27.3) / HIST1H4I (6p22.1)BCL6 (3q27.3) / HSP90AA1 (14q32.31)BCL6 (3q27.3) / HSP90AB1 (6p21.1)
BCL6 (3q27.3) / IKZF1 (7p12.2)BCL6 (3q27.3) / IL21R (16p12.1)BCL6 (3q27.3) / KCNN4 (19q13.31)
BCL6 (3q27.3) / LCP1 (13q14.13)BCL6 (3q27.3) / LONP1 (19p13.3)BCL6 (3q27.3) / MBNL1 (3q25.1)
BCL6 (3q27.3) / MYBL1 (8q13.1)BCL6 (3q27.3) / MYC (8q24.21)BCL6 (3q27.3) / NACA (12q13.3)
BCL6 (3q27.3) / PIM1 (6p21.2)BCL6 (3q27.3) / POU2AF1 (11q23.1)BCL6 (3q27.3) / RAF1 (3p25.2)
BCL6 (3q27.3) / RHOH (4p14)BCL6 (3q27.3) / SRSF3 (6p21.31)BCL6 (3q27.3) / TFRC (3q29)
BCL6 (3q27.3) / TOX4 (14q11.2)BCL6 (3q27.3) / TRBV20OR9-2 (-)CIITA (16p13.13) / BCL6 (3q27.3)
DMRT1 (9p24.3) / BCL6 (3q27.3)EIF4A2 (3q27.3) / BCL6 (3q27.3)FSTL3 (19p13.3) / BCL6 (3q27.3)
GAPDH (12p13.31) / BCL6 (3q27.3)GAS5 (1q25.1) / BCL6 (3q27.3)GRHPR (9p13.2) / BCL6 (3q27.3)
HIST1H4F (6p22.2) / BCL6 (3q27.3)HIST1H4I (6p22.1) / BCL6 (3q27.3)HRH4 (18q11.2) / BCL6 (3q27.3)
HSP90AA1 (14q32.31) / BCL6 (3q27.3)HSP90AA2P (11p14.1) / BCL6 (3q27.3)HSP90AB1 (6p21.1) / BCL6 (3q27.3)
IKZF1 (7p12.2) / BCL6 (3q27.3)IL21R (16p12.1) / BCL6 (3q27.3)JCHAIN (4q13.3) / BCL6 (3q27.3)
KCNN4 (19q13.31) / BCL6 (3q27.3)LCP1 (13q14.13) / BCL6 (3q27.3)LONP1 (19p13.3) / BCL6 (3q27.3)
LPP (3q28) / BCL6 (3q27.3)LRMP (12p12.1) / BCL6 (3q27.3)MBNL1 (3q25.1) / BCL6 (3q27.3)
MN1 (22q12.1) / BCL6 (3q27.3)MYC (8q24.21) / BCL6 (3q27.3)NACA (12q13.3) / BCL6 (3q27.3)
NAPA (19q13.32) / BCL6 (3q27.3)PIM1 (6p21.2) / BCL6 (3q27.3)POU2AF1 (11q23.1) / BCL6 (3q27.3)
RHOH (4p14) / BCL6 (3q27.3)SAA2-SAA4 (11p15.1) / BCL6 (3q27.3)SNHG5 (6q14.3) / BCL6 (3q27.3)
SRSF3 (6p21.31) / BCL6 (3q27.3)ST6GAL1 (3q27.3) / BCL6 (3q27.3)STAT5A (17q21.2) / BCL6 (3q27.3)
STPG1 (1p36.11) / BCL6 (3q27.3)TFRC (3q29) / BCL6 (3q27.3)TOX4 (14q11.2) / BCL6 (3q27.3)


Description The gene is encoded by 11 exons that are located on chromosome 3q27 and is 24,3 kb. The 5' portion encodes for the BTB/POZ domain (broad-complex/tramtrack/bric-a-brac/pox virus/zinc finger), while the 3' end encodes for 6 DNA binding zinc fingers. The first ATG occurs in exon 3.
Transcription 3,8 kb mRNA.


Description The protein product is 706 amino acids with an estimated molecular weight of 78,8 kDa.
Expression Normally expressed in germinal center B and T cells, other lymphoid tissues, in skeletal muscle cells and in keratinocytes. Normally expressed in germinal center B and T cells, other lymphoid tissues, in skeletal muscle cells and in keratinocytes.
Localisation Nuclear paraspeckles/dots.
Function Protein domains and functions
The protein can bind to sequence specific DNA and repress its transcription in addition to recruiting other protein repressors. The DNA binding is mediated through the consensus sequence TTCCT(A/C)GAA (see below), while the protein-protein interactions are mediated through the BTB/POZ domain and it has been shown to interact with other zinc finger proteins and corepressors (including Histone Deacetylase 1 (HDAC1) and NCOR2 (Silencing Mediator of Retinoid and Thryoid Receptor 1 (SMRT1))). The carboxy terminus, on the other hand, is responsible for sequence specific DNA binding through its 6 zinc fingers.

Consensus DNA motifs recognized by BCL6
The Zn fingers of BCL6 binds to DNA and recognizes specific DNA motifs: the M00424 motif, a consensus sequence for the NKX-homeobox family of transcription factors, the M2 motif, which mimics an M00424 half site; and the M0 motif (see details in Basso et al., 2010).

BCL6 cellular function
- BCL6 cellular function in germinal centers of lymph nodes follicles
Mature naïve B cells migrate from the bone marrow to lymphoid nodes, meet the antigen, they are stimulated to proliferate and further differentiate into centroblasts in germinal centers (GC) of lymphoid follicles. There, cells are subjects to somatic hypermutation and class switch recombination, to further differenciate into memory B cells or plasma cells. This process also requires the presence of follicular helper T cells. BCL6 has a major role in this process. In particular, BCL6 prevents ATM and TP53 (Phan et al., 2004) to induce apoptosis in response to DNA rearrangements such as those necessary for somatic hypermutation and class switch recombination processes. BCL6 is therefore essential for normal B cell development (reviews in Albagli-Curiel, 2003; Jardin et al., 2007; Parekh et al., 2008; Basso and Dalla-Favera, 2010; Pellicano and Holyoake, 2011; Wagner et al., 2011; Basso and Dalla-Favera, 2012; Okada et al., 2012).
- T follicular helper cells
BCL6 is essential for the development of follicular helper T (Tfh) cells. Tfh cells are defined by the expression of the surface markers CXCR5 and PD-1 and synthesis of IL4 and IL21. BCL6 upregulation of B cells in the outer follicle sustains their interactions with helper T cells and allows them to enter the germinal centers (GC) region (Poholek et al., 2010; Kitano et al., 2011; Baumjohann et al., 2011). ICOS induces BCL6, and BCL6 then induces CXCR5. Tfh cells were lost in the absence of B cells, demonstrating a B cell requirement for maintenance of BCL6 and Tfh cell commitment (Choi et al., 2011). BCL6 and MAF cooperate to induce Tfh cell differentiation (Kroenke et al., 2012).
- Other tissues
BCL6 promotes survival of olfactory sensory neurons (Otaki etal., 2010).
BCL6 associate to NACC1 in brain regions (Korutla et al., 2009).
BCL6 forms a complex with BCOR on the promoters of Notch target genes in Xenopus embryos (Sakano et al., 2010).
BCL6-overexpression inhibits osteoclastogenesis, and the PRDM1 (Blimp-1)/BCL6 balance is essential in regulating the bone homeostasis by controlling osteoclastogenesis (Miyauchi et al., 2010).
BCL6 controls the expression of the CC-type chemokine genes and attenuates allergic airway inflammation in pulmonary epithelium (Seto et al. 2011).

BCL6 repression activity
BCL6 binds to DNA as a homodimer and recruits co-repressor molecules, which, in turn, recruit class I and II histone deacetylases. BCL6 and histone deacetylases (HDACs) form stable complexes. BCL6 binds HDACs both directly through its C-terminal Zn fingers and through its N-terminal BTB/POZ domain and indirectly by recruiting several co-repressors such as BCOR, NCOR1, NCOR2 (which bind in a mutually exclusive way to the BTB/POZ domain), CTBP1 (which binds the BTB/POZ and the PEST domains), and MTA3 (which binds the PEST domain). Deacetylation of histones leads to transcriptional repression of BCL6 targets.
BCL6 interacts with ZBTB17 to repress CDKN1A and BCL2 (Phan et al., 2005). BCL6 has also been found to interact with other POK family members ((POZ and Krüppel)/ZBTB (zing finger and BTB) protein family) such as ZBTB7A (LRF) and ZBTB16 (PLZF).

BCL6 targets
An integrated biochemical and computational approach has recently identified thousands of BCL6 direct target genes, including B cell receptor (BCR; note: nothing to do with BCR, the partner of ABL1) and CD40 signaling genes (involved in signal transduction, MAPK activation, NF-AT activation, and NF-kB activation); T cell-mediated B-cell activation; apoptosis (BCL2, proteins involved in positive and negative regulation of the DISC complex and caspase activation, suggesting a role for BCL6 in balancing pro- and antiapoptotic programs in GC B cells); response to DNA damage (ATM, TP53, CDKN1A, ATR, CHEK1, TP53BP1...); interferon and cytokine signaling (interferon-type and interleukin receptors that lead to activation of JAK/STAT. STAT1, STAT3, and STAT5A were also found to be directly repressed by BCL6); Toll-like receptor signaling; TGFb receptor signaling; and WNT signaling (Basso et al., 2010).

BCL6 regulation
- B cell receptor
B cell receptor (BCR) induces BCL6 phosphorylation by MAPK1 on Ser333 and Ser343, which targets BCL-6 for rapid degradation by the ubiquitin/proteasome pathway (Niu et al., 1998). FBXO11 promotes BCL6 ubiquitylation and degradation (Duan et al., 2012).
- DNA damage
After DNA damage, the kinase ATM promotes BCL6 phosphorylation; follows an interaction with PIN1 required for BCL6 degradation (Phan et al., 2007).
- EP300
EP300 binds and acetylates BCL6, which inactivates BCL6 (acetylation disrupts the ability of BCL6 to recruit histone deacetylases). The same two pathways (HDAC pathway and SIRT2 pathway) that regulate acetylation-mediated activation of TP53 also control acetylation-mediated inactivation of BCL6 (Bereshchenko et al., 2002). BCL6 represses the expression of EP300 and its cofactor BAT3 (Cerchietti et al., 2010). EP300 acetylates and activates PAX5 (He et al., 2011), which enhances BCL6.
- Autoregulation
BCL6 protein binds BCL6 gene promoter, and repress BCL6, mechanism of negative autoregulation (Pasqualucci et al., 2003). PATZ1 interacts with BCL6 and is required for its negative autoregulation (Pero et al., 2012).
- CD40 signaling
CD40 signaling activates various pathways, including NF-kB, NF-AT, and AP-1 (Francis et al., 1995). ILF2 (NF45) and ILF3 (NF90) form the nuclear factor of activated T-cells (NF-AT), a crucial transcription factor essential for productive T cell activation (Kao et al., 1994). CD40 signalling reduces BCL6 expression, through induction of IRF4 by the NF-kB pathway (Saito et al., 2007).
- PRDM1 (review in Crotty et al., 2010)
JUND/AP-1 and activated STATs drive high BCL6 expression in GC B cells (Arguni et al., 2006). STAT5 up-regulates BCL6 expression (Scheeren et al., 2005); in contrast, STAT3 up-regulates PRDM1 (Diehl et al., 2008) (the protein coded from PRDM1 is named Blimp-1). BCL6 directly promotes the expression of BACH2, which repress PRDM1 (Blimp-1). BCL6 also suppresses PRDM1 (Blimp-1) through repression of IRF4. IRF4 binds to and induces PRDM1. PRDM1 (Blimp-1) abrogates BCL6. PAX5 (protein name: BSAP) contributes to BCL6 expression (Nera et al., 2006; Tarlinton, 2011). PAX5 abrogates PRDM1 (Blimp-1), which abrogates PAX5. BCL6 and PAX5 promote the expression of AICDA and UNG (which have a major role in somatic hypermutation and class-switch recombination) (Alinikula et al., 2011). BCL6 positively regulates AICDA, IRF8, and MYB via repression of MIR155 (Basso et al., 2012). BCL6 mediates transcriptional repression by recruiting HDACs. MIR155 directly targets HDAC4 and indirectly attenuates BCL6 expression (Sandhu et al., 2012). PRDM1 (Blimp-1) represses BCL6, and also PAX5, MYC, and AICDA (review in Martins and Calame, 2008). IRF8 is expressed at the high levels in germinal center (GC) B cells. IRF8 binds BCL6 promoter and activates BCL6 (Lee et al., 2006).
It is also to be noted that IRF4 is involved in the t(6;14)(p25;q32) IRF4/IGH. PRDM1 (Blimp-1) is inactivated in about 50% of the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (ABC- DLBCL) (Mandelbaum et al., 2010).

Homology BTB/POZ - Zinc Finger proteins (PLZF, HIC1, KUP, BAZF, ttk (drosophila), BrC (drosophila)...).


Note Chromosomal translocations involving BCL6 are found in 40% of diffuse large B-cell lymphomas (DLBCL), 5-10% of follicular lymphomas (FL), and 50% of nodular lymphocyte predominant Hodgkin lymphomas.
Mutations in the autoregulatory region of BCL6 leads to a constitutive BCL6 expression (Pasqualucci et al., 2003).
IRF4 response elements in the BCL6 gene mediate repression of BCL6. Mutations in the IRF4 repression region of BCL6 gene also leads to constitutive expression of BCL6 (Saito et al., 2007).
MYC, BCL2, and BCL6 rearrangements were detected in 6%, 15%, and 29% respectively of diffuse large B-cell lymphoma (DLBCL) patients. Double or triple rearrangements were detected in 3% of these patients. MYC rearrangement was associated with a significantly worse overall survival. BCL6 rearrangement also predicted a significantly shorter overall survival, especially for the non-GC phenotype (Akyurek et al., 2012).

Implicated in

Entity 3q27 rearrangements /NHL (non Hodgkin lymphomas)
Disease B cell non-Hodgkin Lymphoma (B-NHL)
Prognosis Generally considered to be a better prognosis if there is increased expression of BCL6. The mechanism by which its expression is increased does not seem to matter (ie different translocation partners increasing its expression results in the same prognosis).
Cytogenetics 3q27 rearrangements/aberrations are diverse and include: translocations, micro-deletions, point mutations and hypermutation. Approximately 50% of 3q27 translocations involves Ig genes at 14q32 (IgH), 2p12 (IgK) and 22q12 (IgL) (e.g. t(3;14)(q27;q32)). Less than half (~40%) include a variety of other chromosomal regions (1q21, 2q21, 4p11, 5q31, 6p21, 7p12, 8q24, 9p13, 11q13, 11q23, 12q11, 13q14-21, 14q11, 15q21; 16p11...). In addition, there are frequent bi-allelic alterations (translocation and deletion or mutation on the non-translocated allele).
Hybrid/Mutated Gene hybrid gene and transcripts are formed following promoter substitution between BCL6 and its different partners. Chimeric transcripts are generally detected containing the 5' part of the gene partner fused to the normal BCL6 exon 2 splice acceptor site. In some cases reciprocal chimeric transcripts driven by the 5' regulatory region of BCL6 fused to the partner gene coding region, have been characterised.
- t(1;3)(q25;q27) the gene in 1q25 is GAS5
- t(2;3)(p12;q27) the gene in 2p12 is IGK
- t(3;3)(q25;q27) the gene in 3q25 is MBNL1
- t(3;3)(q27;q27) the gene in 3q27 is ST6GAL1
- t(3;3)(q27;q27) the gene in 3q27 is EIF4A2
- t(3;3)(q27;q29) the gene in 3q29 is TFRC
- t(3;4)(q27;p13) the gene in 4p13 is RHOH
- t(3;6)(q27;p22) the gene in 6p22 is HIST1H4I
- t(3;6)(q27;p21) the gene in 6p21 is PIM1
- t(3;6)(q27;p21) the gene in 6p21 is SFRS3
- t(3;6)(q27;q15) the gene in 6q15 is SNHG5
- t(3;7)(q27;p12) the gene in 7p12 is IKZF1
- t(3;7)(q27;q32) the gene in 7q32 is FRA7H
- t(3;8)(q27;q24.1) the gene in 8q24.1 is MYC
- t(3;9)(q27;p24) the gene in 9p24 is DMRT1
- t(3;9)(q27;p11) the gene in 9p11 is GRHPR
- t(3;11)(q27;q23) the gene in 11q23 is POU2AF1
- t(3;12)(q27;p13) the gene in 12p13 is GAPDH
- t(3;12)(q27;q12) the gene in 12q12 is LRMP
- t(3;13)(q27;q14) the gene in 13q14 is LCP1
- t(3;14)(q27;q32) the gene in 14q32 is IGH
- t(3;14)(q27;q32) the gene in 14q32 is HSP90AA1
- t(3;16)(q27;p13) the gene in 16p13 is CIITA
- t(3;16)(q27;p11) the gene in 16p11 is IL21R
- t(3;19)(q27;q13) the gene in 19q13 is NAPA
- t(3;22)(q27;q11) the gene in 22q11 is IGL
Abnormal Protein No fusion protein.
Entity t(9;22)(q34;q11) leukemias
Disease BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition (Duy et al. 2011).
In chronic myelogenous leukemia (CML), BCL6 acts as a critical effector downstream of FoxO in self-renewal signaling of CML-initiating cells. Therefore, pharmacological inhibition of BCL6 may represent a novel strategy to eradicate leukemia-initiating cells in CML (Hurtz et al., 2011).
Entity Breast cancer
Disease BCL6 protein is elevated in human breast cancers, especially in high-grade, poorly differentiated and metastatic breast cancer cases (Bos et al., 2003; Logarajah et al., 2003; Brill et al., 2010). PRL (prolactin) rapidly suppressed BCL6. Loss of PRL-STAT5a signaling and concomitant upregulation of BCL6 may represent a regulatory switch facilitating undifferentiated histology and poor prognosis (Brill et al., 2010).
Entity Bladder transitional cell carcinoma
Disease BCL6 protein overexpression is observed in half of the cases of transitional cell carcinoma. However, BCL6 over-expression has a negative correlation with the histological grade (Cho et al., 2007).
Entity Soft tissue tumors
Disease BCL6 expression is more frequent in malignant compared with benign/uncertain solitary fibrous tumors, as well as in leiomyosarcomas compared with leiomyomas (Walters et al., 2011).
Entity Neuroblastoma
Disease In the neuroblastic phenotype of neuroblastoma, BCL6 expression is associated with increased time to relapse and increased overall survival (Chamdin et al., 2009).
Entity Gastric cancer
Disease In a study of 100 gastric cancer cases, BCL6 was highly expressed in differentiated cancers and reduced or absent in undifferentiated cancers. However, survival was identical in BCL6-positive and BCL6-negative cases (Hirata et al., 2009).
Entity Multiple myeloma
Disease IL6 induces transcriptional up-regulation of BCL6 via JAK/STAT3 pathway. TNF (TNF alpha) up-regulates BCL6. BCL6 expression is mediated independantly via both JAK/STAT3 and NF-KB pathways in multiple myeloma cells (Hideshima et al., 2010).


Note Clustered in a 3,3 kb EcoRI fragment (MTC) includind exon 1A and intron 1.


Prognostic significance of MYC, BCL2, and BCL6 rearrangements in patients with diffuse large B-cell lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab.
Akyurek N, Uner A, Benekli M, Barista I.
Cancer. 2012 Sep 1;118(17):4173-83. doi: 10.1002/cncr.27396. Epub 2011 Dec 27.
PMID 22213394
Ambivalent role of BCL6 in cell survival and transformation.
Albagli-Curiel O.
Oncogene. 2003 Jan 30;22(4):507-16.
PMID 12555064
Alternate pathways for Bcl6-mediated regulation of B cell to plasma cell differentiation.
Alinikula J, Nera KP, Junttila S, Lassila O.
Eur J Immunol. 2011 Aug;41(8):2404-13. doi: 10.1002/eji.201141553. Epub 2011 Jul 6.
PMID 21674482
JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells.
Arguni E, Arima M, Tsuruoka N, Sakamoto A, Hatano M, Tokuhisa T.
Int Immunol. 2006 Jul;18(7):1079-89. Epub 2006 May 15.
PMID 16702165
Roles of BCL6 in normal and transformed germinal center B cells.
Basso K, Dalla-Favera R.
Immunol Rev. 2012 May;247(1):172-83. doi: 10.1111/j.1600-065X.2012.01112.x.
PMID 22500840
Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells.
Basso K, Saito M, Sumazin P, Margolin AA, Wang K, Lim WK, Kitagawa Y, Schneider C, Alvarez MJ, Califano A, Dalla-Favera R.
Blood. 2010 Feb 4;115(5):975-84. doi: 10.1182/blood-2009-06-227017. Epub 2009 Dec 3.
PMID 19965633
BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.
Basso K, Schneider C, Shen Q, Holmes AB, Setty M, Leslie C, Dalla-Favera R.
J Exp Med. 2012 Dec 17;209(13):2455-65. doi: 10.1084/jem.20121387. Epub 2012 Nov 19.
PMID 23166356
Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development.
Baumjohann D, Okada T, Ansel KM.
J Immunol. 2011 Sep 1;187(5):2089-92. doi: 10.4049/jimmunol.1101393. Epub 2011 Jul 29.
PMID 21804014
Acetylation inactivates the transcriptional repressor BCL6.
Bereshchenko OR, Gu W, Dalla-Favera R.
Nat Genet. 2002 Dec;32(4):606-13. Epub 2002 Oct 28.
PMID 12402037
BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.
Cerchietti LC, Hatzi K, Caldas-Lopes E, Yang SN, Figueroa ME, Morin RD, Hirst M, Mendez L, Shaknovich R, Cole PA, Bhalla K, Gascoyne RD, Marra M, Chiosis G, Melnick A.
J Clin Invest. 2010 Nov 1. pii: 42869. doi: 10.1172/JCI42869. [Epub ahead of print]
PMID 21041953
Bcl6 is expressed in neuroblastoma: tumor cell type-specific expression predicts outcome.
Chamdin A, Jarzembowski JA, Subramanian C, Kuick R, Lee JS, Kwok RP, Castle VP, Opipari AW.
Transl Oncol. 2009 Aug 18;2(3):128-37.
PMID 19701497
High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma.
Chen YW, Hu XT, Liang AC, Au WY, So CC, Wong ML, Shen L, Tao Q, Chu KM, Kwong YL, Liang RH, Srivastava G.
Blood. 2006 Oct 1;108(7):2373-83. Epub 2006 Jun 13.
PMID 16772602
BCL6 gene mutations in transitional cell carcinomas.
Cho HY, Park HS, Lin Z, Kim I, Joo KJ, Cheon J.
J Int Med Res. 2007 Mar-Apr;35(2):224-30.
PMID 17542409
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6.
Choi YS, Kageyama R, Eto D, Escobar TC, Johnston RJ, Monticelli L, Lao C, Crotty S.
Immunity. 2011 Jun 24;34(6):932-46. doi: 10.1016/j.immuni.2011.03.023.
PMID 21636296
Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation.
Crotty S, Johnston RJ, Schoenberger SP.
Nat Immunol. 2010 Feb;11(2):114-20. doi: 10.1038/ni.1837. Epub 2010 Jan 19.
PMID 20084069
STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation.
Diehl SA, Schmidlin H, Nagasawa M, van Haren SD, Kwakkenbos MJ, Yasuda E, Beaumont T, Scheeren FA, Spits H.
J Immunol. 2008 Apr 1;180(7):4805-15.
PMID 18354204
FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas.
Duan S, Cermak L, Pagan JK, Rossi M, Martinengo C, di Celle PF, Chapuy B, Shipp M, Chiarle R, Pagano M.
Nature. 2012 Jan 5;481(7379):90-3. doi: 10.1038/nature10688.
PMID 22113614
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition.
Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon SM, Nahar R, Braig M, Park E, Kim YM, Hofmann WK, Herzog S, Jumaa H, Koeffler HP, Yu JJ, Heisterkamp N, Graeber TG, Wu H, Ye BH, Melnick A, Muschen M.
Nature. 2011 May 19;473(7347):384-8. doi: 10.1038/nature09883.
PMID 21593872
Induction of the transcription factors NF-kappa B, AP-1 and NF-AT during B cell stimulation through the CD40 receptor.
Francis DA, Karras JG, Ke XY, Sen R, Rothstein TL.
Int Immunol. 1995 Feb;7(2):151-61.
PMID 7537532
Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity.
He T, Hong SY, Huang L, Xue W, Yu Z, Kwon H, Kirk M, Ding SJ, Su K, Zhang Z.
J Biol Chem. 2011 Apr 22;286(16):14137-45. doi: 10.1074/jbc.M110.176289. Epub 2011 Feb 25.
PMID 21357426
A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells.
Hideshima T, Mitsiades C, Ikeda H, Chauhan D, Raje N, Gorgun G, Hideshima H, Munshi NC, Richardson PG, Carrasco DR, Anderson KC.
Blood. 2010 May 6;115(18):3772-5. doi: 10.1182/blood-2010-02-270082. Epub 2010 Mar 12.
PMID 20228272
BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers.
Hirata Y, Ogasawara N, Sasaki M, Mizushima T, Shimura T, Mizoshita T, Mori Y, Kubota E, Wada T, Tanida S, Kataoka H, Kamiya T, Higashiyama S, Joh T.
Br J Cancer. 2009 Apr 21;100(8):1320-9. doi: 10.1038/sj.bjc.6605010. Epub 2009 Mar 31.
PMID 19337254
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia.
Hurtz C, Hatzi K, Cerchietti L, Braig M, Park E, Kim YM, Herzog S, Ramezani-Rad P, Jumaa H, Muller MC, Hofmann WK, Hochhaus A, Ye BH, Agarwal A, Druker BJ, Shah NP, Melnick AM, Muschen M.
J Exp Med. 2011 Oct 24;208(11):2163-74. doi: 10.1084/jem.20110304. Epub 2011 Sep 12.
PMID 21911423
Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90.
Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthesy B.
J Biol Chem. 1994 Aug 12;269(32):20691-9.
PMID 7519613
Intrachromosomal rearrangement of chromosome 3q27: an under recognized mechanism of BCL6 translocation in B-cell non-Hodgkin lymphoma.
Keller CE, Nandula S, Vakiani E, Alobeid B, Murty VV, Bhagat G.
Hum Pathol. 2006 Aug;37(8):1093-9. Epub 2006 Jun 21.
PMID 16867873
LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas.
Kerckaert JP, Deweindt C, Tilly H, Quief S, Lecocq G, Bastard C.
Nat Genet. 1993 Sep;5(1):66-70.
PMID 8220427
Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity.
Kitano M, Moriyama S, Ando Y, Hikida M, Mori Y, Kurosaki T, Okada T.
Immunity. 2011 Jun 24;34(6):961-72. doi: 10.1016/j.immuni.2011.03.025.
PMID 21636294
NAC1, a POZ/BTB protein that functions as a corepressor.
Korutla L, Wang P, Jackson TG, Mackler SA.
Neurochem Int. 2009 Mar-Apr;54(3-4):245-52. doi: 10.1016/j.neuint.2008.12.008. Epub 2008 Dec 13.
PMID 19121354
Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation.
Kroenke MA, Eto D, Locci M, Cho M, Davidson T, Haddad EK, Crotty S.
J Immunol. 2012 Apr 15;188(8):3734-44. doi: 10.4049/jimmunol.1103246. Epub 2012 Mar 16.
PMID 22427637
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein.
Lee CH, Melchers M, Wang H, Torrey TA, Slota R, Qi CF, Kim JY, Lugar P, Kong HJ, Farrington L, van der Zouwen B, Zhou JX, Lougaris V, Lipsky PE, Grammer AC, Morse HC 3rd.
J Exp Med. 2006 Jan 23;203(1):63-72. Epub 2005 Dec 27.
PMID 16380510
BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation.
Logarajah S, Hunter P, Kraman M, Steele D, Lakhani S, Bobrow L, Venkitaraman A, Wagner S.
Oncogene. 2003 Aug 28;22(36):5572-8.
PMID 12944904
BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma.
Mandelbaum J, Bhagat G, Tang H, Mo T, Brahmachary M, Shen Q, Chadburn A, Rajewsky K, Tarakhovsky A, Pasqualucci L, Dalla-Favera R.
Cancer Cell. 2010 Dec 14;18(6):568-79. doi: 10.1016/j.ccr.2010.10.030.
PMID 21156281
Regulation and functions of Blimp-1 in T and B lymphocytes.
Martins G, Calame K.
Annu Rev Immunol. 2008;26:133-69. doi: 10.1146/annurev.immunol.26.021607.090241.
PMID 18370921
Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein.
Miki T, Kawamata N, Hirosawa S, Aoki N.
Blood. 1994 Jan 1;83(1):26-32.
PMID 8274740
The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.
Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T.
J Exp Med. 2010 Apr 12;207(4):751-62. doi: 10.1084/jem.20091957. Epub 2010 Apr 5.
PMID 20368579
Loss of Pax5 promotes plasma cell differentiation.
Nera KP, Kohonen P, Narvi E, Peippo A, Mustonen L, Terho P, Koskela K, Buerstedde JM, Lassila O.
Immunity. 2006 Mar;24(3):283-93.
PMID 16546097
Prognostic impact of chromosomal alteration of 3q27 on nodal B-cell lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 329 consecutive patients.
Niitsu N, Okamoto M, Nakamura N, Nakamine H, Aoki S, Hirano M, Miura I.
Leuk Res. 2007 Sep;31(9):1191-7. Epub 2007 Jan 2.
PMID 17197022
Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor.
Niu H, Ye BH, Dalla-Favera R.
Genes Dev. 1998 Jul 1;12(13):1953-61.
PMID 9649500
Pathogenetic and clinical implications of non-immunoglobulin ; BCL6 translocations in B-cell non-Hodgkin's lymphoma.
Ohno H.
J Clin Exp Hematop. 2006 Nov;46(2):43-53.
PMID 17142954
Differentiation of germinal center B cells and follicular helper T cells as viewed by tracking Bcl6 expression dynamics.
Okada T, Moriyama S, Kitano M.
Immunol Rev. 2012 May;247(1):120-32. doi: 10.1111/j.1600-065X.2012.01120.x.
PMID 22500836
The proto-oncogene BCL6 promotes survival of olfactory sensory neurons.
Otaki JM, Hatano M, Matayoshi R, Tokuhisa T, Yamamoto H.
Dev Neurobiol. 2010 May;70(6):424-35. doi: 10.1002/dneu.20786.
PMID 20151461
Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas.
Parekh S, Prive G, Melnick A.
Leuk Lymphoma. 2008 May;49(5):874-82. doi: 10.1080/10428190801895345.
PMID 18452090
Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma.
Pasqualucci L, Migliazza A, Basso K, Houldsworth J, Chaganti RS, Dalla-Favera R.
Blood. 2003 Apr 15;101(8):2914-23. Epub 2002 Dec 19.
PMID 12515714
Assembling defenses against therapy-resistant leukemic stem cells: Bcl6 joins the ranks.
Pellicano F, Holyoake TL.
J Exp Med. 2011 Oct 24;208(11):2155-8. doi: 10.1084/jem.20112087.
PMID 22025499
POZ-, AT-hook-, and zinc finger-containing protein (PATZ) interacts with human oncogene B cell lymphoma 6 (BCL6) and is required for its negative autoregulation.
Pero R, Palmieri D, Angrisano T, Valentino T, Federico A, Franco R, Lembo F, Klein-Szanto AJ, Del Vecchio L, Montanaro D, Keller S, Arra C, Papadopoulou V, Wagner SD, Croce CM, Fusco A, Chiariotti L, Fedele M.
J Biol Chem. 2012 May 25;287(22):18308-17. doi: 10.1074/jbc.M112.346270. Epub 2012 Apr 9.
PMID 22493480
The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells.
Phan RT, Dalla-Favera R.
Nature. 2004 Dec 2;432(7017):635-9.
PMID 15577913
Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.
Phan RT, Saito M, Kitagawa Y, Means AR, Dalla-Favera R.
Nat Immunol. 2007 Oct;8(10):1132-9. Epub 2007 Sep 9.
PMID 17828269
In vivo regulation of Bcl6 and T follicular helper cell development.
Poholek AC, Hansen K, Hernandez SG, Eto D, Chandele A, Weinstein JS, Dong X, Odegard JM, Kaech SM, Dent AL, Crotty S, Craft J.
J Immunol. 2010 Jul 1;185(1):313-26. doi: 10.4049/jimmunol.0904023. Epub 2010 Jun 2.
PMID 20519643
A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.
Saito M, Gao J, Basso K, Kitagawa Y, Smith PM, Bhagat G, Pernis A, Pasqualucci L, Dalla-Favera R.
Cancer Cell. 2007 Sep;12(3):280-92.
PMID 17785208
BCL6 canalizes Notch-dependent transcription, excluding Mastermind-like1 from selected target genes during left-right patterning.
Sakano D, Kato A, Parikh N, McKnight K, Terry D, Stefanovic B, Kato Y.
Dev Cell. 2010 Mar 16;18(3):450-62. doi: 10.1016/j.devcel.2009.12.023.
PMID 20230751
STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression.
Scheeren FA, Naspetti M, Diehl S, Schotte R, Nagasawa M, Wijnands E, Gimeno R, Vyth-Dreese FA, Blom B, Spits H.
Nat Immunol. 2005 Mar;6(3):303-13. Epub 2005 Feb 13.
PMID 15711548
Bcl6 in pulmonary epithelium coordinately controls the expression of the CC-type chemokine genes and attenuates allergic airway inflammation.
Seto T, Yoshitake M, Ogasawara T, Ikari J, Sakamoto A, Hatano M, Hirata H, Fukuda T, Kuriyama T, Tatsumi K, Tokuhisa T, Arima M.
Clin Exp Allergy. 2011 Nov;41(11):1568-78. doi: 10.1111/j.1365-2222.2011.03836.x. Epub 2011 Aug 1.
PMID 21801248
A novel t(2;3)(p11;q27) in a case of follicular lymphoma.
Tapinassi C, Micucci C, Lahortiga I, Malazzi O, Gasparini P, Gorosquieta A, Odero MD, Belloni E.
Cancer Genet Cytogenet. 2007 Jan 1;172(1):70-3.
PMID 17175383
Bcl6: where too much complexity is barely enough.
Tarlinton DM.
Eur J Immunol. 2011 Aug;41(8):2148-51. doi: 10.1002/eji.201141891.
PMID 21792874
Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism.
Tran TH, Utama FE, Lin J, Yang N, Sjolund AB, Ryder A, Johnson KJ, Neilson LM, Liu C, Brill KL, Rosenberg AL, Witkiewicz AK, Rui H.
Cancer Res. 2010 Feb 15;70(4):1711-21. doi: 10.1158/0008-5472.CAN-09-2314. Epub 2010 Feb 2.
PMID 20124477
The role of BCL6 in lymphomas and routes to therapy.
Wagner SD, Ahearne M, Ko Ferrigno P.
Br J Haematol. 2011 Jan;152(1):3-12. doi: 10.1111/j.1365-2141.2010.08420.x. Epub 2010 Nov 18.
PMID 21083654
BCL-6 expression in mesenchymal tumours: an immunohistochemical and fluorescence in situ hybridisation study.
Walters MP, McPhail ED, Law ME, Folpe AL.
J Clin Pathol. 2011 Oct;64(10):866-9. doi: 10.1136/jclinpath-2011-200185. Epub 2011 Jul 1.
PMID 21725042
A novel t(3;8)(q27;q24.1) simultaneously involving both the BCL6 and MYC genes in a diffuse large B-cell lymphoma.
Wang HY, Bossler AD, Schaffer A, Tomczak E, DiPatri D, Frank DM, Nowell PC, Bagg A.
Cancer Genet Cytogenet. 2007 Jan 1;172(1):45-53.
PMID 17175379
Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma.
Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R.
Science. 1993 Oct 29;262(5134):747-50.
PMID 8235596


This paper should be referenced as such :
Huret, JL
BCL6 (B-Cell Lymphoma 6)
Atlas Genet Cytogenet Oncol Haematol. 2013;17(6):371-379.
Free journal version : [ pdf ]   [ DOI ]
On line version :
History of this paper:
Kerkaert, JP. LAZ3 (lymphoma associated zinc finger on chromosome 3). Atlas Genet Cytogenet Oncol Haematol. 1999;3(1):4-5.
Knezevich, S. BCL6 (B-Cell Lymphoma 6). Atlas Genet Cytogenet Oncol Haematol. 2007;11(3):177-179.

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 119 ]
  3q27 rearrangements (BCL6) in non Hodgkin lymphoma::t(3;Var)(q27;Var) in non Hodgkin lymphoma
Double Hit Lymphoma (DHL)::Triple Hit Lymphoma (THL)
t(1;3)(q25;q27) GAS5/BCL6
t(3;3)(q25;q27) MBNL1/BCL6
t(3;3)(q27;q27) ST6GAL1/BCL6::del(3)(q27q27) ST6GAL1/BCL6
t(3;3)(q27;q28) EIF4A2/BCL6
t(3;3)(q27;q29) TFRC/BCL6
t(3;6)(q27;p21) SRSF3/BCL6
t(3;6)(q27;p21) PIM1/BCL6
t(3;6)(q27;p22) HIST1H4I/BCL6
t(3;6)(q27;q14) SNHG5/BCL6
t(3;6)(q27;q15) ?/BCL6
t(3;7)(q27;p12) IKZF1/BCL6
t(3;7)(q27;q32) MIR29A/BCL6
t(3;7)(q27;q32) FRA7H/BCL6
t(3;8)(q27;q24) BCL6/MYC
t(3;9)(q27;p13) GRHPR/BCL6
t(3;9)(q27;p24) DMRT1/BCL6
t(3;11)(q27;q23) POU2AF1/BCL6
t(3;12)(q27;p12) LRMP/BCL6
t(3;12)(q27;p13) GAPDH/BCL6
t(3;13)(q27;q14) LCP1/BCL6
t(3;14)(q27;q32) HSP90AA1/BCL6
t(3;16)(q27;p11) IL21R/BCL6
t(3;16)(q27;p13) CIITA/BCL6
t(3;19)(q27;q13) NAPA/BCL6
t(3;14)(q27;q32) IGH/BCL6::t(2;3)(p12;q27) IGK/BCL6::t(3;22)(q27;q11) IGL/BCL6
t(3;4)(q27;p13) RHOH/BCL6
del(3)(q27):del(3)(q27q28) LPP/BCL6
del(3)(q27q28) LPP/BCL6
inv(3)(q25q27) BCL6/MBNL1
t(2;3)(p11;q27) IGK/BCL6
EIF4A2/BCL6 (3q27)
t(3;3)(q29;q27) TFRC/BCL6
t(3;4)(q27;p14) RHOH/BCL6
t(3;6)(q27;p21) BCL6/PIM1
t(3;8)(q27;q13) BCL6/MYBL1
t(3;10)(q27;p15) BCL6/FBXO18
t(3;13)(q27;q14) BCL6/LCP1
t(3;14)(q27;q32):t(3;8;14)(q27;q24;q32) IGH/BCL6
t(3;14)(q27;q32) IGH/BCL6
t(3;16)(q27;p12) IL21R/BCL6
t(3;16)(q27;p13) BCL6/CIITA
t(3;19)(q27;p13) BCL6/C3
3q27 rearrangements (BCL6) in non Hodgkin lymphoma::t(3;Var)(q27;Var) in non Hodgkin lymphoma
Classification of B-cell non-Hodgkin lymphomas (NHL)
Centroblastic lymphoma
Primary cutaneous DLBCL, leg type
Germinal center B-cell-like diffuse Large B-cell Lymphoma (GCB) DLBCL
Double Hit Lymphoma (DHL)::Triple Hit Lymphoma (THL)
EBV positive DLBCL, NOS
Follicular lymphoma (FL)
Hodgkin lymphoma
i(3)(q10) in non-Hodgkin's lymphoma (NHL)
Immunoblastic lymphoma
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma
inv(16)(p13q24) CBFA2T3/GLIS2
HIV-associated lymphomas
Mucosa-associated lymphoid tissue (MALT) lymphoma
Marginal Zone B-cell lymphoma
Monomorphic PTLD (B- and T/NK-cell types)
Nodular lymphocyte-predominant Hodgkin lymphoma
Pediatric-type Follicular Lymphoma
Polymorphic PTLD
Primary mediastinal B-cell lymphoma (PMBL)
t(1;1)(p36;q21) in Non Hodgkin Lymphoma
t(1;3)(q25;q27) GAS5/BCL6
t(2;14)(p13-16;q32) IGH/BCL11A
t(3;3)(q25;q27) MBNL1/BCL6
t(3;3)(q27;q27) ST6GAL1/BCL6::del(3)(q27q27) ST6GAL1/BCL6
t(3;3)(q27;q28) EIF4A2/BCL6
t(3;3)(q27;q29) TFRC/BCL6
t(3;6)(q27;p21) SRSF3/BCL6
t(3;6)(q27;p21) PIM1/BCL6
t(3;6)(q27;p22) HIST1H4I/BCL6
t(3;6)(q27;q14) SNHG5/BCL6
t(3;6)(q27;q15) ?/BCL6
t(3;7)(q27;p12) IKZF1/BCL6
t(3;7)(q27;q32) MIR29A/BCL6
t(3;7)(q27;q32) FRA7H/BCL6
t(3;8)(q27;q24) BCL6/MYC
t(3;9)(q27;p13) GRHPR/BCL6
t(3;9)(q27;p24) DMRT1/BCL6
t(3;11)(q27;q23) POU2AF1/BCL6
t(3;12)(q27;p12) LRMP/BCL6
t(3;12)(q27;p13) GAPDH/BCL6
t(3;13)(q27;q14) LCP1/BCL6
t(3;14)(q27;q32) HSP90AA1/BCL6
t(3;16)(q27;p11) IL21R/BCL6
t(3;16)(q27;p13) CIITA/BCL6
t(3;19)(q27;q13) NAPA/BCL6
t(9;17)(p13;p12) PAX5/NCOR1
t(X;17)(p11;q21) BCOR/RARA
t(14;15)(q32;q11) IGH/NBEAP1
t(14;16)(q32;q23) IGH/MAF
t(3;14)(q27;q32) IGH/BCL6::t(2;3)(p12;q27) IGK/BCL6::t(3;22)(q27;q11) IGL/BCL6
t(3;4)(q27;p13) RHOH/BCL6
t(2;6)(p12;p25) IRF4/IGK::t(6;14)(p25;q32) IRF4/IGH::t(6;22)(p25;q11) IRF4/IGL
T-cell/histiocyte rich large B-cell lymphoma
del(3)(q27):del(3)(q27q28) LPP/BCL6
del(3)(q27q28) LPP/BCL6
inv(3)(q25q27) BCL6/MBNL1
t(2;3)(p11;q27) IGK/BCL6
EIF4A2/BCL6 (3q27)
t(3;3)(q29;q27) TFRC/BCL6
t(3;4)(q27;p14) RHOH/BCL6
t(3;6)(q27;p21) BCL6/PIM1
t(3;8)(q27;q13) BCL6/MYBL1
t(3;10)(q27;p15) BCL6/FBXO18
t(3;13)(q27;q14) BCL6/LCP1
t(3;14)(q27;q32):t(3;8;14)(q27;q24;q32) IGH/BCL6
t(3;14)(q27;q32) IGH/BCL6
t(3;16)(q27;p12) IL21R/BCL6
t(3;16)(q27;p13) BCL6/CIITA
t(3;19)(q27;p13) BCL6/C3
Histiocyte-rich B-cell lymphoma

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Bone: Sarcoma with inv(X)(p11.4p11.22) BCOR/CCNB3
Head and Neck: Oral squamous cell carcinoma
t(3;3)(p25;q27) BCL6/RAF1
t(3;14)(q27;q32) IGH/BCL6

External links

Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)604
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
canSAR (ICR) (select the gene name)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Oct 18 17:29:39 CEST 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us