Clinic for Hematology, Oncology, Immunology and Center for Tumor Biology and Immunology, Philipps University Marburg, Germany \\\/ frechm@staff.uni-marburg.de, neubauer@staff.uni-marburg.de
SKI gene is located on chromosome 1 (1p36.33-p36.32) and encodes a predominantly nuclear co-regulator of several transcription factors. SKI is also a proto-oncogene. SKI was initially found as the viral protein v-Ski of the Sloan-Kettering viruses, which are able to transform avian cells in vitro. SKI is a well described inhibitor of TGFβ signalling and is further involved in essential cellular mechanisms like proliferation and differentiation. As an oncogene SKI is further overexpressed in various tumours promoting transformation and tumour progression, but in some tumours SKI is also described as a tumour suppressor.
NCBI: 6497 MIM: 164780 HGNC: 10896 Ensembl: ENSG00000157933
dbSNP: 6497 ClinVar: 6497 TCGA: ENSG00000157933 COSMIC: SKI
Miriam Frech ; Andreas Neubauer
SKI (SKI proto-oncogene)
Atlas Genet Cytogenet Oncol Haematol. 2021-02-01
Online version: http://atlasgeneticsoncology.org/gene/42303/haematological-explorer/img/img/logo-atlas-4.svg