Clinic for Hematology, Oncology, Immunology and Center for Tumor Biology and Immunology, Philipps University Marburg, Germany \\\/ firstname.lastname@example.org, email@example.com
SKI gene is located on chromosome 1 (1p36.33-p36.32) and encodes a predominantly nuclear co-regulator of several transcription factors. SKI is also a proto-oncogene. SKI was initially found as the viral protein v-Ski of the Sloan-Kettering viruses, which are able to transform avian cells in vitro. SKI is a well described inhibitor of TGFβ signalling and is further involved in essential cellular mechanisms like proliferation and differentiation. As an oncogene SKI is further overexpressed in various tumours promoting transformation and tumour progression, but in some tumours SKI is also described as a tumour suppressor.
Miriam Frech ; Andreas Neubauer
SKI (SKI proto-oncogene)
Atlas Genet Cytogenet Oncol Haematol. 2021-02-01
Online version: http://atlasgeneticsoncology.org/gene/42303/ski-(ski-proto-oncogene)