Written | 2014-04 | Norimitsu Inoue, Takashi Akazawa |
Department of Molecular Genetics, Osaka Medical Center for Cancer, Cardiovascular Diseases, Osaka, Osaka 537-8511, Japan |
This article is an update of : |
2011-01 | Norimitsu Inoue, Takashi Akazawa | |
Department of Molecular Genetics, Osaka Medical Center for Cancer, Cardiovascular Diseases, Osaka, Osaka 537-8511, Japan |
Abstract | Interleukin-17A (IL17A), a characteristic cytokine produced by the T helper 17 cells (Th17 cells), can form either a homodimer or a heterodimer with IL17F. It is produced not only by Th17 cells, but also by cytotoxic CD8+ T cells (Tc17 cells), γδ T cells, invariant natural killer T cells (iNKT cells), lymphoid tissue inducer cells (LTi cells), and other hematopoietic and non-hematopoietic cells. During development, these cells exhibit flexible or plastic features distinct from those of Th1 and Th2 cells. IL17A plays important roles in the pathogenesis of autoimmune diseases and in the host defenses against bacterial and fungal infections. Expression of IL17A and its related factors, as well as the infiltration of IL17A-producing cells into the tumor microenvironment, has been implicated in anti-tumor or pro-tumor effects in various cancers. |
Keywords | Th17 cells, RORγt, STAT3, IL23, TGFβ, inflammation |
Identity |
Alias (NCBI) | CTLA8 | IL-17 | IL-17A | IL17 |
HGNC (Hugo) | IL17A |
HGNC Alias symb | IL-17A | IL-17 |
HGNC Alias name | cytotoxic T-lymphocyte-associated protein 8 |
HGNC Previous name | CTLA8 | IL17 |
HGNC Previous name | interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) |
LocusID (NCBI) | 3605 |
Atlas_Id | 40945 |
Location | 6p12.2 [Link to chromosome band 6p12] |
Location_base_pair | Starts at 52186375 and ends at 52190638 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping IL17A.png] |
Local_order | pter - PKHD1 (polycystic kidney and hepatic diseases 1) - MIR206 (microRNA 206) - MIR133B (microRNA 133b) - IL17A - IL17F (interleukin 17F) - SLC25A20P1 (solute carrier family 25, member 20 pseudogene 1) - MCM3 (minichromosome maintenance complex component 3) - centromere. |
Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
DNA/RNA |
Note | IL17A was initially identified in a subtractive hybridization screen of a rodent T cell library as mouse cytotoxic T lymphocyte-associated antigen 8 (mCTLA8) (Rouvier et al., 1993), but is now recognized as a characteristic cytokine of the Th17 cell subset, which has effector functions distinct from those of Th1 and Th2 cells (Korn et al., 2009; Kurebayashi et al., 2013). |
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IL17A gene. The IL17A gene spans a region of 4252 bp, consisting of three exons (untranslated region (UTR), light blue; coding region, blue) and two introns (brown). Exons 1, 2, and 3 are 72 bp (45 bp 5' UTR plus 27 bp coding region), 203 bp (all coding regions), and 1584 bp (238 bp coding region plus 1346 bp 3' UTR) in length, respectively. The two introns are 1144 bp and 1249 bp in length. | |
Description | The IL17A gene spans a region of 4252 bp, consisting of three exons. |
Transcription | The transcript is 1859 bp and has a 45 bp 5' UTR, a 468 bp coding sequence, and a 1346 bp 3' UTR. |
Pseudogene | No pseudogenes homologous to this gene exist elsewhere in the genome. |
Protein |
Note | The IL17A protein is a glycoprotein that can form either a disulfide-linked homodimer or a heterodimer with the IL17F protein. Members of the IL17 protein family (IL17A-F) contain four highly conserved cysteine residues on each monomer (Kolls and Lindén, 2004; Iwakura et al., 2011). Structural analysis of the IL17F protein has revealed that these four cysteines participate in the characteristic cystine-knot formation observed in other growth factors such as nerve growth factor (NGF), transforming growth factor β2 (TGFβ2) and platelet-derived growth factor (PDGF)-BB (McDonald and Hendrickson, 1993), although one of the canonical disulfides of the cystine-knot is absent from the IL17 protein family (Hymowitz et al., 2001). Two additional cysteine residues participate in homodimer formation via inter-chain disulfide bonds. Crystal structures are now available for IL17A in complex with an antibody (Gerhardt et al., 2009), an IL17F/IL17 receptor A complex (Ely et al., 2009) and an IL17A/IL17 receptor A complex (Liu et al., 2013). |
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IL17A protein. The IL17A protein (155 amino acids) consists of a signal peptide (light green, 23 amino acids) and a mature peptide (green, 132 amino acids). Four conserved cysteines (Cys) form the intra-chain disulfide bonds indicated by black lines (Cys94/Cys144 and Cys99/Cys146) (Hymowitz et al., 2001). The two cysteines indicated by asterisks (Cys33 and Cys129) participate in homodimer formation via inter-chain disulfide bonds. Asparagine 68 (Asn68, black circle) is predicted to be glycosylated. | |
Description | The IL17A monomer is a peptide consisting of 155 amino acids. The IL17A peptide comprises a 23 amino acid signal peptide and a 132 amino acid mature peptide. The IL17A homodimer has a molecular weight of 35 kD (Kolls and Lindén, 2004). |
Expression | IL17A is secreted not only by CD4+ T cells (Th17 cells), which also produce IL17F, IL21, and IL22 (Korn et al., 2009; Kurebayashi et al., 2013), but also by CD8+ T cells (Tc17 cells), γδ T cells, invariant natural killer T cells (iNKT cells), innate lymphoid cells (ILCs) including lymphoid tissue inducer cells (LTi cells), B cells, neutrophils, and other non-hematopoietic cells (Cua and Tato, 2010). These lymphocytes all express the retinoic acid receptor-related orphan nuclear receptor C (RORC, the human analogue of mouse RORγt, a splice variant of the Rorc gene). RORγt is essential for IL17A production and the development of IL17A-producing cells, at least in lymphocytes, and is thus considered a master regulator of IL17A-producing cells. Th17 cells Tc17 cells γδ T cells iNKT cells LTi cells B cells Other cells |
Localisation | IL17A is a secreted protein. |
Function | IL17A is a pro-inflammatory cytokine that acts on a variety of cells (e.g., fibroblasts, epithelial cells, endothelial cells, and monocytes) to induce the production of other cytokines, including IL6, tumor necrosis factor-α (TNFα), granulocyte-macrophage colony-stimulating-factor (GMCSF), granulocyte colony-stimulating-factor (GCSF), chemokines (chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL2, CXCL5, and CXCL8), antimicrobial peptides (defensins) and matrix metalloproteinases (MMP1, MMP3, and MMP13) (Eyerich et al., 2010; Iwakura et al., 2011). These factors mediate the recruitment, activation and migration of neutrophils and myeloid cells, and also induce angiogenesis and tissue destruction. IL17A, IL17F, and the IL17A-IL17F heterodimer bind to a heteromeric receptor complex composed of IL17 receptor A (IL17RA) and IL17 receptor C (IL17RC). IL17RA is expressed at high levels in hematopoietic cells and at low levels in epithelial cells, fibroblasts, and endothelial cells (Gaffen, 2009; Iwakura et al., 2011). On the other hand, IL17RC is expressed at low levels in hematopoietic cells and at high levels in the adrenal gland, prostate, liver, and thyroid. IL17RA has higher affinity for IL17A than IL17F, whereas IL17RC has higher affinity for IL17F than IL17A. Although cytokines secreted by most activated helper T cells generally stimulate the Janus kinase (JAK)/STAT pathway, the IL17-family cytokines stimulate signaling pathways involved in the innate immune system, such as the TLR signaling pathway (Gaffen, 2009; Iwakura et al., 2011). IL17 receptors contain a conserved domain, 'similar expression to fibroblast growth factor/IL17R' (SEFIR), in the cytoplasmic region. This domain is similar to the Toll-/IL1R (TIR) domain (Gaffen, 2009; Iwakura et al., 2011). When the IL17 receptor is activated, the adaptor molecule actin-related gene 1 (ACT1, a U-box E3 ubiquitin ligase) is recruited to the SEFIR domain and mediates the lysine 63-linked ubiquitination of tumor necrosis factor receptor-associated factor 6 (TRAF6) (Gaffen, 2009; Iwakura et al., 2011). Ubiquitinated TRAF6 then activates the transcriptional factor nuclear factor κB (NFκB), various mitogen-activated protein (MAP) kinases including ERKs and p38, and CCAAT/enhancer-binding proteins (C/EBPβ and C/EBPδ). IL-17A expression and Th17 cell development are remarkably affected not only by microorganisms and tumors, but also by several environmental factors such as nutrients, metabolites, hypoxia, toxins, NaCl concentrations, and circadian rhythm. The tryptophan photoproduct FICZ positively regulates Th17-cell differentiation through AHR, whereas 2,3,7,8-tetrachlorodibezo-p-dioxin (TCDD) negatively regulates differentiation through that receptor (Quintana et al., 2008; Veldhoen et al., 2008). Activation of mTORC1 (mTOR complex containing mLST8 and Raptor) promotes Th17-cell differentiation via positive regulation of hypoxia-inducible factor 1α (HIF1α expression and the activation of S6 kinase (Barbi et al., 2013; Kurebayashi et al., 2013). HIF1α directly upregulates expression of RORγt and IL17A. Therefore, amino acid deprivation selectively blocks Th17-cell development through inhibition of mTORC1, whereas hypoxia promotes Th17 development through the activation of HIF1α. High levels of lactic acid, secreted from tumors due to the Warburg effect, induce macrophages or monocytes to mediate increased IL17A production by Th17 cells in an antigen-dependent manner, but do not Th17-cell differentiation or proliferation (Shime et al., 2008; Yabu et al., 2011). The circadian rhythm is controlled by a series of feedback loops between the transcriptional factors, a CLOCK-BMAL1 complex and REV-ERBα (Arjona et al., 2012). The expression of RORγt is suppressed by the leucine zipper transcriptional factor NFIL3, which is negatively regulated by REV-ERBα (Yu et al., 2013). Accordingly, CD4+ T cells purified during the day express RORγt at higher levels than those purified at night, and tend to differentiate into Th17 cells. High salt concentration (e.g., 40 mM NaCl) induces phosphorylation of p38 and the expression of serum glucocorticoid kinase 1 (SGK1) and nuclear factor of activated T-cells 5 (NFAT5) to promote the IL23-dependent differentiation of pathogenic Th17 cells (Kleinewietfeld et al., 2013; Wu et al., 2013a). In vivo, a high salt diet promotes Th17-cell differentiation and exacerbates neuropathy in mice with experimental autoimmune encephalomyelitis. |
Homology | IL17A is a prototypical member of the IL17 family. This family includes six proteins: IL17A, IL17B, IL17C, IL17D, IL17E (also called IL25), and IL17F. Interleukins 17A-F are not homologous to any other known proteins. IL17A has the highest sequence identity with IL17F (46.5 %). It is less similar to the other IL17 family members: IL17B, 26.4 %; IL17C, 28.9 %; IL17D, 21.8 %; and IL17E, 17.7 %. |
Implicated in |
Note | |
Entity | Ovarian cancer |
Note | Tumor infiltration by Th17 cells is positively correlated with infiltration by Th1 cells, IFNγ-producing CD8+ cells (Tc1 cells), IL17A- and IFNγ-double-positive T cells, and NK cells, but negatively correlated with the presence of Treg cells (Kryczek et al., 2009a). Increased IL17A levels in ascites are well correlated with better patient survival and lower grades of ovarian cancer. |
Entity | Esophageal cancer |
Note | Elevated levels of IL17A-producing cells, including Th17 cells, in esophageal cancer tissues are associated with the intratumoral accumulation of CD8+ T and NK cells, as well as with better prognosis (Lv et al., 2011). |
Entity | Prostate cancer |
Note | In prostate tumors, elevated levels of Th17 cells are associated with a lower pathologic Gleason scores (Sfanos et al., 2008). However, in prostate cancer patients, a higher frequency of CCR4- Th17 cells in peripheral blood is correlated with shorter time to metastatic progression after immunotherapy with an allogeneic whole-cell vaccine (Derhovanessian et al., 2009). |
Entity | Gastric cancer |
Note | The relationship between IL17A and gastric cancer is controversial. Expression of IL17A in peripheral blood mononuclear cells (PBMC) and gastric cancer tissue is elevated, especially in patients with advanced-stage gastric cancer (Zhang et al., 2008; Zhuang et al., 2012; Su et al., 2014). One group suggested that increased infiltration of Tc17 cells in tissues is associated with higher stages and lower overall survival rates (Zhuang et al., 2012). Th17 cells also infiltrate tumors, but the percentage of Th17 cells is lower than that of Tc17 cells. CXCL12, which is produced by tumors stimulated with IL17A, promotes the recruitment of CXCR4-dependent MDSCs and suppresses the function of the cytotoxic CD8+ T cells (Zhuang et al., 2012). However, another group's report showed that intratumoral expression of IL17A is associated with good prognosis (Chen et al., 2011). Several studies have examined the relationship between gastric cancer risk and a single nucleotide polymorphism (SNP) in the IL17A gene promoter region. This SNP (rs2275913, G/A SNP, 52051033 bp from pter) is located at position -197 relative to the start codon within the NFAT-binding motif. The A-allele is associated with higher IL17A promoter activity and higher affinity for NFAT, which plays critical roles in the IL17A production, than the G-allele (Espinoza et al., 2011). Studies of the association between rs2275913 and gastric cancer have yielded different results in different populations. Four groups reported that the AA-genotype and A-allele of SNP rs2275913 are significantly associated with gastric cancer risk in Japanese (Shibata et al., 2009), Iranian (Rafiei et al., 2013), and Chinese populations (Qinghai et al., 2014; Zhang et al., 2014a), whereas one Chinese group reported that this SNP is not associated with total cancer risk or survival in gastric cancer patients (Wu et al., 2010). Two studies suggested that this SNP is significantly associated with gastric cancer risk in Helicobacter pylori-infected patients, smokers, or non-cardia gastric cancer patients (Qinghai et al., 2014; Zhang et al., 2014a). The TT-genotype of the SNP rs3748067, which is localized in 3' UTR of the IL17A gene (C/T SNP, a position at 52055339 bp from pter), was associated with increased risk of gastric cancer in two studies (Qinghai et al., 2014; Zhang et al., 2014a). |
Entity | Colorectal cancer |
Note | Elevated levels of IL17A-producing cells are associated with poor prognosis as a result of increased VEGFA expression in colorectal cancer patients (Liu et al., 2011; Tosolini et al., 2011; Wu et al., 2013b). Furthermore, the A-allele of SNP rs2275913 is positively associated with susceptibility to colorectal cancer, as well as with clinical features as tumor location, tumor differentiation, and TNM stage (Omrane et al., 2014). In a mouse model of colorectal cancer, loss of effective barrier function in the transformed epithelial cells of colonic adenoma results in the infiltration of non-pathogenic bacteria and their products, leading to the production of inflammatory cytokines (including IL23 and IL17A) and the induction of tumor-elicited inflammation, which promotes tumor development (Grivennikov et al., 2012). |
Entity | Hepatocellular cancer |
Note | In patients with hepatocellular carcinoma, increased intratumoral accumulation of IL17A-producing cells is significantly associated with poor prognosis and increased tumor vasculogenesis (Zhang et al., 2009). |
Entity | Uterine cervical cancer |
Note | Levels of Tc17 cells are higher in PBMCs and tumors of uterine cervical cancer patients with lymph-node metastasis than in patients without metastasis (Zhang et al., 2014b). Higher accumulation of Tc17 cells in tumors is associated with a greater degree of tumor vasculogenesis and increased infiltration by Th17 cells and Treg cells. In Chinese women, the AA-genotype and A-allele of IL17A polymorphism rs2275913 are positively associated with susceptibility, peritumoral intravascular cancer emboli, and high clinical stage (Quan et al., 2012). |
Entity | Breast cancer |
Note | Increased infiltration of IL17A-producing cells in tissues is associated with shorter disease-free survival in breast cancer patients and higher histopathological grades (Chen et al., 2013). Among Han Chinese women, the frequency of the AA-genotype of the IL17A SNP rs2275913 is also higher in patients than controls (Wang et al., 2012). IL17A-producing T cells and Treg cells are synchronically increased in peripheral blood and tumor tissues of breast cancer patients relative to those of healthy individuals (Benevides et al., 2013). Levels of the angiogenic factors CXCL8, MMP-2, MMP-9, and VEGFA, which are induced by IL17A, are also elevated in breast cancer tissue. Thus, IL17A is an important prognostic factor in breast cancer. |
Entity | Lung cancer |
Note | Higher levels of IL17A-producing cells are associated with poor prognosis and increased lymphangiogenesis in non-small cell lung cancer tissues (Chen et al., 2010). Although no significant relationship between SNP rs2275913 in the IL17A gene and lung cancer risk has been observed in the total Tunisian population, the A-allele is associated with increased lung cancer risk in the male and smoker subgroups (Kaabachi et al., 2014). |
Entity | Bladder cancer |
Note | The frequency of the AA-genotype and A-allele of SNP rs2275913 in bladder cancer patients is significantly higher than in control Han Chinese populations (Zhou et al., 2013). This SNP is also associated with increased bladder cancer risk in males and non-smokers, as well as with invasion of bladder cancer. |
Entity | Autoimmune and inflammatory diseases |
Note | IL17-producing cells are associated with the pathogenesis of many autoimmune and inflammatory diseases, such as EAE/multiple sclerosis, inflammatory skin diseases/psoriasis, inflammatory bowel diseases, ankylosing spondylitis, and experimental arthritis/rheumatoid arthritis, in both human patients and mouse models (Awasthi and Kuchroo, 2009; Korn et al., 2009). Recent reports have shown that treatment of psoriasis patients with the antibodies that neutralize IL17A and IL17A-IL17F heterodimer or block IL17RA results in reduction in the affected skin area and disease severity (Leonardi et al., 2012; Papp et al., 2012). Thus, therapies targeting the IL17A signaling pathway are predicted to be effective in psoriasis patients. |
Entity | Infections |
Note | Both IL17A and IL17F are preferentially produced during infections with the Gram-negative bacteria Klebsiella pneumoniae in the lungs and Citrobacter rodentium in the colon, the Gram-positive bacterium Staphylococcus aureus in the skin, and the fungus Candida albicans in the mouth; IL17A appears to protect against all of these types of infections (Korn et al., 2009; O'Connor et al., 2010; Iwakura et al., 2011). During the early response to infection, IL17A is predominantly secreted by γδ T cells and iNKT cells, and it induces the production of antimicrobial peptides such as β-defensins, regenerating (REG) proteins, and S100 proteins, as well as granulopoietic factors such as GCSF and CCL20, from epithelial cells (Cua and Tato, 2010). This results in the rapid recruitment of neutrophils to sites of infection, which in turn promotes efficient pathogen clearance. Later, antigen-specific αβ Th17 cells contribute to further responses to infection. |
Entity | Cancers in mouse models |
Note | Elevated expression of IL17A and increased accumulation of IL17A-producing cells in the tumor microenvironment are associated with anti-tumor or pro-tumor effects in various types of cancer in human patients and mouse models (Zou and Restifo, 2010). Although IL17A-producing cells are not the dominant T-cell subset in the tumor microenvironment, their levels are elevated to a greater extent in the tumor site than in peripheral blood of patients (Kryczek et al., 2009a). Recent reports have suggested that the increased accumulation of not only Th17 cells, but also Tc17 (Hinrichs et al., 2009; Zhuang et al., 2012), IL17-producing γδ T cells (Wakita et al., 2010; Schmolka et al., 2013), and ILC3s (Kirchberger et al., 2013), regulates tumor development. Overexpression of IL17A in tumor cells suppresses tumor growth in a cytotoxic T lymphocyte-dependent manner (Benchetrit et al., 2002). The transfer of tumor antigen-specific T cells polarized to the IL17-producing phenotype also induces eradication of tumor cells by inducing strong CD8+ T-cell activation (Martin-Orozco et al., 2009). Furthermore, deficiency of IL17A in mice promotes growth and metastasis of tumors (Kryczek et al., 2009b; Martin-Orozco et al., 2009). IL17A-producing T cells are predicted to induce recruitment of other effector cells (e.g., cytotoxic CD8+ T cells and NK cells) to tumors by inducing expression of CXCL9 and CXCL10 within tumor sites (Kryczek et al., 2009a). Moreover, Th17 cells induce expression of CCL20, a ligand for chemokine (C-C motif) receptor 6 (CCR6), in tumor tissues. CCL20 recruits dendritic cells, which mediate anti-tumor effects in a CCL20/CCR6-dependent manner (Martin-Orozco et al., 2009). On the other hand, overexpression of IL17A in tumors facilitates tumor growth by inducing angiogenesis in the tumor microenvironment (Numasaki et al., 2003; Numasaki et al., 2005). Furthermore, IL17A-deficient or IL17RA-deficient mouse models were used to show that IL17A was involved in the promotion of tumor growth via induction of myeloid-derived suppressor cells (MDSC) (He et al., 2010), activation of IL6-STAT3 pathway (Wang et al., 2009), and elevated angiogenesis (Wakita et al., 2010). The discrepancies between anti-tumor and pro-tumor effects may be due to the distinct roles of IL17A-producing cells in different tumors. A recent report showed that IL17A is involved in tumor resistance to anti-angiogenic therapy targeting vascular endothelial growth factor A (VEGFA) (Chung et al., 2013). In this case, the primary effect of IL17A is the induction of granulocyte colony-stimulating factor (GCSF) expression in tumor-associated fibroblasts, leading to recruitment of MDSC in the tumor microenvironment and induction of another angiogenic factor, prokineticin 2 (PROK2, Bv8). These results suggest that inhibition of IL17A function may improve the efficacy of anti-angiogenic therapies. |
Bibliography |
Immunity's fourth dimension: approaching the circadian-immune connection. |
Arjona A, Silver AC, Walker WE, Fikrig E. |
Trends Immunol. 2012 Dec;33(12):607-12. doi: 10.1016/j.it.2012.08.007. Epub 2012 Sep 20. (REVIEW) |
PMID 23000010 |
Th17 cells: from precursors to players in inflammation and infection. |
Awasthi A, Kuchroo VK. |
Int Immunol. 2009 May;21(5):489-98. doi: 10.1093/intimm/dxp021. Epub 2009 Mar 4. (REVIEW) |
PMID 19261692 |
Metabolic control of the Treg/Th17 axis. |
Barbi J, Pardoll D, Pan F. |
Immunol Rev. 2013 Mar;252(1):52-77. doi: 10.1111/imr.12029. (REVIEW) |
PMID 23405895 |
The Th17 family: flexibility follows function. |
Basu R, Hatton RD, Weaver CT. |
Immunol Rev. 2013 Mar;252(1):89-103. doi: 10.1111/imr.12035. (REVIEW) |
PMID 23405897 |
Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism. |
Benchetrit F, Ciree A, Vives V, Warnier G, Gey A, Sautes-Fridman C, Fossiez F, Haicheur N, Fridman WH, Tartour E. |
Blood. 2002 Mar 15;99(6):2114-21. |
PMID 11877287 |
Enrichment of regulatory T cells in invasive breast tumor correlates with the upregulation of IL-17A expression and invasiveness of the tumor. |
Benevides L, Cardoso CR, Tiezzi DG, Marana HR, Andrade JM, Silva JS. |
Eur J Immunol. 2013 Jun;43(6):1518-28. doi: 10.1002/eji.201242951. Epub 2013 May 16. |
PMID 23529839 |
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors ROR?t and Ahr that leads to IL-17 production by activated B cells. |
Bermejo DA, Jackson SW, Gorosito-Serran M, Acosta-Rodriguez EV, Amezcua-Vesely MC, Sather BD, Singh AK, Khim S, Mucci J, Liggitt D, Campetella O, Oukka M, Gruppi A, Rawlings DJ. |
Nat Immunol. 2013 May;14(5):514-22. doi: 10.1038/ni.2569. Epub 2013 Apr 7. |
PMID 23563688 |
Intratumoral expression of IL-17 and its prognostic role in gastric adenocarcinoma patients. |
Chen JG, Xia JC, Liang XT, Pan K, Wang W, Lv L, Zhao JJ, Wang QJ, Li YQ, Chen SP, He J, Huang LX, Ke ML, Chen YB, Ma HQ, Zeng ZW, Zhou ZW, Chang AE, Li Q. |
Int J Biol Sci. 2011 Jan 11;7(1):53-60. (REVIEW) |
PMID 21234303 |
Interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor. |
Chen WC, Lai YH, Chen HY, Guo HR, Su IJ, Chen HH. |
Histopathology. 2013 Aug;63(2):225-33. doi: 10.1111/his.12156. Epub 2013 Jun 6. |
PMID 23738752 |
Increased IL-17-producing cells correlate with poor survival and lymphangiogenesis in NSCLC patients. |
Chen X, Wan J, Liu J, Xie W, Diao X, Xu J, Zhu B, Chen Z. |
Lung Cancer. 2010 Sep;69(3):348-54. doi: 10.1016/j.lungcan.2009.11.013. |
PMID 20022135 |
An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy. |
Chung AS, Wu X, Zhuang G, Ngu H, Kasman I, Zhang J, Vernes JM, Jiang Z, Meng YG, Peale FV, Ouyang W, Ferrara N. |
Nat Med. 2013 Sep;19(9):1114-23. doi: 10.1038/nm.3291. Epub 2013 Aug 4. |
PMID 23913124 |
Innate IL-17-producing cells: the sentinels of the immune system. |
Cua DJ, Tato CM. |
Nat Rev Immunol. 2010 Jul;10(7):479-89. doi: 10.1038/nri2800. Epub 2010 Jun 18. (REVIEW) |
PMID 20559326 |
Pretreatment frequency of circulating IL-17+ CD4+ T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients. |
Derhovanessian E, Adams V, Hahnel K, Groeger A, Pandha H, Ward S, Pawelec G. |
Int J Cancer. 2009 Sep 15;125(6):1372-9. doi: 10.1002/ijc.24497. |
PMID 19533748 |
Transforming growth factor-beta protein inversely regulates in vivo differentiation of interleukin-17 (IL-17)-producing CD4+ and CD8+ T cells. |
Dwivedi VP, Tousif S, Bhattacharya D, Prasad DV, Van Kaer L, Das J, Das G. |
J Biol Chem. 2012 Jan 27;287(5):2943-7. doi: 10.1074/jbc.C111.327627. Epub 2011 Dec 14. |
PMID 22170065 |
Structural basis of receptor sharing by interleukin 17 cytokines. |
Ely LK, Fischer S, Garcia KC. |
Nat Immunol. 2009 Dec;10(12):1245-51. doi: 10.1038/ni.1813. Epub 2009 Oct 18. |
PMID 19838198 |
A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation. |
Espinoza JL, Takami A, Nakata K, Onizuka M, Kawase T, Akiyama H, Miyamura K, Morishima Y, Fukuda T, Kodera Y, Nakao S; Japan Marrow Donor Program. |
PLoS One. 2011;6(10):e26229. doi: 10.1371/journal.pone.0026229. Epub 2011 Oct 20. |
PMID 22028838 |
IL-17 and IL-22: siblings, not twins. |
Eyerich S, Eyerich K, Cavani A, Schmidt-Weber C. |
Trends Immunol. 2010 Sep;31(9):354-61. doi: 10.1016/j.it.2010.06.004. Epub 2010 Aug 4. (REVIEW) |
PMID 20691634 |
Innate lymphoid cells in homeostasis, infection, chronic inflammation and tumors of the gastrointestinal tract. |
Fuchs A, Colonna M. |
Curr Opin Gastroenterol. 2013 Nov;29(6):581-7. doi: 10.1097/MOG.0b013e328365d339. (REVIEW) |
PMID 24100718 |
Structure and signalling in the IL-17 receptor family. |
Gaffen SL. |
Nat Rev Immunol. 2009 Aug;9(8):556-67. doi: 10.1038/nri2586. Epub 2009 Jul 3. (REVIEW) |
PMID 19575028 |
Structure of IL-17A in complex with a potent, fully human neutralizing antibody. |
Gerhardt S, Abbott WM, Hargreaves D, Pauptit RA, Davies RA, Needham MR, Langham C, Barker W, Aziz A, Snow MJ, Dawson S, Welsh F, Wilkinson T, Vaugan T, Beste G, Bishop S, Popovic B, Rees G, Sleeman M, Tuske SJ, Coales SJ, Hamuro Y, Russell C. |
J Mol Biol. 2009 Dec 18;394(5):905-21. doi: 10.1016/j.jmb.2009.10.008. Epub 2009 Oct 14. |
PMID 19835883 |
Generation of pathogenic T(H)17 cells in the absence of TGF-b signalling. |
Ghoreschi K, Laurence A, Yang XP, Tato CM, McGeachy MJ, Konkel JE, Ramos HL, Wei L, Davidson TS, Bouladoux N, Grainger JR, Chen Q, Kanno Y, Watford WT, Sun HW, Eberl G, Shevach EM, Belkaid Y, Cua DJ, Chen W, O'Shea JJ. |
Nature. 2010 Oct 21;467(7318):967-71. doi: 10.1038/nature09447. |
PMID 20962846 |
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. |
Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M. |
Nature. 2012 Nov 8;491(7423):254-8. doi: 10.1038/nature11465. |
PMID 23034650 |
Cytokine-induced cytokine production by conventional and innate lymphoid cells. |
Guo L, Junttila IS, Paul WE. |
Trends Immunol. 2012 Dec;33(12):598-606. doi: 10.1016/j.it.2012.07.006. Epub 2012 Sep 5. (REVIEW) |
PMID 22959641 |
IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells. |
He D, Li H, Yusuf N, Elmets CA, Li J, Mountz JD, Xu H. |
J Immunol. 2010 Mar 1;184(5):2281-8. doi: 10.4049/jimmunol.0902574. Epub 2010 Jan 29. |
PMID 20118280 |
Type 17 CD8+ T cells display enhanced antitumor immunity. |
Hinrichs CS, Kaiser A, Paulos CM, Cassard L, Sanchez-Perez L, Heemskerk B, Wrzesinski C, Borman ZA, Muranski P, Restifo NP. |
Blood. 2009 Jul 16;114(3):596-9. doi: 10.1182/blood-2009-02-203935. Epub 2009 May 26. |
PMID 19471017 |
Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. |
Hirahara K, Ghoreschi K, Laurence A, Yang XP, Kanno Y, O'Shea JJ. |
Cytokine Growth Factor Rev. 2010 Dec;21(6):425-34. doi: 10.1016/j.cytogfr.2010.10.006. Epub 2010 Nov 16. (REVIEW) |
PMID 21084214 |
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells. |
Hoechst B, Gamrekelashvili J, Manns MP, Greten TF, Korangy F. |
Blood. 2011 Jun 16;117(24):6532-41. doi: 10.1182/blood-2010-11-317321. Epub 2011 Apr 14. |
PMID 21493801 |
A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity. |
Huber M, Heink S, Grothe H, Guralnik A, Reinhard K, Elflein K, Hunig T, Mittrucker HW, Brustle A, Kamradt T, Lohoff M. |
Eur J Immunol. 2009 Jul;39(7):1716-25. doi: 10.1002/eji.200939412. |
PMID 19544308 |
IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. |
Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, Maruoka M, Mao W, Foster J, Kelley RF, Pan G, Gurney AL, de Vos AM, Starovasnik MA. |
EMBO J. 2001 Oct 1;20(19):5332-41. |
PMID 11574464 |
Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. |
Intlekofer AM, Banerjee A, Takemoto N, Gordon SM, Dejong CS, Shin H, Hunter CA, Wherry EJ, Lindsten T, Reiner SL. |
Science. 2008 Jul 18;321(5887):408-11. doi: 10.1126/science.1159806. |
PMID 18635804 |
Functional specialization of interleukin-17 family members. |
Iwakura Y, Ishigame H, Saijo S, Nakae S. |
Immunity. 2011 Feb 25;34(2):149-62. doi: 10.1016/j.immuni.2011.02.012. (REVIEW) |
PMID 21349428 |
Interleukin-17A and -17F genes polymorphisms in lung cancer. |
Kaabachi W, ben Amor A, Kaabachi S, Rafrafi A, Tizaoui K, Hamzaoui K. |
Cytokine. 2014 Mar;66(1):23-9. doi: 10.1016/j.cyto.2013.12.012. Epub 2014 Jan 4. |
PMID 24548421 |
Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. |
Kirchberger S, Royston DJ, Boulard O, Thornton E, Franchini F, Szabady RL, Harrison O, Powrie F. |
J Exp Med. 2013 May 6;210(5):917-31. |
PMID 23589566 |
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. |
Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA. |
Nature. 2013 Apr 25;496(7446):518-22. doi: 10.1038/nature11868. Epub 2013 Mar 6. |
PMID 23467095 |
Interleukin-17 family members and inflammation. |
Kolls JK, Linden A. |
Immunity. 2004 Oct;21(4):467-76. (REVIEW) |
PMID 15485625 |
IL-17 and Th17 Cells. |
Korn T, Bettelli E, Oukka M, Kuchroo VK. |
Annu Rev Immunol. 2009;27:485-517. doi: 10.1146/annurev.immunol.021908.132710. (REVIEW) |
PMID 19132915 |
Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. |
Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S, Huang E, Finlayson E, Simeone D, Welling TH, Chang A, Coukos G, Liu R, Zou W. |
Blood. 2009a Aug 6;114(6):1141-9. doi: 10.1182/blood-2009-03-208249. Epub 2009 May 21. |
PMID 19470694 |
Endogenous IL-17 contributes to reduced tumor growth and metastasis. |
Kryczek I, Wei S, Szeliga W, Vatan L, Zou W. |
Blood. 2009b Jul 9;114(2):357-9. doi: 10.1182/blood-2008-09-177360. Epub 2009 Mar 16. |
PMID 19289853 |
Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells. |
Kurebayashi Y, Nagai S, Ikejiri A, Koyasu S. |
Genes Cells. 2013 Apr;18(4):247-65. doi: 10.1111/gtc.12039. Epub 2013 Feb 5. (REVIEW) |
PMID 23383714 |
Induction and molecular signature of pathogenic TH17 cells. |
Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. |
Nat Immunol. 2012 Oct;13(10):991-9. doi: 10.1038/ni.2416. Epub 2012 Sep 9. |
PMID 22961052 |
Late developmental plasticity in the T helper 17 lineage. |
Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, Elson CO, Weaver CT. |
Immunity. 2009 Jan 16;30(1):92-107. doi: 10.1016/j.immuni.2008.11.005. |
PMID 19119024 |
Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. |
Leonardi C, Matheson R, Zachariae C, Cameron G, Li L, Edson-Heredia E, Braun D, Banerjee S. |
N Engl J Med. 2012 Mar 29;366(13):1190-9. doi: 10.1056/NEJMoa1109997. |
PMID 22455413 |
IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma. |
Liu J, Duan Y, Cheng X, Chen X, Xie W, Long H, Lin Z, Zhu B. |
Biochem Biophys Res Commun. 2011 Apr 8;407(2):348-54. doi: 10.1016/j.bbrc.2011.03.021. Epub 2011 Mar 9. |
PMID 21396350 |
Crystal structures of interleukin 17A and its complex with IL-17 receptor A. |
Liu S, Song X, Chrunyk BA, Shanker S, Hoth LR, Marr ES, Griffor MC. |
Nat Commun. 2013;4:1888. doi: 10.1038/ncomms2880. |
PMID 23695682 |
The accumulation and prognosis value of tumor infiltrating IL-17 producing cells in esophageal squamous cell carcinoma. |
Lv L, Pan K, Li XD, She KL, Zhao JJ, Wang W, Chen JG, Chen YB, Yun JP, Xia JC. |
PLoS One. 2011 Mar 31;6(3):e18219. doi: 10.1371/journal.pone.0018219. |
PMID 21483813 |
T helper 17 cells promote cytotoxic T cell activation in tumor immunity. |
Martin-Orozco N, Muranski P, Chung Y, Yang XO, Yamazaki T, Lu S, Hwu P, Restifo NP, Overwijk WW, Dong C. |
Immunity. 2009 Nov 20;31(5):787-98. doi: 10.1016/j.immuni.2009.09.014. Epub 2009 Oct 29. |
PMID 19879162 |
A structural superfamily of growth factors containing a cystine knot motif. |
McDonald NQ, Hendrickson WA. |
Cell. 1993 May 7;73(3):421-4. (REVIEW) |
PMID 8490958 |
Induced IL-17-producing invariant NKT cells require activation in presence of TGF-b and IL-1b. |
Monteiro M, Almeida CF, Agua-Doce A, Graca L. |
J Immunol. 2013 Jan 15;190(2):805-11. doi: 10.4049/jimmunol.1201010. |
PMID 23293359 |
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. |
Mukasa R, Balasubramani A, Lee YK, Whitley SK, Weaver BT, Shibata Y, Crawford GE, Hatton RD, Weaver CT. |
Immunity. 2010 May 28;32(5):616-27. doi: 10.1016/j.immuni.2010.04.016. Epub 2010 May 13. |
PMID 20471290 |
IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. |
Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H. |
J Immunol. 2005 Nov 1;175(9):6177-89. |
PMID 16237115 |
The dual nature of T(H)17 cells: shifting the focus to function. |
O'Connor W Jr, Zenewicz LA, Flavell RA. |
Nat Immunol. 2010 Jun;11(6):471-6. doi: 10.1038/ni.1882. Epub 2010 May 18. |
PMID 20485275 |
Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. |
Oestreich KJ, Weinmann AS. |
Nat Rev Immunol. 2012 Nov;12(11):799-804. doi: 10.1038/nri3321. Epub 2012 Oct 12. |
PMID 23059426 |
Significant association between interleukin-17A polymorphism and colorectal cancer. |
Omrane I, Marrakchi R, Baroudi O, Mezlini A, Ayari H, Medimegh I, Stambouli N, Kourda N, Bouzaienne H, Uhrhammer N, Bougatef K, Bignon YJ, Benammar-Elgaaied A. |
Tumour Biol. 2014 Apr 4. [Epub ahead of print] |
PMID 24699997 |
Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. |
Papp KA, Leonardi C, Menter A, Ortonne JP, Krueger JG, Kricorian G, Aras G, Li J, Russell CB, Thompson EH, Baumgartner S. |
N Engl J Med. 2012 Mar 29;366(13):1181-9. doi: 10.1056/NEJMoa1109017. |
PMID 22455412 |
Functional development of gammadelta T cells. |
Prinz I, Silva-Santos B, Pennington DJ. |
Eur J Immunol. 2013 Aug;43(8):1988-94. doi: 10.1002/eji.201343759. (REVIEW) |
PMID 23928962 |
Effect of interleukin-17A and interleukin-17F gene polymorphisms on the risk of gastric cancer in a Chinese population. |
Qinghai Z, Yanying W, Yunfang C, Xukui Z, Xiaoqiao Z. |
Gene. 2014 Mar 10;537(2):328-32. doi: 10.1016/j.gene.2013.11.007. Epub 2013 Dec 4. |
PMID 24315816 |
Association between IL17 polymorphisms and risk of cervical cancer in Chinese women. |
Quan Y, Zhou B, Wang Y, Duan R, Wang K, Gao Q, Shi S, Song Y, Zhang L, Xi M. |
Clin Dev Immunol. 2012;2012:258293. doi: 10.1155/2012/258293. Epub 2012 Sep 25. |
PMID 23049595 |
Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. |
Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, Caccamo M, Oukka M, Weiner HL. |
Nature. 2008 May 1;453(7191):65-71. doi: 10.1038/nature06880. Epub 2008 Mar 23. |
PMID 18362915 |
Polymorphism in the interleukin-17A promoter contributes to gastric cancer. |
Rafiei A, Hosseini V, Janbabai G, Ghorbani A, Ajami A, Farzmandfar T, Azizi MD, Gilbreath JJ, Merrell DS. |
World J Gastroenterol. 2013 Sep 14;19(34):5693-9. doi: 10.3748/wjg.v19.i34.5693. |
PMID 24039363 |
CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. |
Rouvier E, Luciani MF, Mattei MG, Denizot F, Golstein P. |
J Immunol. 1993 Jun 15;150(12):5445-56. |
PMID 8390535 |
Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory ?? T cell subsets. |
Schmolka N, Serre K, Grosso AR, Rei M, Pennington DJ, Gomes AQ, Silva-Santos B. |
Nat Immunol. 2013 Oct;14(10):1093-100. doi: 10.1038/ni.2702. Epub 2013 Sep 1. |
PMID 23995235 |
Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. |
Sfanos KS, Bruno TC, Maris CH, Xu L, Thoburn CJ, DeMarzo AM, Meeker AK, Isaacs WB, Drake CG. |
Clin Cancer Res. 2008 Jun 1;14(11):3254-61. doi: 10.1158/1078-0432.CCR-07-5164. |
PMID 18519750 |
Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis. |
Shibata T, Tahara T, Hirata I, Arisawa T. |
Hum Immunol. 2009 Jul;70(7):547-51. doi: 10.1016/j.humimm.2009.04.030. Epub 2009 May 3. |
PMID 19414056 |
Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway. |
Shime H, Yabu M, Akazawa T, Kodama K, Matsumoto M, Seya T, Inoue N. |
J Immunol. 2008 Jun 1;180(11):7175-83. |
PMID 18490716 |
Innate lymphoid cells--a proposal for uniform nomenclature. |
Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, Powrie F, Vivier E. |
Nat Rev Immunol. 2013 Feb;13(2):145-9. doi: 10.1038/nri3365. (REVIEW) |
PMID 23348417 |
Th17 cell expansion in gastric cancer may contribute to cancer development and metastasis. |
Su Z, Sun Y, Zhu H, Liu Y, Lin X, Shen H, Chen J, Xu W, Xu H. |
Immunol Res. 2014 Jan;58(1):118-24. doi: 10.1007/s12026-013-8483-y. |
PMID 24402773 |
Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer. |
Tosolini M, Kirilovsky A, Mlecnik B, Fredriksen T, Mauger S, Bindea G, Berger A, Bruneval P, Fridman WH, Pages F, Galon J. |
Cancer Res. 2011 Feb 15;71(4):1263-71. doi: 10.1158/0008-5472.CAN-10-2907. Epub 2011 Feb 8. |
PMID 21303976 |
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. |
Veldhoen M, Hirota K, Westendorf AM, Buer J, Dumoutier L, Renauld JC, Stockinger B. |
Nature. 2008 May 1;453(7191):106-9. doi: 10.1038/nature06881. Epub 2008 Mar 23. |
PMID 18362914 |
Tumor-infiltrating IL-17-producing gammadelta T cells support the progression of tumor by promoting angiogenesis. |
Wakita D, Sumida K, Iwakura Y, Nishikawa H, Ohkuri T, Chamoto K, Kitamura H, Nishimura T. |
Eur J Immunol. 2010 Jul;40(7):1927-37. doi: 10.1002/eji.200940157. |
PMID 20397212 |
Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer. |
Wang L, Jiang Y, Zhang Y, Wang Y, Huang S, Wang Z, Tian B, Yang Y, Jiang W, Pang D. |
PLoS One. 2012;7(3):e34400. doi: 10.1371/journal.pone.0034400. Epub 2012 Mar 26. |
PMID 22461912 |
IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. |
Wang L, Yi T, Kortylewski M, Pardoll DM, Zeng D, Yu H. |
J Exp Med. 2009 Jul 6;206(7):1457-64. doi: 10.1084/jem.20090207. Epub 2009 Jun 29. |
PMID 19564351 |
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. |
Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo VK. |
Nature. 2013a Apr 25;496(7446):513-7. doi: 10.1038/nature11984. Epub 2013 Mar 6. |
PMID 23467085 |
Interleukin-17: a promoter in colorectal cancer progression. |
Wu D, Wu P, Huang Q, Liu Y, Ye J, Huang J. |
Clin Dev Immunol. 2013b;2013:436307. doi: 10.1155/2013/436307. Epub 2013 Dec 7. (REVIEW) |
PMID 24382972 |
Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer. |
Wu X, Zeng Z, Chen B, Yu J, Xue L, Hao Y, Chen M, Sung JJ, Hu P. |
Int J Cancer. 2010 Jul 1;127(1):86-92. doi: 10.1002/ijc.25027. |
PMID 19904747 |
IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid. |
Yabu M, Shime H, Hara H, Saito T, Matsumoto M, Seya T, Akazawa T, Inoue N. |
Int Immunol. 2011 Jan;23(1):29-41. doi: 10.1093/intimm/dxq455. Epub 2010 Dec 3. |
PMID 21131367 |
TH17 cell differentiation is regulated by the circadian clock. |
Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV. |
Science. 2013 Nov 8;342(6159):727-30. doi: 10.1126/science.1243884. |
PMID 24202171 |
The prevalence of Th17 cells in patients with gastric cancer. |
Zhang B, Rong G, Wei H, Zhang M, Bi J, Ma L, Xue X, Wei G, Liu X, Fang G. |
Biochem Biophys Res Commun. 2008 Sep 26;374(3):533-7. doi: 10.1016/j.bbrc.2008.07.060. Epub 2008 Jul 23. |
PMID 18655770 |
Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. |
Zhang JP, Yan J, Xu J, Pang XH, Chen MS, Li L, Wu C, Li SP, Zheng L. |
J Hepatol. 2009 May;50(5):980-9. doi: 10.1016/j.jhep.2008.12.033. Epub 2009 Mar 11. |
PMID 19329213 |
Analysis of the association of interleukin-17 gene polymorphisms with gastric cancer risk and interaction with Helicobacter pylori infection in a Chinese population. |
Zhang X, Zheng L, Sun Y, Zhang X. |
Tumour Biol. 2014a Feb;35(2):1575-80. doi: 10.1007/s13277-013-1217-x. Epub 2013 Nov 12. |
PMID 24218334 |
Tc17 cells in patients with uterine cervical cancer. |
Zhang Y, Hou F, Liu X, Ma D, Zhang Y, Kong B, Cui B. |
PLoS One. 2014b Feb 11;9(2):e86812. doi: 10.1371/journal.pone.0086812. eCollection 2014. |
PMID 24523865 |
Interleukin-17 gene polymorphisms are associated with bladder cancer in a Chinese Han population. |
Zhou B, Zhang P, Wang Y, Shi S, Zhang K, Liao H, Zhang L. |
Mol Carcinog. 2013 Nov;52(11):871-8. doi: 10.1002/mc.21928. Epub 2012 Jun 12. |
PMID 22692973 |
CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer. |
Zhuang Y, Peng LS, Zhao YL, Shi Y, Mao XH, Chen W, Pang KC, Liu XF, Liu T, Zhang JY, Zeng H, Liu KY, Guo G, Tong WD, Shi Y, Tang B, Li N, Yu S, Luo P, Zhang WJ, Lu DS, Yu PW, Zou QM. |
Gastroenterology. 2012 Oct;143(4):951-62.e8. doi: 10.1053/j.gastro.2012.06.010. Epub 2012 Jun 15. |
PMID 22710190 |
T(H)17 cells in tumour immunity and immunotherapy. |
Zou W, Restifo NP. |
Nat Rev Immunol. 2010 Apr;10(4):248-56. doi: 10.1038/nri2742. (REVIEW) |
PMID 20336152 |
Citation |
This paper should be referenced as such : |
N Inoue, T Akazawa |
IL17A (interleukin 17A) |
Atlas Genet Cytogenet Oncol Haematol. 2015;19(1):18-27. |
Free journal version : [ pdf ] [ DOI ] |
History of this paper: |
Inoue, N ; Akazawa, T. IL17A (interleukin 17A). Atlas Genet Cytogenet Oncol Haematol. 2011;15(8):662-666. |
http://documents.irevues.inist.fr/bitstream/handle/2042/46016/01-2011-IL17AID40945ch6p12.pdf |
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